Prednisolone
| Prednisolone | |
|---|---|
 | |
| Molecular structure via molpic based on CDK |
| Rotamer [] | |
|---|---|
| Conformer structure via 3Dmol.js |
| Physical properties [] | |
|---|---|
| Molecular mass | 360.4 g/mol [1] |
| Appearance | Crystals [1] |
| Odor | Odorless [1] |
| Melting point | 235 °C [1] |
| Solubility | SPECIFIC OPTICAL ROTATION: +102.5 DEG @ 25 °C/D; PH OF 1% SOLN 7.5 TO 8.5; SOL IN WATER, METHANOL, ETHANOL. /PHOSPHATE SODIUM/ [1] |
| Predicted LogP | 1.6 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C21H28O5 [1] |
| IUPAC name | (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one [1] |
| SMILES | C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O [1] |
| InChI | InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 [1] |
| InChIKey | OIGNJSKKLXVSLS-VWUMJDOOSA-N [1] |
| Pharmacokinetics[] | |
|---|---|
| Elimination half-life | 2 – 3.5 hours[3][4][5] |
Prednisolone (also known as Prednisolone, Metacortandralone, Hydroretrocortine, Δcortril, Δ-Cortef, Codelcortone, Prenolone, Sterane, Δhydrocortisone or Cortalone) is a
Chemistry
Stereochemistry []
Prednisolone is a absolute mixture.
Pharmacology
ATC Classification
In the sensory organs (S) prednisolone acts In the cardiovascular system (C) prednisolone acts In the alimentary tract and metabolism (A) prednisolone acts In the systemic hormonal preparations, excl. sex hormones and insulins (H) prednisolone acts In the dermatologicals (D) prednisolone acts In the respiratory system (R) prednisolone acts In the sensory organs (S) prednisolone acts In the sensory organs (S) prednisolone acts In the alimentary tract and metabolism (A) prednisolone acts In the sensory organs (S) prednisolone acts In the dermatologicals (D) prednisolone actsMetabolism
Interactions
| CYP3A | induction / inhibition |
|---|
Subjective effects []
| emily / Prednisolone [] | |
|---|---|
Routes:
| |
Legal status []
- United Kingdom: Prednisolone is a prescription only substance.
- United States: Prednisolone is a prescription only substance.
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 5755, Prednisolone. Accessed April 24, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/5755
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Prednisolone. UNII: 9PHQ9Y1OLM. Global Substance Registration System. Accessed April 24, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/9PHQ9Y1OLM
Pickup ME. Clinical pharmacokinetics of prednisone and prednisolone. Clinical Pharmacokinetics. 1979; 4(2):111–128.
Bergrem H, Grøttum P, Rugstad HE. Pharmacokinetics and protein binding of prednisolone after oral and intravenous administration. European Journal of Clinical Pharmacology. 1983; 24(3):415–419.
Bashar T, Apu MN, Mostaid MS, Islam MS, Hasnat A. Pharmacokinetics and Bioavailability Study of a Prednisolone Tablet as a Single Oral Dose in Bangladeshi Healthy Volunteers. Dose-Response. 2018; 16(3)