N-Methylbupropion

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	253.77 g/mol ^[1]
Predicted LogP	3.7 ^[1]

Structural Identifiers []
Molecular formula	C₁₄H₂₀ClNO ^[1]
IUPAC name	2-[tert-butyl(methyl)amino]-1-(3-chlorophenyl)propan-1-one ^[1]
SMILES	CC(C(=O)C1=CC(=CC=C1)Cl)N(C)C(C)(C)C ^[1]
InChI	InChI=1S/C14H20ClNO/c1-10(16(5)14(2,3)4)13(17)11-7-6-8-12(15)9-11/h6-10H,1-5H3 ^[1]
InChIKey	BJLKZFUZNNATGZ-UHFFFAOYSA-N ^[1]

N-Methylbupropion

N-Methylbupropion (also known as N-Methylbupropion, N-methyl-bupropion, 2-(tert-butyl(methyl)amino)-1-(3-chlorophenyl)propan-1-one or 2-(N-Methyl-N-tert-butylamino)-3''-chloropropiophenone) is a stimulant substance of the amphetamine class.

Chemistry

Stereochemistry []

N-Methylbupropion is a racemic mixture of the enantiomers

Stereoisomers
(R)-N-Methylbupropion (S)-N-Methylbupropion

Pharmacology

N-Methylbupropion acts as a prodrug for:

Active metabolites []
Bupropion Hydroxybupropion Threohydrobupropion Erythrohydrobupropion

Subjective effects []

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 20695745, N-Methylbupropion. Accessed August 31, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/20695745

Anodyne