Anodyne

IC-26, WIN 1161-3

Salts []
Methiodone hydrochloride

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	345.5 g/mol ^[1]
Predicted LogP	3.8 ^[1]

Structural Identifiers []
Molecular formula	C₂₀H₂₇NO₂S ^[1]
IUPAC name	4-ethylsulfonyl-N,N-dimethyl-4,4-diphenylbutan-2-amine ^[1]
SMILES	CCS(=O)(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2 ^[1]
InChI	InChI=1S/C20H27NO2S/c1-5-24(22,23)20(16-17(2)21(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3 ^[1]
InChIKey	NLPGJSPLDNDKKZ-UHFFFAOYSA-N ^[1]

Methiodone

Methiodone (also known as IC-26, Propylamine, 3-(ethylsulfonyl)-N,N,1-trimethyl-3,3-diphenyl-, γ-(Ethylsulfonyl)-N,N,α-trimethyl-γ-phenylbenzenepropanamine, Benzenepropanamine, γ-(ethylsulfonyl)-N,N,α-trimethyl-γ-phenyl-, γ-(Ethylsulfonyl)-n,n,α-trimethyl-γ-phenylbenzenepropanamine, Benzenepropanamine, γ-(ethylsulfonyl)-n,n,α-trimethyl-γ-phenyl-, RefChem:147585, WIN 1161-3 or 4-(ethanesulfonyl)-N,N-dimethyl-4,4-diphenylbutan-2-amine) is a opioid substance of the phenylpropylamine class.

Chemistry

Salts []

Methiodone is typically found in the form of its hydrochloride salt.

Stereochemistry []

Methiodone is a racemic mixture of the enantiomers

Stereoisomers
(S)-Methiodone (R)-Methiodone

Subjective effects []

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

Anodyne Usernotes []
magnus / Methiodone	-

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 113832, Methiodone. Accessed September 1, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/113832
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Methiodone. UNII: ZSY3T8J4AQ. Global Substance Registration System. Accessed September 1, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/ZSY3T8J4AQ