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Fexofenadine

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Fexofenadine
Fexofenadine
Salts
[]
Fexofenadine hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
[]
501.7 g/mol [1]
AppearanceCrystals from methanol-butanone [1]
Melting point195-197 °C [1]
SolubilitySlightly soluble [1]
3 [1]
Structural Identifiers
[]
C32H39NO4 [1]
2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid [1]
CC(C)(C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O)C(=O)O [1]
InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36) [1]
InChIKeyRWTNPBWLLIMQHL-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life14.4 hours

Fexofenadine (also known as Fexofenadine, 83799-24-0, Carboxyterfenadine, Terfenadine carboxylate, Terfenadine-COOH, Terfenadine acid metabolite, Telfast, MDL 16455, Fexofenadina or 2-(4-{1-Hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid) is a substance of the carboxylic acid class.

Chemistry

Salts []

Fexofenadine is typically found in the form of its hydrochloride salt.

 []

Fexofenadine is a racemic mixture of the .

Pharmacology

In the () fexofenadine acts

Metabolism

Subjective effects []

0xea / Fexofenadine []
  • Routes:
    • Oral (120mg)
  • Salts:
    • Hydrochloride

Legal status []

  • Australia: Fexofenadine is a S2 substance.
  • Brazil: Fexofenadine is a OTC substance.
  • Canada: Fexofenadine is a OTC substance.
  • United Kingdom: Fexofenadine is a P substance.[3][4][5]
  • United States: Fexofenadine is a OTC substance.

See also []

  • Substituted carboxylic acids
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 3348, Fexofenadine. Accessed March 10, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3348

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Fexofenadine. UNII: E6582LOH6V. Global Substance Registration System. Accessed March 10, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/E6582LOH6V

    3. Telfast 30mg Film-coated Tablets - Summary of Product Characteristics (SmPC). October 25, 2019. Accessed March 10, 2026. https://www.medicines.org.uk/emc/product/5529/smpc

    4. Almerg 180 mg Film-Coated Tablets - Summary of Product Characteristics (SmPC). Accessed March 10, 2026. https://www.medicines.org.uk/emc/product/10147/smpc

    5. Fexofenadine Hydrochloride 120 mg Film-Coated Tablets - Summary of Product Characteristics (SmPC). March 22, 2021. Accessed March 10, 2026. https://www.medicines.org.uk/emc/product/10144/smpc