Clephedrone

4-CMC

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	197.66 g/mol ^[1]
Predicted LogP	2.2 ^[1]

Structural Identifiers []
Molecular formula	C₁₀H₁₂ClNO ^[1]
IUPAC name	1-(4-chlorophenyl)-2-(methylamino)propan-1-one ^[1]
SMILES	CC(C(=O)C1=CC=C(C=C1)Cl)NC ^[1]
InChI	InChI=1S/C10H12ClNO/c1-7(12-2)10(13)8-3-5-9(11)6-4-8/h3-7,12H,1-2H3 ^[1]
InChIKey	UEJBEYOXRNGPEI-UHFFFAOYSA-N ^[1]

Clephedrone (also known as Clephedrone, 4-cmc, 4-Chloromethcathinone, Dtxsid201014163, Dtxcid501436704, Unii-ptayyyzmmt, 1-(4-Chlorophenyl)-2-(methylamino)propan-1-one, para-Chloro-N-methyl-cathinone, 4-Chloromethcathinone hydrochloride or Chloromethcathinone) is a stimulant substance of the cathinone class.

Chemistry

Stereochemistry []

Clephedrone is a racemic mixture of the enantiomers.

Stereoisomerism
(R)-Clephedrone (S)-Clephedrone
Stereoisomer enumberation with rdkit

Subjective effects []

class / Stimulant

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Legal status []

Brazil: Clephedrone is a F2 substance.
Germany: Clephedrone is a Anlage I substance.
United Kingdom: Clephedrone is a Class B substance.
United Nations: Clephedrone is a Schedule II drug under the "Convention on Psychotropic Substances 1971".

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 82100418, Clephedrone. Accessed May 4, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/82100418
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Clephedrone. UNII: PTAYYYZMMT. Global Substance Registration System. Accessed May 4, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/PTAYYYZMMT

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