Hydroxyzine

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	374.9 g/mol ^[1]
Appearance	Oil ^[1]
Melting point	200C ^[1]
Boiling point	220 °C ^[1]
Solubility	Crystals; MP 193 °C; Bitter taste. Solubility in mg/mL: water <700; chloroform 60; acetone 2; ether <0.1. Solutions are unstable to intense UV light. /Hydroxyzine dihydrochloride/ ^[1]
Predicted LogP	3.7 ^[1]

Structural Identifiers []
Molecular formula	C₂₁H₂₇ClN₂O₂ ^[1]
IUPAC name	2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol ^[1]
SMILES	C1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl ^[1]
InChI	InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 ^[1]
InChIKey	ZQDWXGKKHFNSQK-UHFFFAOYSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	Adults: 20.0 hoursElderly: 29.3 hoursChildren: 7.1 hours

Hydroxyzine

Hydroxyzine (also known as Hydroxyzine, 68-88-2, Hydroxizine, Hydroxyzin, Hydroxine, Hydroxycine, Tranquizine, Ataraxoid, Hychotine or Tran-Q) is a substance of the α-alkylbenzylamine class.

Chemistry

Stereochemistry []

Hydroxyzine is a racemic mixture of the enantiomers

Legal status []

Australia: Hydroxyzine is a S4 substance.
Canada: Hydroxyzine is a prescription only substance.
European Union: Hydroxyzine is a prescription only substance.
United Kingdom: Hydroxyzine is a prescription only substance.
United States: Hydroxyzine is a prescription only substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 3658, Hydroxyzine. Accessed January 5, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/3658
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Hydroxyzine. UNII: 30S50YM8OG. Global Substance Registration System. Accessed January 5, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/30S50YM8OG

Anodyne