Dienogest

DNG

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	311.4 g/mol ^[1]
Melting point	210-218 ^[1]
Solubility	Practically insoluble ^[1]
Predicted LogP	1.8 ^[1]

Structural Identifiers []
Molecular formula	C₂₀H₂₅NO₂ ^[1]
IUPAC name	2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile ^[1]
SMILES	C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC#N)O ^[1]
InChI	InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1 ^[1]
InChIKey	AZFLJNIPTRTECV-FUMNGEBKSA-N ^[1]

Dienogest (also known as Dienogestril, Dienogestum, Endometrion, STS 557, STS-557, MJR-35, 17α-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile, ZK 37659, M 18575 or M-18575)

Chemistry

Stereochemistry []

Dienogest is a achiral mixture.

Druglikeness

Lipinski's rule of five

Dienogest matches Lipinski's rule of five.

Pharmacology

ATC Classification

emily / Dienogest []
Routes: Oral (2mg)

Pilz / Dienogest []
Routes: Oral (2mg) Indication: Male to female Transsexual Notes: Might be useful as an Antiandrogen

Pilz / Dienogest []

Routes:

Oral (2mg)

Indication:

Male to female Transsexual

Notes:

Might be useful as an Antiandrogen

Legal status []

Australia: Dienogest is a S4 substance.

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 68861, Dienogest. Accessed June 24, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/68861

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