Codeine-6-glucuronide

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	475.5 g/mol ^[1]
Melting point	248-250 °C ^[1]
Solubility	High ^[1]
Predicted LogP	-2.5 ^[1]

Structural Identifiers []
Molecular formula	C₂₄H₂₉NO₉ ^[1]
IUPAC name	(2S,3S,4S,5R,6R)-6-[[(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid ^[1]
SMILES	CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)OC)O[C@H]3[C@H](C=C4)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(=O)O)O)O)O ^[1]
InChI	InChI=1S/C24H29NO9/c1-25-8-7-24-11-4-6-14(32-23-18(28)16(26)17(27)20(34-23)22(29)30)21(24)33-19-13(31-2)5-3-10(15(19)24)9-12(11)25/h3-6,11-12,14,16-18,20-21,23,26-28H,7-9H2,1-2H3,(H,29,30)/t11-,12+,14-,16-,17-,18+,20-,21-,23+,24-/m0/s1 ^[1]
InChIKey	CRWVOYRJXPDBPM-HSCJLHHPSA-N ^[1]

Codeine-6-glucuronide

Codeine-6-glucuronide (also known as β-D-Glucopyranosiduronic acid, (5α,6α)-7,8-didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-yl, C16577, codeine glucuronide, Codeine-6G, Codeine 6-β-D-Glucuronide, Codeine-6-glucuronide sodium salt, C-6-g hydrate-trifluoroacetate, Codeine-6-ss-D-glucuronide-D3 solution, Glucopyranosiduronic acid, codeine, b-D- or Codeine 6-β-D-Glucuronide 0.1 mg/ml in Water) is a opioid substance of the morphinan class.

Chemistry

Stereochemistry []

Codeine-6-glucuronide is a absolute mixture

Subjective effects []

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 5489029, Codeine-6-glucuronide. Accessed July 19, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/5489029
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Codeine-6-glucuronide. UNII: E2M937KY47. Global Substance Registration System. Accessed July 19, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/E2M937KY47

Anodyne