Anodyne

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4-FMPH
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
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251.30 g/mol [1]
0.3 [1]
Structural Identifiers
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C14H18FNO2 [1]
methyl (2R)-2-(4-fluorophenyl)-2-[(2R)-piperidin-2-yl]acetate [1]
COC(=O)[C@@H]([C@H]1CCCCN1)C2=CC=C(C=C2)F [1]
InChI=1S/C14H18FNO2/c1-18-14(17)13(12-4-2-3-9-16-12)10-5-7-11(15)8-6-10/h5-8,12-13,16H,2-4,9H2,1H3/t12-,13-/m1/s1 [1]
InChIKeyXISBAJBPDVRSPG-CHWSQXEVSA-N [1]

4-Fluoromethylphenidate

4-Fluoromethylphenidate (also known as 4F-Mph, 4-Fmph, 2-Piperidineacetic acid, α-(4-fluorophenyl)-, methyl ester, (αR,2R)-rel-, RefChem:99032, methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate, Methyl (2R)-(4-fluorophenyl)[(2R)-piperidin-2-yl]acetate, methyl 2-(4-fluorophenyl)-2-((R)-piperidin-2-yl)acetate, 2-Piperidineacetic acid, α-(4-fluorophenyl)-, methyl ester or 2-Piperidineacetic acid, α-(4-fluorophenyl)-, methyl ester, (αr,2r)-rel-) is a substance of the phenidate class.

Chemistry

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4-Fluoromethylphenidate is a achiral mixture of the optical stereoisomers

Anodyne Usernotes
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magnus / 4-Fluoromethylphenidate[hydrochloride] via Oral and Insufflatedmethylphenidate's big brother; very similar pharmacological effects longer duration, higher potency more recreational; batches from spring 2023 were clean white crystals; later batches 2024 changed the source/synthesis route changing the distribution of stereoisomers resulting in an off-white clumpy texture and drastically reduced potency

See also []

  • Substituted phenidates
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 52944002, 4-Fluoromethylphenidate. Accessed September 1, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/52944002

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 4-Fluoromethylphenidate. UNII: TN2LV2C0X9. Global Substance Registration System. Accessed September 1, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/TN2LV2C0X9