Anodyne

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Sertraline
Generated by the Chemistry Development Kit (http://github.com/cdk)
Salts
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Sertraline hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
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306.2 g/mol [1]
Melting point245-246 [1]
Boiling point416.3±45.0 °C [1]
Solubility>45.9 [ug/mL] (The mean of the results at pH 7.4) [1]
4.8 [1]
Structural Identifiers
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C17H17Cl2N [1]
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine [1]
CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl [1]
InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 [1]
InChIKeyVGKDLMBJGBXTGI-SJCJKPOMSA-N [1]
Toxicity
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Human - female:
- oral: 2 mg/kg/2D-I
- oral: 63 mg/kg/10W-I
- oral: 70 mg/kg/7W-I
- oral: 28 mg/kg/4W-I
- oral: 10500 μg/kg/3W
- oral: 6 mg/kg/4D-I
Human - male:
- oral: 5714 μg/kg/9D-
- oral: 3571 mg/kg/5D-

Sertraline

Sertraline (also known as Sertralina, Sertralinum, Cp 51974, cis-(+)-sertraline, (1S,4S)-sertraline, (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine, Altruline, 1-Naphthalenamine, 1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-, Besitran or Apo Sertraline) is a serotonin reuptake inhibitor substance of the α-alkylbenzylamine class.

Chemistry

Salts []

Sertraline is typically found in the form of its hydrochloride salt.

 []

Sertraline is a absolute mixture

Anodyne Usernotes
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0xea / Sertraline via Oralseams to improve well being after MDMA use; notable potenciation of Dextroamphetamine (Lisdexamphetamine) through CYP2D6 inhibition

See also []

  • Substituted α-alkylbenzylamines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 68617, Sertraline. Accessed August 16, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/68617

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Sertraline. UNII: QUC7NX6WMB. Global Substance Registration System. Accessed August 16, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/QUC7NX6WMB