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Sertraline

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Sertraline
Sertraline
[]
Sertraline hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
[]
Conformer structure via 3Dmol.js
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Physical properties
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306.2 g/mol [1]
Melting point245-246 [1]
Boiling point416.3±45.0 °C [1]
Solubility3.8mg/mL [1]
4.8 [1]
Structural Identifiers
[]
C17H17Cl2N [1]
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine [1]
CN[C@H]1CC[C@H](C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl [1]
InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1 [1]
InChIKeyVGKDLMBJGBXTGI-SJCJKPOMSA-N [1]
Pharmacokinetics[]
Elimination half-life• Sertraline: 26 hours (32 hours in females, 22 hours in males; range 13 – 45 hours)[4]• Desmethylsertraline: 62 – 104 hours

Sertraline (also known as Sertraline, Sertralina, Sertralinum, cis-(+)-sertraline, Cp 51974, (1S,4S)-sertraline, (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine, CHEBI:9123, Dtxsid6023577 or 1-Naphthalenamine, 1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-) is a serotonin reuptake inhibitor substance of the α-alkylbenzylamine class.

Chemistry

Salts []

Sertraline is typically found in the form of its hydrochloride salt.

 []

Sertraline is a absolute mixture.

Pharmacology

In the () sertraline acts as a antidepressant (), psychoanaleptic (), selective serotonin reuptake inhibitor () and sertraline ().[1]

Interactions []

induction / inhibition
induction / inhibition
induction / inhibition
induction / inhibition

Subjective effects []

0xea / Sertraline []
Routes:
  • Oral (25mg)
Salts:
  • Hydrochloride
Indication:Effects:
  • seams to improve well being after MDMA use
  • notable potenciation of dextroamphetamine through CYP2D6 inhibition

 []

  • Australia: Sertraline is a S4 substance.
  • Brazil: Sertraline is a C1 substance.[3]
  • Canada: Sertraline is a prescription only substance.
  • New Zealand: Sertraline is a Prescription only substance.
  • United Kingdom: Sertraline is a prescription only substance.
  • United States: Sertraline is a prescription only substance.

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 68617, Sertraline. Accessed April 16, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/68617

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Sertraline. UNII: QUC7NX6WMB. Global Substance Registration System. Accessed April 16, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/QUC7NX6WMB

  3. Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed April 16, 2026. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992

  4. Brunton L, Chabner B, Knollman B. Goodman and Gilman's The Pharmacological Basis of Therapeutics. McGraw Hill Professional. 2010.