3,4-Methylenedioxymephenidine

UWA-001

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	255.31 g/mol ^[1]
Predicted LogP	3.2 ^[1]

Structural Identifiers []
Molecular formula	C₁₆H₁₇NO₂ ^[1]
IUPAC name	2-(1,3-benzodioxol-5-yl)-N-methyl-1-phenylethanamine ^[1]
SMILES	CNC(CC1=CC2=C(C=C1)OCO2)C3=CC=CC=C3 ^[1]
InChI	InChI=1S/C16H17NO2/c1-17-14(13-5-3-2-4-6-13)9-12-7-8-15-16(10-12)19-11-18-15/h2-8,10,14,17H,9,11H2,1H3 ^[1]
InChIKey	DNOTUUOUOFJQJC-UHFFFAOYSA-N ^[1]

3,4-Methylenedioxymephenidine (also known as α-Phenyl-mdma, UWA-001, Unii-zq2r4kpz2w, N-Methyl-α-phenyl-1,3-benzodioxole-5-ethanamine, 1,3-Benzodioxole-5-ethanamine, N-methyl-α-phenyl-, Chembl3303514, Schembl25224327, Dtxsid301045824, N-methyl-α-phenyl-1,3-benzodioxole-5-ethanamine or 1,3-Benzodioxole-5-ethanamine, n-methyl-α-phenyl-) is a entactogen and cytotoxin substance of the 3,4-methylenedioxyphenethylamine and 1,2-diarylethylamine class.

Chemistry

Stereochemistry []

3,4-Methylenedioxymephenidine is a racemic mixture of the enantiomers.

Stereoisomerism
(R)-3,4-Methylenedioxymephenidine (S)-3,4-Methylenedioxymephenidine
Stereoisomer enumberation with rdkit

Subjective effects []

class / Entactogen Cytotoxin

Physical effects
Increased libido Restless legs Shakiness Teeth grinding

Cognitive effects
Cognitive euphoria Disinhibition Empathy, effection, and sociability enhancement Increased music appreciation

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 17757315, Methylenedioxymephenidine. Accessed May 6, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/17757315
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. 3,4-Methylenedioxymephenidine. UNII: ZQ2R4KPZ2W. Global Substance Registration System. Accessed May 6, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/ZQ2R4KPZ2W

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