AnodyneWiki

Enable 3Dmol.js
Collapse all
Light theme

α-Pyrrolidinopentiophenone

Read
α-PVP, O-2387
α-Pyrrolidinopentiophenone
Salts
[]
α-Pyrrolidinopentiophenone hydrochloride
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
[]
231.33 g/mol [1]
3.4 [1]
Structural Identifiers
[]
C15H21NO [1]
1-phenyl-2-pyrrolidin-1-ylpentan-1-one [1]
CCCC(C(=O)C1=CC=CC=C1)N2CCCC2 [1]
InChI=1S/C15H21NO/c1-2-8-14(16-11-6-7-12-16)15(17)13-9-4-3-5-10-13/h3-5,9-10,14H,2,6-8,11-12H2,1H3 [1]
InChIKeyYDIIDRWHPFMLGR-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life~2.1 hourshttps://pmc.ncbi.nlm.nih.gov/articles/PMC8604100/#:~:text=elimination%20half%2Dlife%20(t1/2)%20of%20approximately%202.1%20h
Duration of action3 – 5 hours

α-Pyrrolidinopentiophenone (also known as α-pyrrolidinovalerophenone, Desmethyl pyrovalerone, O-2387, J3.169.878b, Dtxcid001003637, α-PVP, Flakka, 1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one, Gravel or Prolintanone) is a stimulant substance of the pyrrolidinophenone class.

Chemistry

Salts []

α-Pyrrolidinopentiophenone is typically found in the form of its hydrochloride salt.

 []

α-Pyrrolidinopentiophenone is a racemic mixture of the .

(R)-α-PyrrolidinopentiophenoneGenerated by the Chemistry Development Kit (http://github.com/cdk)
(S)-α-PyrrolidinopentiophenoneGenerated by the Chemistry Development Kit (http://github.com/cdk)
Stereoisomer enumberation with rdkit

α-Pyrrolidinopentiophenone matches Lipinski's rule of five.

There are currently 13 reagent-interactions on

ReagentColor change
Marquis
Mecke
Mandelin
Liebermann
Froehde
Simon's
Ehrlich
Hofmann
Scott
Morris
Zimmermann
Gallic
Folin

Subjective effects []

class / Stimulant
bonzi / α-Pyrrolidinopentiophenone []
Routes:
  • Vaporized
  • Insufflated
  • Oral
Effects:
x86pup / α-Pyrrolidinopentiophenone []
Routes:
  • Insufflated
0xea / α-Pyrrolidinopentiophenone []
Routes:
  • Intravenous (5 - 60mg)
    Onset: 10 s
    Duration: 3 - 4 h
  • Vaporized (15mg)
  • Intrarectal (10mg)
Salts:
  • Hydrochloride
Effects:
  • Intravenous 25mg
  • Intravenous >50mg
    • when dosed too frequently multi-hour peroids of strong dissociation

 []

  • Australia: α-Pyrrolidinopentiophenone is a S9 substance.
  • Brazil: α-Pyrrolidinopentiophenone is a F2 substance.[3]
  • Canada: α-Pyrrolidinopentiophenone is a Unscheduled substance.
  • United Kingdom: α-Pyrrolidinopentiophenone is a Class B substance.
  • United States: α-Pyrrolidinopentiophenone is a Schedule I under the "Controlled Substances Act (CSA)".
  • Germany: α-Pyrrolidinopentiophenone is a Anlage II substance.
  • New Zealand: α-Pyrrolidinopentiophenone is a Class C substance.
  • United Nations: α-Pyrrolidinopentiophenone is a Schedule II drug under the "Convention on Psychotropic Substances 1971".

See also []

External links []

References []

  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 11148955, α-Pyrrolidinopentiophenone. Accessed June 9, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/11148955

  2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. α-Pyrrolidinopentiophenone. UNII: 767K3AWA4R. Global Substance Registration System. Accessed June 9, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/767K3AWA4R

  3. Anvisa. RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. July 24, 2023. Accessed June 9, 2026. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-804-de-24-de-julho-de-2023-498447451