Anodyne

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Sumatriptan
Generated by the Chemistry Development Kit (http://github.com/cdk)
Salts
[]
Sumatriptan succinate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
[]
295.40 g/mol [1]
Melting point169-170 [1]
Solubility40.3 [ug/mL] (The mean of the results at pH 7.4) [1]
0.9 [1]
Structural Identifiers
[]
C14H21N3O2S [1]
1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-methylmethanesulfonamide [1]
CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C [1]
InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3 [1]
InChIKeyKQKPFRSPSRPDEB-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life2.5 hours
Toxicity
[]
Human - male:
- subcutaneous: 86 mg/kg
- subcutaneous: 429 μg/kg/2W-I
Human - female:
- subcutaneous: 120 μg/kg
- subcutaneous: 240 μg/kg/1H-I
- subcutaneous: 120 μg/kg
Rat:
- oral: >2 gm/kg
Mouse:
- oral: >500 mg/kg
- subcutaneous: >100 mg/kg

Sumatriptan

Sumatriptan (also known as Imitrex, Sumatran, Sumax, Imigran, Sumatriptanum, 1H-Indole-5-methanesulfonamide, 3-[2-(dimethylamino)ethyl]-N-methyl-, 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide, Imigran Recovery, 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide or 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide) is a substance of the phenylpropylamine class.

Chemistry

Salts []

Sumatriptan is typically found in the form of its succinate salt.

 []

Sumatriptan is a achiral mixture

Anodyne Usernotes
[]
0xea / Sumatriptan[succinate] via Intravenous at 5mg
  • warm uncomfortable panick inducing rush; burning sensation in my head immediately upon intravenous injection; ; relaxed cool and clear head feeling

Legal status []

  • Canada: Sumatriptan is a prescription only substance.
  • United Kingdom: Sumatriptan is a prescription only substance.
  • United States: Sumatriptan is a prescription only substance.[3][4][5]

See also []

  • Substituted phenylpropylamines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 5358, Sumatriptan. Accessed October 14, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/5358

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Sumatriptan. UNII: 8R78F6L9VO. Global Substance Registration System. Accessed October 14, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/8R78F6L9VO

    3. Imitrex- sumatriptan injection. February 8, 2023. Accessed October 14, 2025. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fee7d073-0b99-48f2-7985-0d8cf970894b

    4. Imitrex- sumatriptan spray. March 22, 2024. Accessed October 14, 2025. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cc11b09d-e6cc-4cf8-1495-5ac64d5aae5f

    5. Imitrex- sumatriptan tablet, film coated. February 21, 2024. Accessed October 14, 2025. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=584abe73-8290-4484-ff8e-5890831c095e