Anodyne| Selegiline | |
|---|---|
 | |
| Molecular structure via molpic based on CDK |
| Conformer [] | |
|---|---|
| Conformer structure via JSmol | |
| Physical properties [] | |
|---|---|
| Molecular mass | 187.28 g/mol [1] |
| Melting point | 141-142 °C [1] |
| Predicted LogP | 2.8 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C13H17N [1] |
| IUPAC name | (2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine [1] |
| SMILES | C[C@H](CC1=CC=CC=C1)N(C)CC#C [1] |
| InChI | InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1 [1] |
| InChIKey | MEZLKOACVSPNER-GFCCVEGCSA-N [1] |
| Dosing [] | |
|---|---|
| Elimination half-life | Oral:• Selegiline (single): 1.2 – 3.5 h• Selegiline (multi): 7.7 – 9.7 h• Desmethylselegiline (single): 2.2 – 3.8 h• Desmethylselegiline (multi): 9.5 h• Levomethamphetamine: 14 – 21 h• Levoamphetamine: 16 – 18 hOrally disintegrating tablet:• Selegiline (single): 1.3 h• Selegiline (multi): 10 hPatch:• Selegiline: 20 h[4] |
| Duration of action | Prolonged use:Oral: 2 – 3 days (Parkinson's disease relief) |
Selegiline
Selegiline (also known as (-)-selegiline, Selegilina, selgene, Selegilinum, (-)-Deprenil, Zalapar, Otrasel, Selegene, (R)-(-)-Selegiline or l-E 250) is a monoamine oxidase inhibitor substance of the amphetamine class.
Chemistry
Salts []
Selegiline is typically found in the form of its hydrochloride salt.
Stereochemistry []
Selegiline is a absolute mixture
Experience reports []
There are currently 3 experience reports involving selegiline on OpenErowid:
Legal status
- Australia: Selegiline is a S4 substance.
- Brazil: Selegiline is a C1 substance.[3]
- Canada: Selegiline is a prescription only substance.
- United Kingdom: Selegiline is a prescription only substance.
- United States: Selegiline is a prescription only substance.
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 26757, Selegiline. Accessed June 26, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/26757
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Selegiline. UNII: 2K1V7GP655. Global Substance Registration System. Accessed June 26, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/2K1V7GP655
Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed June 26, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992
EMSAM® (Selegiline Transdermal System) Label. Food and Drug Administration. July 1, 2017. Accessed June 26, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021336s014lbl.pdf