Anodyne

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Piperazine
Generated by the Chemistry Development Kit (http://github.com/cdk)
Salts
[]
Piperazine sulfate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Piperazine hydrobromide
Generated by the Chemistry Development Kit (http://github.com/cdk)
Piperazine phosphate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Piperazine tartrate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Piperazine adipate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Dipiperazine tricitrate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Piperazine camsilate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
[]
86.14 g/mol [1]
Density1.1 at 68 °F (NTP, 1992) - Denser than water; will sink g/cm3 [1]
AppearancePlates or leaflets from ethanol [1]
OdorTypical amine odor [1]
TasteSalty taste [1]
Melting point223 ° [1]
Boiling point295 ° [1]
DecompositionWhen heated to decomposition it emits highly toxic fumes of /nitrogen oxide/. [1]
SolubilityVery soluble (NTP, 1992) [1]
-1.5 [1]
Structural Identifiers
[]
C4H10N2 [1]
piperazine [1]
C1CNCCN1 [1]
InChI=1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2 [1]
InChIKeyGLUUGHFHXGJENI-UHFFFAOYSA-N [1]
Toxicity
[]
Human - child:
- oral: 75 mg/kg
Rat:
- oral: 1900 mg/kg
- subcutaneous: 3700 mg/kg
- intravenous: 1340 mg/kg
- intramuscular: >2500 mg/kg
Mouse:
- oral: 600 mg/kg
- intraperitoneal: 1900 mg/kg
- intravenous: 1180 mg/kg
Rabbit:
- skin: 4 mL/kg
Mouse:
- inhalation: 5400 mg/m3/2H

Piperazine

Piperazine (also known as Diethylenediamine, 1,4-Diazacyclohexane, Piperazin, Hexahydropyrazine, Piperazidine, Antiren, 1,4-Piperazine, Diethyleneimine, Pipersol or Eraverm) is a substance of the piperazine class.

Chemistry

Salts []

Piperazine is typically found in the form of its sulfate, hydrobromide, phosphate, tartrate, adipate, tricitrate and camsilate salts.

 []

Piperazine is a achiral mixture

See also []

  • Substituted piperazines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 4837, Piperazine. Accessed August 19, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/4837

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Piperazine. UNII: 1RTM4PAL0V. Global Substance Registration System. Accessed August 19, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/1RTM4PAL0V