Pholedrine

4-HMA

Salts []
Pholedrine hemisulfate

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	165.23 g/mol ^[1]
Predicted LogP	1.7 ^[1]

Structural Identifiers []
Molecular formula	C₁₀H₁₅NO ^[1]
IUPAC name	4-[2-(methylamino)propyl]phenol ^[1]
SMILES	CC(CC1=CC=C(C=C1)O)NC ^[1]
InChI	InChI=1S/C10H15NO/c1-8(11-2)7-9-3-5-10(12)6-4-9/h3-6,8,11-12H,7H2,1-2H3 ^[1]
InChIKey	SBUQZKJEOOQSBV-UHFFFAOYSA-N ^[1]

Pholedrine (also known as Pholedrine, Pulsotyl, Isodrine, Pressitan, Racemic pholedrine, Pholedrinum, 4-Hydroxy-N-methylamphetamine, p-(2-Methylaminopropyl)phenol, Isodrin or Oh-ma) is a sympathomimetic substance of the amphetamine class.

Chemistry

Salts []

Pholedrine is typically found in the form of its hemisulfate salt.

Stereochemistry []

Pholedrine is a racemic mixture of the enantiomers.

Stereoisomerism
(R)-Pholedrine (S)-Pholedrine
Stereoisomer enumberation with rdkit

Pharmacology

ATC Classification

Metabolism

Subjective effects []

class / Sympathomimetic

Physical effects
Abnormal heartbeat Dehydration Dry mouth Increased blood pressure Increased heart rate Restless legs Shakiness Stamina enhancement Vasoconstriction

Cognitive effects
Thought acceleration Wakefulness

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 4655, Pholedrine. Accessed April 14, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/4655
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pholedrine. UNII: AY28O44JGD. Global Substance Registration System. Accessed April 14, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/AY28O44JGD

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