Vyvanse

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	263.38 g/mol [1]
Appearance	Golden-colored solid from methanol [1]
Melting point	191-193 [1]
Solubility	White to off-white powder. MP 120-122 °C. Solubility in water: 792 mg/mL /Lisdexamfetamine dimethanesulfonate/ [1]
Predicted LogP	1.2 [1]

Structural Identifiers []
Molecular formula	C15H25N3O [1]
IUPAC name	(2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanamide [1]
SMILES	C[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)N [1]
InChI	InChI=1S/C15H25N3O/c1-12(11-13-7-3-2-4-8-13)18-15(19)14(17)9-5-6-10-16/h2-4,7-8,12,14H,5-6,9-11,16-17H2,1H3,(H,18,19)/t12-,14-/m0/s1 [1]
InChIKey	VOBHXZCDAVEXEY-JSGCOSHPSA-N [1]

Lisdexamphetamine

Lisdexamphetamine (also known as Lisdexamfetamine, lysine-d-amphetamine, lisdexanfetamina, lysine-dextroamphetamine, (2S)-2,6-Diamino-N-((1S)-1-methyl-2-phenylethyl)hexanamide, (2S)-2,6-Diamino-N-[(1S)-1-methyl-2-phenylethyl]hexanamide, (2S)-2,6-diamino-N-((2S)-1-phenylpropan-2-yl)hexanamide, lisdexamfetaminum, (2S)-2,6-diamino-N-((2S)-1-phenylpropan-2-yl)hexanimidic acid or (2S)-2,6-diamino-N-[(2S)-1-phenylpropan-2-yl]hexanimidic acid) is a codrug, prodrug and stimulant substance of the amphetamine class.

Chemistry

Pharmacology

ATC Classification

Metabolism

Lisdexamphetamine acts as a codrug for:

Metabolic pathways []
> Lisdexamphetamine Lysine Dextroamphetamine FMO3 FMO3 At normal urine pH, about 30–40% of amphetamine is excreted unchanged and roughly 50% is excreted as the inactive metabolites (bottom row).[2] The remaining 10–20% is excreted as the active metabolites.