Isotonitazepyne

Isotonitazepyne

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	408.5 g/mol ^[1]
Predicted LogP	4.5 ^[1]

Structural Identifiers []
Molecular formula	C₂₃H₂₈N₄O₃ ^[1]
IUPAC name	5-nitro-2-[(4-propan-2-yloxyphenyl)methyl]-1-(2-pyrrolidin-1-ylethyl)benzimidazole ^[1]
SMILES	CC(C)OC1=CC=C(C=C1)CC2=NC3=C(N2CCN4CCCC4)C=CC(=C3)[N+](=O)[O-] ^[1]
InChI	InChI=1S/C23H28N4O3/c1-17(2)30-20-8-5-18(6-9-20)15-23-24-21-16-19(27(28)29)7-10-22(21)26(23)14-13-25-11-3-4-12-25/h5-10,16-17H,3-4,11-15H2,1-2H3 ^[1]
InChIKey	VRKDSDBBRNHHCR-UHFFFAOYSA-N ^[1]

Isotonitazepyne (also known as N-Pyrrolidino Isotonitazene, 2-(4-isopropoxybenzyl)-5-nitro-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzimidazole or 1H-Benzimidazole, 2-[[4-(1-methylethoxy)phenyl]methyl]-5-nitro-1-[2-(1-pyrrolidinyl)ethyl]-) is a opioid substance of the nitazepyne class.

Chemistry

Stereochemistry []

Isotonitazepyne is a achiral mixture.

Subjective effects []

class / Opioid

Physical effects
Constipation Cough suppression Difficulty urinating Itchiness Nausea Pain relief Pupil constriction Respiratory depression Sedation Stomach cramp

Cognitive effects
Anxiety suppression Cognitive euphoria Compulsive redosing Increased music appreciation Thought deceleration

Visual effects
Double vision

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 168322631, Isotonitazepyne. Accessed June 7, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/168322631
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Isotonitazepyne. UNII: ERF4K35UV5. Global Substance Registration System. Accessed June 7, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/ERF4K35UV5

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