Anodyne

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Clotiazepam
Clotiazepam
Molecular structure via molpic based on CDK
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Physical properties
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318.8 g/mol [1]
Melting point105-106 [1]
Solubility5.37e-03 g/L [1]
3.5 [1]
Structural Identifiers
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C16H15ClN2OS [1]
5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one [1]
CCC1=CC2=C(S1)N(C(=O)CN=C2C3=CC=CC=C3Cl)C [1]
InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3 [1]
InChIKeyCHBRHODLKOZEPZ-UHFFFAOYSA-N [1]
Dosing
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Elimination half-life4 hours[4]

Clotiazepam

Clotiazepam (also known as Trecalmo, Rizen, Tienor, Clotiazepamum, Distensan, Clozan, Y 6047, 5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one or Y-6047) is a substance of the thienodiazepine class.

Chemistry

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Clotiazepam is a achiral mixture

Legal status []

  • Brazil: Clotiazepam is a B1 substance.[3]
  • Canada: Clotiazepam is a Schedule IV substance.
  • Germany: Clotiazepam is a prescription only/Anlage III substance.
  • United Kingdom: Clotiazepam is a Class C substance.
  • United States: Clotiazepam is a Schedule I under the "Controlled Substances Act (CSA)".

See also []

  • Substituted thienodiazepines
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 2811, Clotiazepam. Accessed June 26, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/2811

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Clotiazepam. UNII: ZCN055599V. Global Substance Registration System. Accessed June 26, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/ZCN055599V

    3. Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed June 26, 2025. https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992

    4. Clotiazépam. Economique et de Santé Publique. May 20, 2015. Accessed June 26, 2025. https://www.has-sante.fr/upload/docs/evamed/CT-14195_VERATRAN_PIC_REEVAL_RI_Avis2_CT14195.pdf