Anodyne

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Cetirizine
Cetirizine
Molecular structure via molpic based on CDK
Physical properties
[]
388.9 g/mol [1]
AppearanceCrystals from ethanol [1]
Melting point110-115°C [1]
1.7 [1]
Structural Identifiers
[]
C21H25ClN2O3 [1]
2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid [1]
C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl [1]
InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26) [1]
InChIKeyZKLPARSLTMPFCP-UHFFFAOYSA-N [1]
Dosing
[]
Elimination half-lifeMean: 8.3 hoursRange: 6.5 – 10 hours[6]
Duration of action≥24 hours

Cetirizine

Cetirizine (also known as Cetirizina, Cetryn, Ziptek, Setir, Cetirizinum, Cetirizin, Hitrizin Film Tablet, (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid, (2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid or Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-) is a substance of the carboxylic acid class.

Chemistry

Salts []

Cetirizine is typically found in the form of its hydrochloride salt.

 []

(RS)-Cetirizine is a racemic mixture of the optical stereoisomers

Anodyne Usernotes
[]
0xea / Cetirizine[hydrochloride] via OralSeamed too improve allergy symptoms

Legal status []

  • Australia: Cetirizine is a Unscheduled substance.
  • Canada: Cetirizine is a OTC substance.[3][4][5]
  • New Zealand: Cetirizine is a OTC substance.
  • United Kingdom: Cetirizine is a GSL substance.
  • United States: Cetirizine is a OTC substance.

See also []

  • Substituted carboxylic acids
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 2678, Cetirizine. Accessed June 26, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/2678

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Cetirizine. UNII: YO7261ME24. Global Substance Registration System. Accessed June 26, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/YO7261ME24

    3. Reactine Product information. January 24, 2007. Accessed June 26, 2025. https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=46803

    4. Reactine Product information. August 4, 1997. Accessed June 26, 2025. https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=11590

    5. Zyrtec Product information. July 5, 2001. Accessed June 26, 2025. https://health-products.canada.ca/dpd-bdpp/info?lang=eng&code=43974

    6. Simons FE. Comparative pharmacology of H1 antihistamines: clinical relevance. The American Journal of Medicine. December 1, 2002; 113(Suppl 9A):38S–46S.