Anodyne| Amoxapine | |
|---|---|
| Molecular structure via molpic based on CDK |
| Conformer [] | |
|---|---|
| Physical properties [] | |
|---|---|
| Molecular mass | 313.8 g/mol [1] |
| Melting point | 175-176 [1] |
| Solubility | 34.4 [ug/mL] (The mean of the results at pH 7.4) [1] |
| Predicted LogP | 2.6 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C17H16ClN3O [1] |
| IUPAC name | 8-chloro-6-piperazin-1-ylbenzo[b][1,4]benzoxazepine [1] |
| SMILES | C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl [1] |
| InChI | InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2 [1] |
| InChIKey | QWGDMFLQWFTERH-UHFFFAOYSA-N [1] |
| Toxicity [] | |
|---|---|
| TDLo | Human - male: - oral: 70 mg/kg/3W-I - oral: 4286 μg/kg - oral: 14 mg/kg - oral: 27 mg/kg - oral: 4285 μg/kg/2D- Human - child: - oral: 10 mg/kg Human - female: - oral: 5 mg/kg - oral: 17 mg/kg - oral: 15 mg/kg/5D-I - oral: 30 mg/kg - oral: 50 mg/kg |
| LDLo | Human - female: - oral: 40 mg/kg - oral: 40 mg/kg - oral: 75953 μg/kg Dog: - intraperitoneal: 20 mg/kg Human - child: - oral: 25 mg/kg |
| LD50 | Rat: - oral: 313 mg/kg - intraperitoneal: 201 mg/kg - subcutaneous: >4500 mg/kg Mouse: - oral: 104 mg/kg - subcutaneous: 385 mg/kg - intraperitoneal: 112 mg/kg |
Amoxapine
Amoxapine (also known as Asendin, Demolox, Amoxan, Desmethylloxapin, Amoxapina, Asendis, Amoxapinum, Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(1-piperazinyl)-, CL 67772 or CL-67772) is a
Chemistry
Stereochemistry []
Amoxapine is a achiral mixture
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 2170, Amoxapine. Accessed August 14, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/2170
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Amoxapine. UNII: R63VQ857OT. Global Substance Registration System. Accessed August 14, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/R63VQ857OT