Mephedrene

Molecular structure via molpic based on CDK

Conformer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	169.29 g/mol ^[1]
Predicted LogP	2.3 ^[1]

Structural Identifiers []
Molecular formula	C₉H₁₅NS ^[1]
IUPAC name	N-methyl-1-(5-methylthiophen-2-yl)propan-2-amine ^[1]
SMILES	CC1=CC=C(S1)CC(C)NC ^[1]
InChI	InChI=1S/C9H15NS/c1-7(10-3)6-9-5-4-8(2)11-9/h4-5,7,10H,6H2,1-3H3 ^[1]
InChIKey	HZICDJQMPRFRKC-UHFFFAOYSA-N ^[1]

Mephedrene

Mephedrene (also known as 5-Methylmethiopropamine, 5-Mmpa, 2-Thiopheneethanamine, N,α,5-trimethyl- or 2-Thiopheneethanamine, n,α,5-trimethyl-) is a stimulant substance of the thiopropamine class.

Chemistry

Stereochemistry []

Mephedrene is a racemic mixture of the optical stereoisomers

Stereoisomers
(+)-Mephedrene (-)-Mephedrene

Subjective effects []

Physical effects
Abnormal heartbeat Appetite suppression Dehydration Dry mouth Increased blood pressure Increased heart rate Increased libido Restless legs Shakiness Stamina enhancement Stimulation Teeth grinding Vasoconstriction

Cognitive effects
Analysis enhancement Cognitive euphoria Compulsive redosing Disinhibition Ego inflation Focus enhancement Increased music appreciation Mania Motivation enhancement Suggestibility suppression Thought acceleration Wakefulness

Legal status []

Germany: Mephedrene is a Neuer-Psychoaktiver-Stoff under the "Neue-psychoaktive-Stoffe-Gesetz (NpSG)".
United Kingdom: Mephedrene is a PSA substance.

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 64487873, Mephedrene. Accessed July 13, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/64487873
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Mephedrene. UNII: ZP92FK3KK5. Global Substance Registration System. Accessed July 13, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/ZP92FK3KK5

Anodyne