Clonidine
| Clonidine | |
|---|---|
 |
| Salts [] | |
|---|---|
| Clonidine hydrochloride | |
| Molecular structure via molpic based on CDK |
| Physical properties [] | |
|---|---|
| Molecular mass | 230.09 g/mol [1] |
| Appearance | Crystals [1] |
| Melting point | 130 °C [1] |
| Decomposition | When heated to decomposition it emits toxic fumes of nitroxides and /hydrogen chloride/. /Clonidine hydrochloride/ [1] |
| Solubility | Insoluble in water [1] |
| Predicted LogP | 1.6 [1] |
| Structural Identifiers [] | |
|---|---|
| Molecular formula | C9H9Cl2N3 [1] |
| IUPAC name | N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine [1] |
| SMILES | C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl [1] |
| InChI | InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14) [1] |
| InChIKey | GJSURZIOUXUGAL-UHFFFAOYSA-N [1] |
| Pharmacokinetics[] | |
|---|---|
| Elimination half-life | IR: 12 – 16 hours; 41 hours in kidney failure, 48 hours for repeated dosing |
| Duration of action | Blood pressure: ≤ 8 hours ADHD: 4 – 8 hours[4] |
| Dosing[] |
|---|
| Oral [] | |
|---|---|
| Light | ≤ 0.1 mg(5x - 71.4%) |
| Common | 0.1 mg |
| Strong | 0.1 - 0.2 mg |
| Heavy | 0.2 mg(2x - 28.6%) |
| Extreme | 0.2 mg + |
Statistically derived dosages via DBI-IGS We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly. |
Clonidine (also known as Clonidine, Clonidin, N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, Chlornidinum, Catapres-TTS, ST-155-BS, Catapresan, Catapressan, Clonidina or ST 155BS) is a
Chemistry
Salts []
Clonidine is typically found in the form of its hydrochloride salt.
Stereochemistry []
Clonidine is a achiral mixture.
Pharmacology
ATC Classification
In the nervous system (N) clonidine acts In the cardiovascular system (C) clonidine acts In the sensory organs (S) clonidine acts as a analgesic (N02), antimigraine preparation (N02C), clonidine (N02CX02) and other antimigraine preparation (N02CX).[1]Metabolism
Subjective effects []
Legal status []
- Australia: Clonidine is a S4 substance.[3]
- Canada: Clonidine is a prescription only substance.
- United Kingdom: Clonidine is a prescription only substance.
- United States: Clonidine is a prescription only substance.
See also []
External links []
References []
National Center for Biotechnology Information. PubChem Compound Summary for CID 2803, Clonidine. Accessed April 16, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/2803
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Clonidine. UNII: MN3L5RMN02. Global Substance Registration System. Accessed April 16, 2026. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/MN3L5RMN02
CATAPRES clonidine hydrochloride 150 microgram/1mL injection ampoule (17919). August 12, 2022. Accessed April 16, 2026. https://www.tga.gov.au/resources/artg/17919
Efron D, Coscini N. Pharmacological management of attention deficit hyperactivity disorder in children and adolescents. Australian Prescriber. October 14, 2025; 48(5)