Anodyne

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Amlodipine
Generated by the Chemistry Development Kit (http://github.com/cdk)
Salts
[]
Amlodipine besylate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Amlodipine adipate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Amlodipine maleate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Amlodipine mesylate
Generated by the Chemistry Development Kit (http://github.com/cdk)
(-)-Amlodipine malate
Generated by the Chemistry Development Kit (http://github.com/cdk)
Molecular structure via molpic based on CDK
Physical properties
[]
408.9 g/mol [1]
Melting point199-201 [1]
DecompositionHazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx), sulfur oxides, hydrogen chloride gas. /Amlodipine besylate/ [1]
Solubilityslightly soluble in water [1]
3 [1]
Structural Identifiers
[]
C20H25ClN2O5 [1]
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate [1]
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN [1]
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3 [1]
InChIKeyHTIQEAQVCYTUBX-UHFFFAOYSA-N [1]
Pharmacokinetics[]
Elimination half-life30 – 50 hours
Duration of actionAt least 24 hours
Toxicity
[]
Human - female:
- oral: 600 μg/kg/3D-I
Human - child:
- oral: 400 μg/kg
Human - female:
- oral: 1400 μg/kg

Amlodipine

Amlodipine (also known as Amlodipino, Amlodipinum, Amlodipine Free Base, 3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, HGP0904, HGP-0904, Ckd-330 component amlodipine, 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester or O3-ethyl O5-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate) is a substance of the carboxylic acid class.

Chemistry

Salts []

Amlodipine is typically found in the form of its besylate, adipate, maleate, mesylate and malate salts.

 []

Amlodipine is a racemic mixture of the

Stereoisomers
(S)-AmlodipineGenerated by the Chemistry Development Kit (http://github.com/cdk)
(R)-AmlodipineGenerated by the Chemistry Development Kit (http://github.com/cdk)
Anodyne Usernotes
[]
0xea / Amlodipine[besylate] via Oral at 5mg oral
    -

Legal status []

  • Australia: Amlodipine is a S4 substance.
  • Canada: Amlodipine is a prescription only substance.
  • United Kingdom: Amlodipine is a prescription only substance.
  • United States: Amlodipine is a prescription only substance.
  • European Union: Amlodipine is a prescription only substance.

See also []

  • Substituted carboxylic acids
  • Anodyne

    • External links []

    References []

    1. National Center for Biotechnology Information. PubChem Compound Summary for CID 2162, Amlodipine. Accessed September 7, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/2162

    2. U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Amlodipine. UNII: 1J444QC288. Global Substance Registration System. Accessed September 7, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/1J444QC288