2-Methylbucinnazine

2-Methyl-AP-237

Molecular structure via molpic based on CDK

Physical properties []
Molecular mass	286.4 g/mol ^[1]
Predicted LogP	2.9 ^[1]

Structural Identifiers []
Molecular formula	C₁₈H₂₆N₂O ^[1]
IUPAC name	1-[2-methyl-4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]butan-1-one ^[1]
SMILES	CCCC(=O)N1CCN(CC1C)C/C=C/C2=CC=CC=C2 ^[1]
InChI	InChI=1S/C18H26N2O/c1-3-8-18(21)20-14-13-19(15-16(20)2)12-7-11-17-9-5-4-6-10-17/h4-7,9-11,16H,3,8,12-15H2,1-2H3/b11-7+ ^[1]
InChIKey	CRSFXYZFNAFVFC-YRNVUSSQSA-N ^[1]

2-Methylbucinnazine (also known as Methyl-AP-237, Bucinnazine, 2-methyl, 2-Methyl-ap-237, 1-Butanone, 1-(2-methyl-4-(3-phenyl-2-propen-1-yl)-1-piperazinyl)-, 2-methyl AP-237, Schembl10998925 or Dea no. 9664) is a substance of the 1-cinnamylpiperazine class.

Chemistry

Stereochemistry []

2-Methylbucinnazine is a racemic mixture of the enantiomers.

Stereoisomerism
(S)-2-Methylbucinnazine (R)-2-Methylbucinnazine
Stereoisomer enumberation with rdkit

Druglikeness

Lipinski's rule of five

2-Methylbucinnazine matches Lipinski's rule of five.

Subjective effects []

0xea / 2-Methylbucinnazine []
Routes: Intravenous (0.75 - 10mg) Onset: 5 - 10 s Comeup: 30 s Duration: ? Oral (50mg) Salts: Hydrochloride Source: 2-Methyl-AP-237: Research-chemical-vendor Netherlands Effects: nausea Notes: Does not substitute for fentanyl

0xea / 2-Methylbucinnazine []

Routes:

Intravenous (0.75 - 10mg)
Onset: 5 - 10 s
Comeup: 30 s
Duration: ?
Oral (50mg)

Salts:

Hydrochloride

Source:

2-Methyl-AP-237: Research-chemical-vendor Netherlands

Effects:

nausea

Notes:

Does not substitute for fentanyl

External links []

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 6447699, 2-Methylbucinnazine. Accessed June 16, 2026. https://pubchem.ncbi.nlm.nih.gov/compound/6447699

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