{"Abbreviation":"LVM","Aliases":["Racemethorphan","3-Methoxy-17-methylmorphinan","Dextromethorphan-d3","Racemethorphane","Racemetorfano","Racemethorphanum","Deoxydihydrothebacodine","avp-786","IDS-NR-001","DL-3-Methoxy-N-methylmorphinan"],"CAS":"510-53-2","ChEBI":"CHEBI:146178","ChEMBL":"CHEMBL22207","ChemicalClasses":["morphinan"],"Dosing Info":[],"DrugClasses":[],"European Community (EC) Number":"208-114-4","FullSalts":["methorphan hydriodide","methorphan salicylate","methorphan hydrochloride","methorphan hydrobromide"],"HMDB ID":"HMDB0242610","HeavyAtomCount":20,"IUPACName":"4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene","InChI":"InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3","InChIKey":"MKXZASYAUGDDCJ-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)","MolecularFormula":"C\u003csub\u003e18\u003c/sub\u003eH\u003csub\u003e25\u003c/sub\u003eNO","MolecularWeight":"271.4 g/mol","PubChemId":3008,"Record Description":["6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene is an organic heterotetracyclic compound that is 1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene which is substituted by a methoxy group at position 6 and a methyl group at position 11. It is an aromatic ether, a morphinane alkaloid, a morphinane-like compound and an organic heterotetracyclic compound.","Racemethorphan is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence. It is a Opiates substance.","Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.","See also: Dextromethorphan (annotation moved to).","6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene is an organic heterotetracyclic compound that is 1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene which is substituted by a methoxy group at position 6 and a methyl group at position 11. It is an aromatic ether, a morphinane alkaloid, a morphinane-like compound and an organic heterotetracyclic compound."],"References":[{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q6823902","Name":"methorphan","Sub":false},{"Link":"https://www.wikidata.org/wiki/Q407781","Name":"(+)-methorphan","Sub":true},{"Link":"https://www.wikidata.org/wiki/Q60998690","Name":"(-)-methorphan","Sub":true}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3008","Name":"methorphan","Sub":false},{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5360696","Name":"(+)-methorphan","Sub":true},{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5362449","Name":"(-)-methorphan","Sub":true}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL22207","Name":"methorphan","Sub":false},{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL52440","Name":"(+)-methorphan","Sub":true},{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1908323","Name":"(-)-methorphan","Sub":true}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:146178","Name":"methorphan","Sub":false},{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4470","Name":"(+)-methorphan","Sub":true},{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:146176","Name":"(-)-methorphan","Sub":true}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=510-53-2","Name":"methorphan","Sub":false},{"Link":"https://commonchemistry.cas.org/detail?cas_rn=125-71-3","Name":"(+)-methorphan","Sub":true},{"Link":"https://commonchemistry.cas.org/detail?cas_rn=125-70-2","Name":"(-)-methorphan","Sub":true}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0242610","Name":"methorphan","Sub":false},{"Link":"https://hmdb.ca/metabolites/HMDB0001920","Name":"(-)-methorphan","Sub":true}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID60859238","Name":"methorphan","Sub":false},{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022908","Name":"(+)-methorphan","Sub":true},{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID20872403","Name":"(-)-methorphan","Sub":true}]}],"SMILES":"CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC","Salts":["hydriodide","salicylate","hydrochloride","hydrobromide"],"SaltsAcidCount":[0,0,1,1],"SaltsAmineCount":[1,1,1,1],"SaltsUNII":["086F8ZEM77","B2F298X1AJ","351KFH969D","9D2RTI9KYH"],"Stereoisomers":["(+)-methorphan","(-)-methorphan"],"StereoisomersUNII":["7355X3ROTS","8YB8F78WM1"],"StructureBase64":"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