{"ATC Code":"N05CF01","Abbreviation":[],"Aliases":["Imovane","Zimovane","Amoban","Zopiclona","Zopiclonum","Ximovan","RP-27267","RP 27267","[6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate","Zimovane LS","Zileze 7.5","Zileze 3.75","1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo(3,4-b)pyrazin-5-yl ester","1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester","Limovan","Zopiclon-ratiopharm","6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methyl-1-piperazinecarboxylate","6-(5-chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine","6-(5-Chloropyrid-2-yl)-5-(4-methylpiperazin-1-yl)carbonyloxy-7-oxo-6,7-dihydro-5h-pyrrolo(3,4-b)pyrazine","(6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo(3,4-b)pyrazin-7-yl) 4-methylpiperazine-1-carboxylate","4-Methyl-piperazine-1-carboxylic acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl ester","4-Methyl-piperazine-1-carboxylic acid 6-(5-chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl ester","6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazin-5-yl 4-methyl-1-piperazinecarboxylate","6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo(3,4-b)pyrazin-5-yl 4-methylpiperazine-1-carboxylate","6-(5-chloropyridin-2-yl)-7-oxo-5H,6H,7H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate"],"Biological Half-Life":"Elimination half life is approximately 5 hours (range 3.8 to 6.5 hours) and is prolonged to 11.9 hours in patients with hepatic insufficiency.","CAS":"43200-80-2","ChEBI":"CHEBI:32315","ChEMBL":"CHEMBL135400","ChemicalClasses":["racetam"],"Chirality":"racemic","DBI-IGS":"Zopiclone","DEA no":2784,"Dosing Info":[{"Method":"Sublingual","Tiers":{"Common":{"Lower":6.8,"Unit":"mg","Upper":8.8},"Extreme":{"Lower":14.7,"Unit":"mg","Upper":14.7},"Heavy":{"Lower":10,"Unit":"mg","Upper":14.7},"Light":{"Lower":6.8,"Unit":"mg","Upper":6.8},"Strong":{"Lower":8.8,"Unit":"mg","Upper":10}}},{"Method":"Oral","Tiers":{"Common":{"Lower":13.2,"Unit":"mg","Upper":20},"Extreme":{"Lower":30,"Unit":"mg","Upper":30},"Heavy":{"Lower":22.5,"Unit":"mg","Upper":30},"Light":{"Lower":13.2,"Unit":"mg","Upper":13.2},"Strong":{"Lower":20,"Unit":"mg","Upper":22.5}}}],"Drug Classes":"Breast Feeding; Lactation; Milk, Human; Hypnotics and Sedatives","Drug Indication":"For the short-term treatment of insomnia.","EINECS":"256-138-9","EliminationHalfLife":"~5 hours (3.5 – 6.5 hours) ~7 – 9 hours for 65+ years old","Esters":[],"European Community (EC) Number":"256-138-9","Formating":[],"HMDB ID":"HMDB0015329","Health Effects":"They cause slurred speech, disorientation and \"drunken\" behavior. They are physically and psychologically addictive.","HeavyAtomCount":27,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Hypnotics and Sedatives","IUPACName":"[6-(5-chloro-2-pyridinyl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate","Impurities":["zopiclone n-oxide","rp-29307","rp-48497"],"InChI":"InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3","InChIKey":"GBBSUAFBMRNDJC-UHFFFAOYSA-N","LD50":[{"dosages":[{"amount":"827 mg/kg","route":"oral"},{"amount":"771 mg/kg","route":"intraperitoneal"},{"amount":"540 mg/kg","route":"subcutaneous"},{"amount":"280 mg/kg","route":"intravenous"},{"amount":"295 mg/kg","route":"intramuscular"}],"organism":"Rat"},{"dosages":[{"amount":"2174 mg/kg","route":"oral"},{"amount":"1325 mg/kg","route":"intraperitoneal"},{"amount":"888 mg/kg","route":"subcutaneous"},{"amount":"321 mg/kg","route":"intravenous"},{"amount":"541 mg/kg","route":"intramuscular"}],"organism":"Mouse"}],"MeSH Pharmacological Classification":"Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.","Melting Point":"178 °C","MolecularFormula":"C\u003csub\u003e17\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eClN\u003csub\u003e6\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"388.8 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Zopiclone is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia. While Zopiclone is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABA\u003csub\u003eB\u003c/sub\u003eZ) receptor complex. Subunit modulation of the GABA\u003csub\u003eB\u003c/sub\u003eZ receptor chloride channel macromolecular complex is hypothesized to be responsible for some of the pharmacological properties of benzodiazepines, which include sedative, anxiolytic, muscle relaxant, and anticonvulsive effects in animal models. Zopiclone binds selectively to the brain alpha subunit of the GABA A omega-1 receptor.","Physical Description":"Solid","PubChemId":5735,"RefChem":"196249","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Zopiclone","Name":"Zopiclone","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q220426","Name":"Zopiclone","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01198","Name":"Zopiclone","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5735","Name":"Zopiclone","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL135400","Name":"Zopiclone","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32315","Name":"Zopiclone","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=43200-80-2","Name":"Zopiclone","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015329","Name":"Zopiclone","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D01372","Name":"Zopiclone","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/03A5ORL08Q","Name":"Zopiclone","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4041155","Name":"Zopiclone","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5735, Zopiclone. Accessed October 14, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5735\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5735\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Zopiclone. UNII: 03A5ORL08Q. Global Substance Registration System. Accessed October 14, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/03A5ORL08Q\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/03A5ORL08Q\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed October 14, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"SMILES":"CN1CCN(CC1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl","SaltData":[{"AcidCount":1,"Amine":"Zopiclone","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 149.662 114.959\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h150v115H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m125.753 55.022-11.233-3.619M110.425 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