{"Absorption, Distribution and Excretion":"Tritium radioactivity in mouse fetus taken from the pregnant female mouse which had been given tritium containing drinking water was measured to estimate the absorbed radiation dose from the incorporated tritium. BC3F1 female mice mated with ICR male were given drinking water containing various concentrations of tritium for whole pregnant period, from the morning when the vaginal plug was observed to the day just before term. At various times of the pregnant period, blood and fetuses were taken from the female mice to measure the tritium concentration using a Packard model of sample oxidizer. The absorbed radiation dose of the fetus from the incorporated tritium was estimated on the basis of the tritium concentration measured. The tritium concentration of the embryos increased gradually from the first pregnant day to reach the plateau level at the 7 to 9th day. The estimated radiation dose increased almost linearly depending on the tritium concentration in the drinking water. /Tritium containing drinking water/","Aliases":["Water","Distilled water","Dihydrogen oxide","Purified water","Sterile water","Water vapor","Water, deionized","aqua","Water, purified","Water, mineral","Dihydrogen Monoxide","steam","Deionized water","DHMO","Water, sterile","Water, distilled","Water for injection","Sterile purified water","Water for hemodialysis","Water purified","Sterile water for irrigation","Pur-wash","Water, purified sterile","Water, sterile purified","Ultrex ii ultrapure","Sterile water for injection","Sterile water for inhalation","Water for inhalation, sterile","Sterile water in plastic container","Water for injection, sterile","Water for irrigation, sterile","NSC-147337","Bacteriostatic water for injection","Water for injection, bacteriostatic","Sterile water for injection in plastic container","Bacteriostatic water for injection in plastic container","Dtxsid6026296","R-718","Chebi:15377","Water, distilled, conductivity or of similar purity","Drinking Water","B1217","Mineral Water","Water, Drinking","Water, Bottled","Water, Potable","Eyewash","Ocufresh","Salinaax","Winrevair","Bouton","Steams","water injection","Water solution","Dynamic Eyewash","Eye Irrigating","Redu mineral","Sterile Diluent","Water Additive","Dorama-neo","Eyewash additive","Neutral-Eyes","Real Eyewash","Water Vapors","Xpect Eyewash","Bio rock water","Eye Stream","Eyewash Solution","Rock Water","AeroWash Eyewash","Eye Clean","Bouton Eye Wash","Eye Wash","Leader Eye Wash","Vapors, Water","Rugby Eye Wash","Vapor, Water","Boraqua Eye Wash","Pivetal Eye Wash","Buffered Eye-lert","Eys Eye Wash","Firstep Firstflush","ULINE Eyewash","Fendall Pure Flow","gel relajante CBD","Salinaax Eye Wash","Scienceware Eyewash","ECOLAB Eye Wash","A-Med","Bacteriostatic Water","Rite Aid Eye Wash","Eyesaline Concentrate","DANGTTEOL","Ionized Alkali Water","Plus Rinse Emergency","Eyes Alive Eye Wash","Haws Eyewash Additive","Family Care Eye Wash","Nourishing hair","Plum Emergency Eyewash","Sterile Saline Eyewash","Crane Safety Eye Wash","Industrial Neutral-eyes","Thompson Safety Eyewash","Black hair serum","Mugwort sunscreen","Quality Choice Eye Wash","Veterinary Sterile Water","Skincare sunscreen","Eyewash Flushing Solution","Sperian Eyesaline Eyewash","Sterile Eyesaline Eyewash","Purified Water 98.3%","RapidCare Sterile Eyewash","Opthalmic Solution Eyewash","Prinzing Eye Wash Station","Eyesaline Emergency Eyewash","Honeywell Sterile Eyesaline","Kollourion Eyesalve Eyewash","Opticlear Sterile Eye Wash","Plum Duo Emergency Eyewash","Fendall 2000 Pure Flow","Water-fit sun serum","Dynamic Eyewash with Eyecup","Thesafetydirector Aquapreserv","Easy Care First Aid Eyewash","Eyesaline Eyewash Concentrate","pH Neutral Emergency Eyewash","Plus Rinse Emergency Eyewash","Advanced Eye Relief Eye Wash","Bach Original Flower Remedies","Fad First Aid Direct Eyewash","Sterile Diluent for Remodulin","Dtxcid106296","Medi-first First Aid Eye Wash","Aerowash Eyewash and Skin-rinse","Green Guard First Aid Eye Wash","Medics Choice Soothing Eye Wash","Sterile Diluent for Treprostinil","Sterile Isotonic Saline Solution","Xpect First Aid Buffered Eyewash","Emergency Eye Wash, PW, Sterile","Salinaax Eye Wash and Skin Flush","Sperian Water Additive Concentrate","Sperian Eyesaline Emergency Eyewash","Insulin Diluting Medium for NovoLog","Walgreens Sterile Soothing Eye Wash","Medi-first Plus First Aid Eye Wash","Well and Good Eye Rinse and Cleaner","Air Polymer-Type A Intrauterine Foam","Plum Emergency Eyewash Ph Neutralizing","Eyesaline Emergency Eyewash Concentrate","Veterinary Sterile Water for Irrigation","Xpect First Aid Buffered Eye and Skin","Bach Original Flower Remedies Rock Water","Physicianscare Ophthalmic Solution Eyewash","Sterile Isotonic Buffered Genuine Eyewash","A-med Brand First Aid Eye and Skin-rinse","Emergency First Aid Eyewash Purified Water","Plum Duo Emergency Eyewash Ph Neutralizing","Emergency Eye Wash, Pw, Sterile Ster-aide","Fad First Aid Direct Buffered Eye and Skin","Honeywell Sterile Eyesaline Emergency Eyewash","Plum Emergency Eyewash/Eyewash DUO/Eyewash Shower ISS USA","Physicianscare Ophthalmic Solution Eyewash Purified Water, 98.3%","Plum pH Neutral Emergency Eyewash/Emergency Eyewash DUO/Emergency Eyewash Shower ISS USA","231-791-2","686-299-4","hydron;hydroxide","Opticlear","Bac Water","CCRIS 6115","Aqua Purificata","H2O","Water, HPLC","Water, HPLC grade","Water, DEPC-Treated","Deuterium Cdepleted water","Mfcd00011332","Water, for HPLC","Water; Dihydrogen oxide","Nsc 147337; r 718","HOH","agua","1,3-epoxy-","Crackle Test Reference Standard: 0 wt% H2O in 10W30 Motor Oil","Water, sterile-filtered, BioReagent, suitable for cell culture","Crackle Test Reference Standard: 0.1 wt% H2O in 10W30 Motor Oil","Crackle Test Reference Standard: 0.5 wt% H2O in 10W30 Motor Oil","Crackle Test Reference Standard: 1.0 wt% H2O in 10W30 Motor Oil","Einecs 231-791-2","NSC 147337","acqua","dihydridooxygen","Unii-059qf0ko0r","Adelheidsquelle","Wiesbaden","Wasser","Water,deionized","Water,distilled","Water,sanitized","Adelheid aqua","Aqua adelheid","Aqua wiesbaden","Water,purified","Water,sterile","Wiesbaden aqua","Aqua wildbad","Deionised Water","Wildbad aqua","water-","DI water","HSDB 8183","hydrogen hydroxide","Qvgxllkocukjst-uhfffaoysa-n","Aqua pro injectione","eau","Pure Water Density Standard, UKAS ISO/IEC17025 and ISO Guide 34 certified, density: 0.9982 g/mL at 20 C, density: 0.9970 g/mL at 25 C","Water,bacteriostatic","Water for injections","Water, ACS reagent","Water, HPLC Plus","Water, LCMS grade","AQUAFINA","Water, PCR Reagent","Water, LC/MS","Water, Endotoxin-free","Water, for HPLC-MS","Water/eau/aqua","Water, double distilled","an unknown oxygen source","H-OH","ddWater","Water, for TOC analysis","SCHEMBL624","SCHEMBL822","Water pound WFI pound(c)","Distilled water, for HPLC","InChI=1/H2O/h1H2","Water, RNase, DNase-free","Schembl2523","Pure Water Density Standard","Sterile water for injections","Water for irrigation,sterile","Water, HPLC gradient grade","Water, demineralized, p.A.","very long chain fatty alcohol","very long-chain fatty alcohol","Water,bacteriostatic injection","Water, for ion chromatography","Water,Reagent(Deionizedwater)","Hydrogen oxide","Density Standard 998 kg/m3","very long chain fatty alcohols","very long-chain fatty alcohols","Aqua sterilisata pro injectione","Water, ultrapure, HPLC Grade","Water, BioPerformance Certified","Chembl1098659","Water, Molecular Biology Reagent","Xlyofnoqvpjjnp-uhfffaoysa-","diethylpyrocarbonate-treated Water","Chebi:197504","Tujkjamukrirhc-uhfffaoysa-n","Water, Reagent","[OH2]","Water, tested according to Ph.Eur.","NSC147337","Purified water in containers","Akos015950726","E-Toxate(TM) Water, endotoxin, free","Water with 0.1% trifluoroacetic acid","DB09145","Water, for UHPLC, for mass spectrometry","AS-89676","Distilled water, Laboratory reagent grade","Q283","Synthetic Fresh Water Stds 80-100 ppm","Water for injection in containers","NS00076359","Sterile purified water in containers","Water, ACS reagent, for ultratrace analysis","Water, packaged for use in deposition systems","C00001","D00001","F600024","Q274959","Q427071","Water, for HPCE, for luminescence, for UV-spectroscopy","Density Standard 998 kg/m3, H\u0026D Fitzgerald Ltd. Quality","Water, for molecular biology, DEPC-treated and sterile filtered","Acetylene intermix (1 per cent) in nitrogen Impurity E","Carbon monoxide intermix (5 per cent) in nitrogen Impurity A","Water, 99.999%, contained in 50 ml Swagelok? cylinder for CVD/ALD","Water, deionized 18 megaohm ASTM Type I, suitable for trace metal analysis","Water, for cell biology, free of endotoxins, ultrafiltered and autoclaved","Water, for embryo transfer, sterile-filtered, BioXtra, suitable for mouse embryo","8O","OH2"],"Boiling Point":"212 °","CAS":"7732-18-5","Chemical Classes":"Other Classes -\u003e Other Inorganic Compounds","ChemicalClasses":[],"Chirality":"achiral","Color/Form":"Colorless liquid","Density":"1 g/cm\u003csup\u003e3\u003c/sup\u003e","Drug Indication":"For diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered.","Esters":[],"European Community (EC) Number":"231-791-2","Formating":[],"HMDB ID":"HMDB0002111","HeavyAtomCount":1,"Human Drugs":"FDA approved drugs -\u003e Active ingredient","IUPACName":"oxidane","InChI":"InChI=1S/H2O/h1H2","InChIKey":"XLYOFNOQVPJJNP-UHFFFAOYSA-N","Interactions":"Because groundwater contamination is an important environmental concern, we examined the hepatic and renal effects of repeated exposure to a mixture of 25 chemicals frequently found in groundwater near hazardous-waste disposal sites and the effect of such exposure on carbon tetrachloride (CCI4) toxicity. Adult male F-344 rats received ad libitum deionized water and feed (Ad Lib Water) or ad libitum 10% MIX (referring to 10% of a technically achievable stock mixture) and feed for 14 d. Because exposure to the 25-chemical mixture via the drinking water resulted in decreased water and feed consumption, restricted deionized water and feed controls (Restricted Water) were included. On d 14, rats were gavaged with 0, 0.0375, 0.05, 0.075 or 0.15 mL CCl4/kg, and hepatic and renal toxicity assessed 24 hr later. Little or no hepatic and renal toxicity was observed in rats exposed to 10% MIX alone. No hepatic or renal lesions occurred that could be attributed to 10% MIX alone. Slight but statistically significant alterations, of uncertain biological significance, resulted from the water treatments: 10% MIX increased alanine aminotransferase, urea nitrogen (BUN), and BUN/creatinine ratio; Restricted Water increased 5'-nucleotidase and decreased alkaline phosphatase. Relative kidney weight was increased by both 10% MIX and Restricted Water. CCI4 resulted in significant dosage-dependent hepatotoxicity in all three water treatment groups but had little or no effect on renal indicators of toxicity. Relative to Ad Lib Water, significantly greater hepatotoxicity occurred in both 10% MIX and Restricted Water rats. The response to CCI4 in the Restricted Water rats was similar to that of 10% MIX rats, indicating that a substantial portion of the effect of 10% MIX on CCI4 hepatotoxicity is due to decreased water and feed intake.","KEGG Entries":[{"Id":"D00001","Interactions":[],"Synonyms":["Water","Purified water","Purified water in containers","Water, purified","Sterile purified water in containers","Water for injection","Water for injection in containers"]},{"Id":"D00001","Interactions":[],"Synonyms":["Water","Purified water","Purified water in containers","Water, purified","Sterile purified water in containers","Water for injection","Water for injection in containers"]},{"Id":"D00001","Interactions":[],"Synonyms":["Water","Purified water","Purified water in containers","Water, purified","Sterile purified water in containers","Water for injection","Water for injection in containers"]},{"Id":"D00001","Interactions":[],"Synonyms":["Water","Purified water","Purified water in containers","Water, purified","Sterile purified water in containers","Water for injection","Water for injection in containers"]}],"MeSH Headers":[{"Id":"M0020465","Link":"https://id.nlm.nih.gov/mesh/M0020465.html","Name":"Steam","Ref":127},{"Id":"M0022883","Link":"https://id.nlm.nih.gov/mesh/M0022883.html","Name":"Water","Ref":128},{"Id":"M0555397","Link":"https://id.nlm.nih.gov/mesh/M0555397.html","Name":"Drinking Water","Ref":129},{"Id":"M0521556","Link":"https://id.nlm.nih.gov/mesh/M0521556.html","Name":"Water Vapor","Ref":130},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":132},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":158}],"Melting Point":"32 °","MolecularFormula":"H\u003csub\u003e2\u003c/sub\u003eO","MolecularWeight":"18.015 g/mol","Non-Human Toxicity Values":"LD50 Mice ip 25000 mg/kg","Odor":"Odorless","Physical Description":"Water appears as a clear, nontoxic liquid composed of hydrogen and oxygen, essential for life and the most widely used solvent. Include water in a mixture to learn how it could react with other chemicals in the mixture.","PubChemId":962,"Records":{"UNII":{"Impurities":[]}},"RefChem":"116","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Water","Name":"Water","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB09145","Name":"Water","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/962","Name":"Water","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=7732-18-5","Name":"Water","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0002111","Name":"Water","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C00001","Name":"Water","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/059QF0KO0R","Name":"Water","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID6026296","Name":"Water","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 962, Water. Accessed April 20, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/962\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/962\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Water. UNII: 059QF0KO0R. Global Substance Registration System. Accessed April 20, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/059QF0KO0R\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/059QF0KO0R\u003c/a\u003e"],"SMILES":"O","SaltData":[],"Salts":[],"Solubility":"Completely miscible","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 12.449 7.58\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke-linecap=\"round\" stroke-linejoin=\"round\"\u003e\u003cpath fill=\"#fff\" d=\"M0 0h13v8H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"atom\"\u003e\u003cpath d=\"M11.889 3.078q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881T9.645.56q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M4.305 5.531h-.62V3.245H1.173v2.286H.56v-4.9h.613v2.072h2.512V.631h.62zM6.809 7.02H4.866v-.3l.772-.778q.221-.222.371-.393.154-.175.232-.34.079-.167.079-.364 0-.243-.147-.368-.142-.128-.371-.128-.214 0-.379.075-.16.075-.328.207l-.193-.243q.171-.147.393-.247.225-.1.507-.1.411 0 .65.208.239.207.239.575 0 .228-.096.432-.093.2-.264.396-.168.197-.393.418l-.615.604v.018h1.486z\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Taste":"Tasteless","Title":"Water","UNII":"059QF0KO0R","Wikipedia":"Water","XLogP":-0.5}