{"ATC Code":["QR - Respiratory system","QR06 - Antihistamines for systemic use","QR06A - Antihistamines for systemic use","QR06AX - Other antihistamines for systemic use","QR06AX07 - Triprolidine","R - Respiratory system","R06 - Antihistamines for systemic use","R06A - Antihistamines for systemic use","R06AX - Other antihistamines for systemic use","R06AX07 - Triprolidine"],"Absorption, Distribution and Excretion":"Rapidly absorbed in the intestinal tract.","Aliases":["Triprolidin","Actidil","Tripolidina","Triprolidinum","Triprolidina","trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene","NCI-C61450","trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene","trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine","Dtxsid3023718","2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine","Dtxcid203718","Chebi:84116","Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, (E)-","(E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine","(E)-2-(3-(1-pyrrolidinyl)-1-p-toluenepropenyl)pyridine","2-((E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl)pyridine","2-((1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl)pyridine","R06AX07","207-627-0","Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-, (E)-","Histafed","CHEMBL855","Ncgc00024714-03","(E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine","HSDB 6316","Cas-486-12-4","CCRIS 7212","Einecs 207-627-0","Unii-2l8t9s52qm","(E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine","Prestwick2_000262","Prestwick3_000262","Spectrum5_001467","Schembl4905","Lopac0_001130","BSPBio_000104","BSPBio_002255","Bidd:gt0569","BPBio1_000116","GTPL1228","orb1689510","orb3024973","Schembl29631820","HMS2089M21","HY-B1808","Tox21_110919","Bdbm50292411","CCG-12422","EBC-26419","Akos027460758","Tox21_110919_1","DB00427","Sdccgsbi-0025383.p005","Idi1_000297","Ncgc00024714-02","Ncgc00024714-04","Ncgc00024714-05","Ncgc00024714-06","Ncgc00024714-07","Ncgc00024714-08","Ncgc00024714-11","Ncgc00024714-15","AS-87247","DA-78634","Bim-0025383.p001","Sbi-0025383.p004","CS-0013854","NS00008343","D08648","En300-755286","H55680","T60514","Ab00053563-02","Ab00053563-13","Ab00053563_14","L000901","2-(3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine","Brd-k11742128-003-05-1","Brd-k11742128-003-15-0","Brd-k11742128-003-22-6","Brd-k11742128-003-23-4","1-((E)-3-Pyridin-2-yl-3-p-tolyl-allyl)-pyrrolidinium","2-((E)-3-Pyrrolidin-1-yl-1-p-tolyl-propenyl)-pyridine","2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine","(E)-2-(3-(pyrrolidin-1-yl)-1-p-tolylprop-1-enyl)pyridine"],"Biological Half-Life":"4 to 6 hours.","CAS":"486-12-4","ChemicalClasses":["phenethylamine"],"Chirality":"achiral","Color/Form":"Crystals from light petroleum","Drug Classes":["Breast Feeding","Lactation","Milk, Human","Antihistamines"],"Drug Indication":"For the symptomatic relief of seasonal or perennial allergic rhinitis or nonallergic rhinitis; allergic conjunctivitis; and mild, uncomplicated allergic skin manifestations of urticaria and angioedema. Also used in combination with other agents for the symptomatic relief of symptoms associated with the common cold.","Drug Warnings":"Use is not recommended in newborn or premature infants because this age group has an increased susceptibility to anticholinergic side effects, such as central nervous system excitation, and an increased tendency toward convulsions. A paradoxical reaction characterized by hyperexcitability may occur in children taking antihistamines. /Antihistamines/","Erowid Experience Reports":[{"Author":"Malagai","Id":28647,"Title":"A Lot of Fun"}],"Esters":[],"European Community (EC) Number":"207-627-0","Formating":[],"HMDB ID":"HMDB0014571","HeavyAtomCount":21,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Antihistamines","IUPACName":"2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine","InChI":"InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+","InChIKey":"CBEQULMOCCWAQT-WOJGMQOQSA-N","Interactions":"Concurrent use /of ototoxic medications/ with antihistamines may mask the symptoms of ototoxicity such as tinnitus, dizziness, or vertigo. /Antihistamines/","KEGG Entries":[{"Id":"D01782","Interactions":[],"Synonyms":["Triprolidine hydrochloride","Triprolidine hydrochloride hydrate","Venen"]},{"Id":"D08648","Interactions":[],"Synonyms":["Triprolidine"]},{"Id":"D01782","Interactions":[],"Synonyms":["Triprolidine hydrochloride","Triprolidine hydrochloride hydrate","Venen"]},{"Id":"D08648","Interactions":[],"Synonyms":["Triprolidine"]}],"MeSH Headers":[{"Id":"M0022015","Link":"https://id.nlm.nih.gov/mesh/M0022015.html","Name":"Triprolidine","Ref":54},{"Id":"M0022016","Link":"https://id.nlm.nih.gov/mesh/M0022016.html","Name":"Actidil","Ref":56},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":57},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":80},{"Id":"M0010395","Link":"https://id.nlm.nih.gov/mesh/M0010395.html","Name":"Histamine H1 Antagonists","Ref":81},{"Id":"M0028295","Link":"https://id.nlm.nih.gov/mesh/M0028295.html","Name":"Anti-Allergic Agents","Ref":82}],"MeSH Pharmacological Classification":[{"Id":"M0010395","Link":"https://id.nlm.nih.gov/mesh/M0010395.html","Name":"Histamine H1 Antagonist","Ref":81},{"Id":"M0028295","Link":"https://id.nlm.nih.gov/mesh/M0028295.html","Name":"Anti-Allergic Agent","Ref":82}],"Mechanism of Action":"Triprolidine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.","Melting Point":"59-61 °C","Metabolism/Metabolites":"MAIN SITE OF METABOLIC TRANSFORMATION IS LIVER. /ANTIHISTAMINES/","MolecularFormula":"C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e22\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"278.4 g/mol","Pharmacodynamics":"In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Triprolidine, is a histamine H1 antagonist that competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies. Triprolidine has anticholinergic and sedative effects.","Physical Description":"Solid","PubChemId":5282443,"Record Description":["LiverTox|Respiratory|Allergy symptoms|Antihistamine"],"Records":{"UNII":{"Impurities":[]}},"RefChem":"56180","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Triprolidine","Name":"Triprolidine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q417654","Name":"Triprolidine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB00427","Name":"Triprolidine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5282443","Name":"Triprolidine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=486-12-4","Name":"Triprolidine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014571","Name":"Triprolidine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D08648","Name":"Triprolidine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/2L8T9S52QM","Name":"Triprolidine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3023718","Name":"Triprolidine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5282443, triprolidine. Accessed May 8, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5282443\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5282443\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Triprolidine. UNII: 2L8T9S52QM. Global Substance Registration System. Accessed May 8, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/2L8T9S52QM\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/2L8T9S52QM\u003c/a\u003e"],"SMILES":"CC1=CC=C(C=C1)/C(=C\\CN2CCCC2)/C3=CC=CC=N3","SaltData":[{"AcidCount":1,"Amine":"Triprolidine","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","RName":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 117.38 94.107\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h118v95H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m1.038 93.05 13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m14.232 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