{"ATC Code":"N - Nervous system","Abbreviation":[],"Aliases":["Tilidate","trans-Tilidine","20380-58-9","GY33N31E9Y","IDS-NT-003","3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, (1R,2S)-rel-","Go 1261","Godecke, Tilidin","RefChem:898119","Go1261","243-774-7","257-522-9","Dextilidine","Dextilidina","Dextilidinum","32447-90-8","Ethyl trans-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate","Ethyl trans-2-(dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylate","Tilidin","3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, trans-","Tilidine, (+)-","Tilidine, trans-(+)-","(1S,2R)-Ethyl-2-dimethylamino-1-phenyl-3-cyclohexen-1-carboxylat","DB13787","D08597"],"CAS":"51931-66-9","ChEBI":"CHEBI:77823","ChEMBL":"CHEMBL2104560","ChemicalClasses":["carboxylic acid"],"Chirality":"absolute","Classes":["Opioid"],"DEA no":9750,"EINECS":"243-774-7","Esters":[],"European Community (EC) Number":"257-522-9","Formating":[],"HeavyAtomCount":20,"IUPACName":"ethyl (1S,2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate","InChI":"InChI=1S/C17H23NO2/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3/h5-8,10-12,15H,4,9,13H2,1-3H3/t15-,17+/m1/s1","InChIKey":"WDEFBBTXULIOBB-WBVHZDCISA-N","MeSH Pharmacological Classification":"Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.","MolecularFormula":"C\u003csub\u003e17\u003c/sub\u003eH\u003csub\u003e23\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"273.37 g/mol","Opticalactivity":"( + )","PubChemId":30131,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Tilidine","Name":"Tilidine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q421108","Name":"Tilidine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB13787","Name":"Tilidine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/30131","Name":"Tilidine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104560","Name":"Tilidine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:77823","Name":"Tilidine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=51931-66-9","Name":"Tilidine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D08597","Name":"Tilidine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/2728MV084C","Name":"Tilidine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID9023671","Name":"Tilidine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 30131, Tilidine. Accessed September 1, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/30131\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/30131\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Tilidine. UNII: 2728MV084C. Global Substance Registration System. Accessed September 1, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/2728MV084C\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/2728MV084C\u003c/a\u003e"],"SMILES":"CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)C2=CC=CC=C2","SaltData":[],"Salts":[],"StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 73.012 92.833\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h74v93H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"M41.928.91v15.24M41.928 16.15l-9.92 5.727M28.73 27.691V39.01\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m28.73 39.01-9.92 5.727M26.291 37.602l-8.701 5.024\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m18.81 44.737 4.96-2.864M17.59 42.626l4.351-2.512\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m41.753 46.933.35-.606M39.407 45.916l.642-1.112M37.062 44.898l.933-1.616M34.716 43.881l1.225-2.122M32.371 42.864l1.516-2.628M30.025 41.846l1.809-3.132M27.679 40.829l2.101-3.638\"/\u003e\u003c/g\u003e\u003cpath d=\"m41.928 46.63 5.217-14.328M47.145 32.302l15.015-2.656M62.16 29.646l9.799 11.672\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m66.742 55.647 5.217-14.329M64.932 53.49l4.253-11.683\"/\u003e\u003c/g\u003e\u003cpath d=\"m66.742 55.647-15.016 2.655M41.928 46.63l9.798 11.672\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"m52.055 58.422-.658-.239-5.05 10.116 1.541.561 1.542.56z\" class=\"bond\"/\u003e\u003cpath d=\"m49.36 76.009 6.96 8.287M43.178 72.627l-11.899.004\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"m42.196 46.855-.536-.45-18.284 18.934 2.488.439.865 2.374z\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m31.086 80.105-5.222-14.327M28.312 79.616l-4.257-11.681\"/\u003e\u003c/g\u003e\u003cpath d=\"M31.086 80.105 21.291 91.78\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m6.275 89.129 15.016 2.651M8.084 86.972l12.244 2.162\"/\u003e\u003c/g\u003e\u003cpath d=\"M6.275 89.129 1.053 74.802\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M10.848 63.127 1.053 74.802M11.811 65.773l-7.985 9.518\"/\u003e\u003c/g\u003e\u003cpath d=\"m25.864 65.778-15.016-2.651\" class=\"bond\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M30.989 23.767q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.757 0-1.263-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.733 0 1.233.315.5.31.756.876.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.529 1.221.529.839 0 1.22-.529.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M17.181 45.571q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.245-.572-.245-1.334 0-.75.245-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M48.46 75.075h-.72l-2.62-4.066h-.029l.029.595q.024.358.024.733v2.738h-.565v-4.899h.714L47.9 74.23h.03l-.018-.328q-.012-.22-.023-.476-.006-.262-.006-.482v-2.768h.577z\" class=\"atom\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m32.008 21.877 4.96-2.863M28.73 27.691v5.659\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m49.36 76.009 3.48 4.144M43.178 72.627l-5.95.002\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":{"Cognitive Effects":["Cognitive euphoria","Thought deceleration","Anxiety suppression","Compulsive redosing","Increased music appreciation"],"Physical Effects":["Respiratory depression","Pain relief","Itchiness","Constipation","Cough suppression","Sedation","Nausea","Pupil constriction","Stomach cramp","Difficulty urinating"],"Visual Effects":["Double vision"]},"Title":"Tilidine","UNII":"2728MV084C","Wikidata":"Q421108","Wikipedia":"Tilidine","XLogP":3.1}