{"Abbreviation":[],"Aliases":["Tiletamina","Cyclohexanone, 2-(ethylamino)-2-(2-thienyl)-","2-(Ethylamino)-2-(2-thienyl)cyclohexanone","Tiletaminum","2-(Ethylamino)-2-(thiophen-2-yl)cyclohexan-1-one","238-031-9","Prestwick0_001022","Prestwick1_001022","Prestwick2_001022","Prestwick3_001022","BSPBio_001203","SPBio_003064","BPBio1_001325","DB11549","Ncgc00179264-01","Ncgc00179264-03","DA-10477","AB00514642","2-(Ethylamino)-2-(2-thienyl)cyclohexanone #","D08596","2-(ethylamino)-2-thiophen-2-yl-1-cyclohexanone","Ab00514642_02","2-(ethylamino)-2-thiophen-2-yl-cyclohexan-1-one","A807808","Q2083144"],"CAS":"14176-49-9","ChEBI":"CHEBI:94356","ChEMBL":"CHEMBL2110703","ChemicalClasses":[],"Chirality":"racemic","Classes":["N-Methyl-D-aspartic acid receptor antagonist"],"Drug Warnings":"Two commonly used anesthetic combinations, ketamine acepromazine and tiletamine-zolazepam, were compared to identify their effects upon body temperature in cynomolgus macaques. 30 cynomolgus macaques previously implanted with subcutaneous telemetry devices /were allocated/ into two groups of 15 animals. Baseline temperature data were collected for 3 days before administering anesthesia to establish normal diurnal temperature patterns for each monkey. Each group then was anesthetized with either ketamine-acepromazine or tiletamine-zolazepam, and their body temperatures were recorded at 15-min intervals. Both groups had marked decreases in body temperature, with the greatest decreases in the tiletamine-zolazepam group. In addition, both groups had notable post-anesthesia elevations in body temperature that often lasted for more than 24 hr postinduction.","EINECS":"238-031-9","Erowid Experience Reports":[{"Author":"Toad","Id":"10352","Title":"Trick or Treat?"},{"Author":"LimbuBonda","Id":"114809","Title":"Successes in War Chemistry"},{"Author":"Mr. Crowley","Id":"115200","Title":"The Strangest Trip I've Ever Had"},{"Author":"Nihto","Id":"115304","Title":"Soft and Senseless"},{"Author":"Etazhi","Id":"115933","Title":"Oh Boy Did It Impress Me"},{"Author":"Gavin","Id":"5696","Title":"3 Months of Complete Dissociation"},{"Author":"p0ly","Id":"87288","Title":"Disgusting Dissociative"}],"Esters":[],"European Community (EC) Number":"238-031-9","Formating":[],"HMDB ID":"HMDB0259091","HeavyAtomCount":15,"IUPACName":"2-(ethylamino)-2-thiophen-2-ylcyclohexan-1-one","InChI":"InChI=1S/C12H17NOS/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14/h5,7,9,13H,2-4,6,8H2,1H3","InChIKey":"QAXBVGVYDCAVLV-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman\u0026apos;s The Pharmacological Basis of Therapeutics, 8th ed) (See all compounds classified as Anesthetics, Dissociative.)","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eNOS","MolecularWeight":"223.34 g/mol","PubChemId":26533,"RefCount":2,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Tiletamine","Name":"Tiletamine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB11549","Name":"Tiletamine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/26533","Name":"Tiletamine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2110703","Name":"Tiletamine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:94356","Name":"Tiletamine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=14176-49-9","Name":"Tiletamine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0259091","Name":"Tiletamine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D08596","Name":"Tiletamine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/2YFC543249","Name":"Tiletamine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID5048552","Name":"Tiletamine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 26533, Tiletamine. Accessed July 27, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/26533\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/26533\u003c/a\u003e"],"SMILES":"CCNC1(CCCCC1=O)C2=CC=CS2","SaltData":[],"Salts":[],"StereoisomerData":[{"Aliases":null,"PubChemId":null,"SMILES":"CCN[C@@]1(c2cccs2)CCCCC1=O","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 66.453 67.469\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h67v68H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m13.079 1.051 11.997 9.399M25.076 10.45l-1.597 11.253\" class=\"bond\"/\u003e\u003cpath fill=\"#000\" stroke=\"none\" d=\"m34.716 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stroke=\"#ff0d0d\" d=\"m38.754 58.417 2.823-5.297M36.603 57.27l2.822-5.297\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M24.876 27.989h-.721l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.714l2.608 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.578zM20.432 27.989h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath fill=\"#c6c62c\" stroke=\"none\" d=\"M26.735 61.375q0 .649-.477 1.018-.47.363-1.268.363-.416 0-.768-.065-.345-.06-.577-.173v-.589q.244.113.607.202.369.09.762.09.548 0 .828-.215.279-.214.279-.577 0-.238-.107-.399-.101-.167-.351-.31-.25-.142-.697-.297-.625-.226-.946-.554-.316-.333-.316-.899 0-.393.197-.666.202-.28.553-.429.358-.155.816-.155.405 0 .738.078.34.071.613.196l-.196.53q-.25-.113-.548-.185-.297-.077-.625-.077-.458 0-.69.196-.233.197-.233.518 0 .244.102.411.107.167.339.298.232.125.631.279.429.155.726.34.298.178.453.434.155.25.155.637\" 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21.484l15.239-.52M57.349 20.964l8.062 12.934M65.411 33.898l-7.178 13.453M58.233 47.351l-15.24.52M34.932 34.938l8.061 12.933\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m44.4 47.823-5.646 10.594M42.248 46.676 36.603 57.27\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m38.754 58.417 2.823-5.297M36.603 57.27l2.822-5.297\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"M34.932 34.938 23.594 45.121\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m23.594 45.121-14.92-3.217M21.354 47.133l-11.456-2.47\"/\u003e\u003c/g\u003e\u003cpath d=\"m8.674 41.904-7.62 13.199\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M1.054 55.103 11.3 66.414M4.055 54.783l7.867 8.686\"/\u003e\u003c/g\u003e\u003cpath d=\"m11.3 66.414 11.083-4.928M23.594 45.121l1.183 11.207\" class=\"bond\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M24.876 27.989h-.721l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.714l2.608 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.738.078.34.071.613.196l-.196.53q-.25-.113-.548-.185-.297-.077-.625-.077-.458 0-.69.196-.233.197-.233.518 0 .244.102.411.107.167.339.298.232.125.631.279.429.155.726.34.298.178.453.434.155.25.155.637\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m23.479 21.703.798-5.627M23.479 21.703l.798-5.627M25.978 27.923l4.477 3.508M25.978 27.923l4.477 3.508\" class=\"hi\"/\u003e\u003cpath stroke=\"#c6c62c\" d=\"m22.383 61.486-5.542 2.464M24.777 56.328l-.591-5.603\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Therapeutic Uses":"/VET/ This study is the first to compare the anesthetic effects of two cyclohexamines on free-ranging subantarctic fur seal (Arctocephalus tropicalis) females. From April to July 1999, 107 females were immobilized for tooth extraction and blood sampling, using either ketamine (Ketalar, n = 58) alone or tiletamine-zolazepam (Zoletil 100, n = 49) mixture. Animals were injected intramuscularly at mean doses of 2.1 mg/kg for ketamine and 1.1 mg/kg for tiletamine-zolazepam mixture. Individual response to both drugs was highly variable. The dosage required to achieve a satisfactory level of anesthesia was smaller for subantarctic fur seals than for most other species of seals and was less for animals in better body condition. Few side effects were observed during the trials, aside from mild tremors caused by ketamine, and respiratory depression or prolonged apnea caused by tiletamine-zolazepam. ...","Title":"Tiletamine","UNII":"2YFC543249","Wikipedia":"Tiletamine","XLogP":2}