{"ATC Code":"R - Respiratory system","Abbreviation":"","Aliases":["3,7-Dimethylxanthine","Diurobromine","Theosalvose","Santheose","Teobromin","Theostene","Thesodate","Thesal","3,7-Dimethyl-3,7-dihydro-1H-purine-2,6-dione","Theobromin"],"Biological Half-Life":"The mean half-time of theobromine in human serum ranged from 6.1 to 10 hr.","Boiling Point":"Sublimes at 554-563 °F (NTP, 1992)","CAS":"83-67-0","ChEBI":"CHEBI:28946","ChEMBL":"CHEMBL1114","ChemicalClasses":["xanthine"],"Chirality":"achiral","Classes":null,"Color/Form":"Monoclinic needles (/crystalline structure is/ lamellar twining on 001 /axis/) from water","Decomposition":"Hazardous decomposition products formed under fire conditions - Carbon oxides, nitrogen oxides (NOx).","Density":"1.522 g/cu cm at 20 °C; relative density: 1.522 at 20 °C g/cm\u003csup\u003e3\u003c/sup\u003e","Dosing Info":[],"Drug Indication":"theobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension.","DrugClasses":["stimulant"],"EINECS":"201-494-2","EliminationHalfLife":"6–8 hours","European Community (EC) Number":"201-494-2","HMDB ID":"HMDB0002825","HeavyAtomCount":13,"Human Drugs":"Pharmaceuticals","IUPACName":"3,7-dimethylpurine-2,6-dione","InChI":"InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)9-7(13)11(5)2/h3H,1-2H3,(H,9,12,13)","InChIKey":"YAPQBXQYLJRXSA-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)","Melting Point":"675 °","MolecularFormula":"C\u003csub\u003e7\u003c/sub\u003eH\u003csub\u003e8\u003c/sub\u003eN\u003csub\u003e4\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"180.16 g/mol","Pharmacodynamics":"Theobromine, a xanthine derivative like caffeine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity).","Physical Description":"Theobromine is an odorless white crystalline powder. Bitter taste. pH (saturated solution in water): 5.5-7. (NTP, 1992)","PrevSalts":[],"PubChemId":5429,"Record Description":["Theobromine is an odorless white crystalline powder. Bitter taste. pH (saturated solution in water): 5.5-7. (NTP, 1992)","Theobromine is a dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator. It has a role as an adenosine receptor antagonist, a food component, a plant metabolite, a human blood serum metabolite, a mouse metabolite, a vasodilator agent and a bronchodilator agent.","Theobromine (3,7-dimethylxanthine) is the principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)","Theobromine has been reported in Camellia sinensis, Ilex perado, and other organisms with data available.","THEOBROMINE is a small molecule drug with a maximum clinical trial phase of III (across all indications) and has 3 investigational indications.","3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)","See also: Paullinia cupana seed (part of).","Theobromine is a dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator. It has a role as an adenosine receptor antagonist, a food component, a plant metabolite, a human blood serum metabolite, a mouse metabolite, a vasodilator agent and a bronchodilator agent."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Theobromine","Name":"Theobromine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q206844","Name":"Theobromine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01412","Name":"Theobromine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5429","Name":"Theobromine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1114","Name":"Theobromine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28946","Name":"Theobromine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=83-67-0","Name":"Theobromine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0002825","Name":"Theobromine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07480","Name":"Theobromine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/OBD445WZ5P","Name":"Theobromine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132","Name":"Theobromine","Sub":false}]}],"SMILES":"CN1C=NC2=C1C(=O)NC(=O)N2C","Scheduling":[],"Solubility":"less than 1 mg/mL at 64 °F (NTP, 1992)","Stability/Shelf Life":"Stable under recommended storage conditions.","StoreUNII":["OBD445WZ5P"],"StructureBase64":"<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" height="64.951mm" version="1.2" viewBox="0 0 66.951 64.951" width="66.951mm">
      
    <desc>Generated by the Chemistry Development Kit (http://github.com/cdk)</desc>
      
    <g fill="#3050F8" stroke="#000000" stroke-linecap="round" stroke-linejoin="round" stroke-width=".7">
            
        <rect fill="#FFFFFF" height="65.0" stroke="none" width="67.0" x=".0" y=".0"/>
            
        <g class="mol" id="mol1">
                  
            <line class="bond" id="mol1bnd1" x1="61.688" x2="58.195" y1="6.779" y2="17.487"/>
                  
            <line class="bond" id="mol1bnd2" x1="59.566" x2="65.902" y1="24.85" y2="33.561"/>
                  
            <g class="bond" id="mol1bnd3">
                        
                <line x1="59.566" x2="65.902" y1="42.273" y2="33.561"/>
                        
                <line x1="57.594" x2="62.887" y1="40.838" y2="33.561"/>
                      
                <line class="hi" stroke="#3050F8" x1="59.566" x2="62.734" y1="42.273" y2="37.917"/>
                <line class="hi" stroke="#3050F8" x1="57.594" x2="60.2405" y1="40.838" y2="37.1995"/>
            </g>
                  
            <line class="bond" id="mol1bnd4" x1="53.687" x2="42.432" y1="44.802" y2="41.181"/>
                  
            <g class="bond" id="mol1bnd5">
                        
                <line x1="42.432" x2="42.432" y1="41.181" y2="25.941"/>
                        
                <line x1="39.994" x2="39.994" y1="39.773" y2="27.349"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd6" x1="53.687" x2="42.432" y1="22.321" y2="25.941"/>
                  
            <line class="bond" id="mol1bnd7" x1="42.432" x2="29.224" y1="25.941" y2="18.321"/>
                  
            <g class="bond" id="mol1bnd8">
                        
                <line x1="28.005" x2="28.005" y1="19.025" y2="7.002"/>
                        
                <line x1="30.443" x2="30.443" y1="19.025" y2="7.002"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="28.005" x2="28.005" y1="7.001999999999999" y2="13.013499999999999"/>
                <line class="hi" stroke="#FF0D0D" x1="30.443" x2="30.443" y1="7.001999999999999" y2="13.013499999999999"/>
            </g>
                  
            <line class="bond" id="mol1bnd9" x1="29.224" x2="19.17" y1="18.321" y2="24.122"/>
                  
            <line class="bond" id="mol1bnd10" x1="16.016" x2="16.016" y1="29.791" y2="41.181"/>
                  
            <g class="bond" id="mol1bnd11">
                        
                <line x1="17.236" x2="6.707" y1="41.885" y2="47.966"/>
                        
                <line x1="16.016" x2="5.487" y1="39.773" y2="45.854"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="6.707000000000001" x2="11.9715" y1="47.966" y2="44.9255"/>
                <line class="hi" stroke="#FF0D0D" x1="5.487" x2="10.7515" y1="45.854" y2="42.813500000000005"/>
            </g>
                  
            <line class="bond" id="mol1bnd12" x1="16.016" x2="26.071" y1="41.181" y2="46.982"/>
                  
            <line class="bond" id="mol1bnd13" x1="42.432" x2="32.378" y1="41.181" y2="46.982"/>
                  
            <line class="bond" id="mol1bnd14" x1="29.224" x2="29.224" y1="52.651" y2="64.041"/>
                  
            <path class="atom" d="M58.902 23.717h-.721l-2.619 -4.066h-.03q.012 .238 .03 .596q.024 .357 .024 .732v2.738h-.566v-4.899h.715l2.607 4.054h.03q-.006 -.107 -.018 -.328q-.012 -.22 -.024 -.476q-.006 -.262 -.006 -.482v-2.768h.578v4.899z" id="mol1atm2" stroke="none"/>
                  
            <path class="atom" d="M58.902 48.304h-.721l-2.619 -4.066h-.03q.012 .239 .03 .596q.024 .357 .024 .732v2.738h-.566v-4.899h.715l2.607 4.054h.03q-.006 -.107 -.018 -.327q-.012 -.221 -.024 -.477q-.006 -.261 -.006 -.482v-2.768h.578v4.899z" id="mol1atm4" stroke="none"/>
                  
            <path class="atom" d="M31.483 3.078q.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 -.0 1.232 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM27.62 3.078q-.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" fill="#FF0D0D" id="mol1atm8" stroke="none"/>
                  
            <g class="atom" id="mol1atm9">
                        
                <path d="M17.957 28.391h-.72l-2.62 -4.066h-.03q.012 .238 .03 .595q.024 .357 .024 .732v2.739h-.566v-4.9h.715l2.607 4.055h.03q-.006 -.108 -.018 -.328q-.012 -.22 -.024 -.476q-.006 -.262 -.006 -.482v-2.769h.578v4.9z" stroke="none"/>
                        
                <path d="M13.514 28.391h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619v4.9z" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M5.078 48.8q.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM1.215 48.8q-.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.928 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .524 -.393 1.452z" fill="#FF0D0D" id="mol1atm11" stroke="none"/>
                  
            <path class="atom" d="M31.165 51.251h-.72l-2.62 -4.066h-.03q.012 .238 .03 .595q.024 .357 .024 .732v2.739h-.566v-4.9h.715l2.607 4.055h.03q-.006 -.108 -.018 -.328q-.012 -.22 -.024 -.476q-.006 -.262 -.006 -.482v-2.769h.578v4.9z" id="mol1atm12" stroke="none"/>
                
            <line class="hi" id="mol1bnd1" stroke="#3050F8" x1="58.195" x2="59.941500000000005" y1="17.487" y2="12.133"/>
            <line class="hi" id="mol1bnd2" stroke="#3050F8" x1="59.566" x2="62.734" y1="24.85" y2="29.2055"/>
            <line class="hi" id="mol1bnd4" stroke="#3050F8" x1="53.687" x2="48.0595" y1="44.802" y2="42.9915"/>
            <line class="hi" id="mol1bnd6" stroke="#3050F8" x1="53.687" x2="48.0595" y1="22.321" y2="24.131"/>
            <line class="hi" id="mol1bnd9" stroke="#3050F8" x1="19.17" x2="24.197000000000003" y1="24.122" y2="21.2215"/>
            <line class="hi" id="mol1bnd9" stroke="#3050F8" x1="19.17" x2="24.197000000000003" y1="24.122" y2="21.2215"/>
            <line class="hi" id="mol1bnd10" stroke="#3050F8" x1="16.016" x2="16.016" y1="29.791" y2="35.486"/>
            <line class="hi" id="mol1bnd10" stroke="#3050F8" x1="16.016" x2="16.016" y1="29.791" y2="35.486"/>
            <line class="hi" id="mol1bnd12" stroke="#3050F8" x1="26.071" x2="21.0435" y1="46.982" y2="44.0815"/>
            <line class="hi" id="mol1bnd13" stroke="#3050F8" x1="32.378" x2="37.405" y1="46.982" y2="44.0815"/>
            <line class="hi" id="mol1bnd14" stroke="#3050F8" x1="29.224" x2="29.224" y1="52.651" y2="58.346000000000004"/>
        </g>
          
    </g>
    
</svg>
","Taste":"Bitter tasting alkaloid","Therapeutic Uses":"Diuretic, bronchodilator, cardiotonic. /Former use/","Title":"Theobromine","UNII":"OBD445WZ5P","Wikidata":"Q206844","Wikipedia":"Theobromine","XLogP":-0.8}