{"Abbreviation":"","Aliases":["1,1,1,2-Tetrafluoroethane","Norflurane","HFC-134a","1,2,2,2-Tetrafluoroethane","Refrigerant R134a","HFA 134a","R-134a","Norflurano","Ethane, 1,1,1,2-tetrafluoro-","HFA-134a"],"Biological Half-Life":"... Ten male volunteers were exposed to 500 ppm HFC-134a (2 hr, 50 W exercise). ... The post-exposure urinary excretion was 0.002% of the inhaled amount, and the half-time was 58 min (pooled data). ... The late decay in blood was consistent with a wash-out of HFC-134a from fat tissues, with a half-time of 114+/-21 min. ...","Boiling Point":"-26.5 °C at 1 atmosphere","CAS":"811-97-2","ChEMBL":"CHEMBL2104432","ChemicalClasses":[],"Chirality":"achiral","Classes":null,"Color/Form":"Colorless gas","Decomposition":"When heated to decomposition it emits toxic vapors of /flouride/.","Density":"1.2072 g/cu cm at 25 °C g/cm\u003csup\u003e3\u003c/sup\u003e","Dosing Info":[],"DrugClasses":[],"EINECS":"212-377-0","European Community (EC) Number":"212-377-0","HMDB ID":"HMDB0244035","HeavyAtomCount":6,"IUPACName":"1,1,1,2-tetrafluoroethane","InChI":"InChI=1S/C2H2F4/c3-1-2(4,5)6/h1H2","InChIKey":"LVGUZGTVOIAKKC-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Compressed gases or vapors in a container which, upon release of pressure and expansion through a valve, carry another substance from the container. They are used for cosmetics, household cleaners, and so on. Examples are BUTANES; CARBON DIOXIDE; FLUOROCARBONS; NITROGEN; and PROPANE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (See all compounds classified as Aerosol Propellants.)","Melting Point":"-103.296 °C","MolecularFormula":"C\u003csub\u003e2\u003c/sub\u003eH\u003csub\u003e2\u003c/sub\u003eF\u003csub\u003e4\u003c/sub\u003e","MolecularWeight":"102.03 g/mol","Odor":"Faint ethereal odor","Physical Description":"1,1,1,2-tetrafluoroethane appears as a colorless gas with a slight ethereal odor. Vapors are heavier than air. Shipped liquefied under own vapor pressure. Flash point 351 °F. Inhalation at high concentrations is harmful and may cause heart irregularities, unconsciousness or death without warning. Liquid contact may cause frostbite. Vapors can replace the available oxygen.","PrevSalts":[],"PubChemId":13129,"Record Description":["1,1,1,2-tetrafluoroethane appears as a colorless gas with a slight ethereal odor. Vapors are heavier than air. Shipped liquefied under own vapor pressure. Flash point 351 °F. Inhalation at high concentrations is harmful and may cause heart irregularities, unconsciousness or death without warning. Liquid contact may cause frostbite. Vapors can replace the available oxygen.","Norflurane is under investigation in clinical trial NCT01673061 (Vapocoolant Spray for Numbing Small Boils Before Incision and Drainage).","NORFLURANE is a small molecule drug with a maximum clinical trial phase of II.","1,1,1,2-tetrafluoroethane, R-134a, Forane 134a, Genetron 134a, Florasol 134a, Suva 134a or HFC-134a, also known as norflurane (INN), is a haloalkane refrigerant with thermodynamic properties similar to R-12 (dichlorodifluoromethane) but with insignificant ozone depletion potential. It has the formula CH2FCF3 and a boiling point of \u0026#8722;26.3 ?C (\u0026#8722;15.34 ?F) at atmospheric pressure. R-134a cylinders are colored light blue.[2] Attempts at phasing out its use as a refrigerant with substances that have lower global warming potentials, such as HFO-1234yf are underway."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/1,1,1,2-Tetrafluoroethane","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q423029","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB13116","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/13129","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2104432","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=811-97-2","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0244035","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D05208","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/DH9E53K1Y8","Name":"Tetrafluoroethane","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021324","Name":"Tetrafluoroethane","Sub":false}]}],"SMILES":"C(C(F)(F)F)F","Solubility":"Insoluble in water","Stability/Shelf Life":"Stable under recommended storage conditions.","StoreUNII":["DH9E53K1Y8"],"StructureBase64":"PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHhtbG5zOnhsaW5rPSJodHRwOi8vd3d3LnczLm9yZy8xOTk5L3hsaW5rIiBoZWlnaHQ9IjM2LjQ5OW1tIiB2ZXJzaW9uPSIxLjIiIHZpZXdCb3g9IjAgMCA0MS45NTIgMzYuNDk5IiB3aWR0aD0iNDEuOTUybW0iPgogICAgICAKICAgIDxkZXNjPkdlbmVyYXRlZCBieSB0aGUgQ2hlbWlzdHJ5IERldmVsb3BtZW50IEtpdCAoaHR0cDovL2dpdGh1Yi5jb20vY2RrKTwvZGVzYz4KICAgICAgCiAgICA8ZyBmaWxsPSIjOTBFMDUwIiBzdHJva2U9IiMwMDAwMDAiIHN0cm9rZS1saW5lY2FwPSJyb3VuZCIgc3Ryb2tlLWxpbmVqb2luPSJyb3VuZCIgc3Ryb2tlLXdpZHRoPSIuNyI+CiAgICAgICAgICAgIAogICAgICAgIDxyZWN0IGZpbGw9IiNGRkZGRkYiIGhlaWdodD0iMzcuMCIgc3Ryb2tlPSJub25lIiB3aWR0aD0iNDIuMCIgeD0iLjAiIHk9Ii4wIi8+CiAgICAgICAgICAgIAogICAgICAgIDxnIGNsYXNzPSJtb2wiIGlkPSJtb2wxIj4KICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJib25kIiBpZD0ibW9sMWJuZDEiIHgxPSIzMi40MDYiIHgyPSIxNy4xNjYiIHkxPSIxOC4yNSIgeTI9IjE4LjI1Ii8+CiAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICA8bGluZSBjbGFzcz0iYm9uZCIgaWQ9Im1vbDFibmQyIiB4MT0iMTcuMTY2IiB4Mj0iMTcuMTY2IiB5MT0iMTguMjUiIHkyPSIyOS42NCIvPgogICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgPGxpbmUgY2xhc3M9ImJvbmQiIGlkPSJtb2wxYm5kMyIgeDE9IjE3LjE2NiIgeDI9IjE3LjE2NiIgeTE9IjE4LjI1IiB5Mj0iNi4wNzUiLz4KICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJib25kIiBpZD0ibW9sMWJuZDQiIHgxPSIxNy4xNjYiIHgyPSI0LjU4OCIgeTE9IjE4LjI1IiB5Mj0iMTguMjUiLz4KICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJib25kIiBpZD0ibW9sMWJuZDUiIHgxPSIzMi40MDYiIHgyPSIzNy45NiIgeTE9IjE4LjI1IiB5Mj0iOC42MyIvPgogICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgPHBhdGggY2xhc3M9ImF0b20iIGQ9Ik0xNi40MTMgMzUuOTM5aC0uNjEzdi00Ljg5OWgyLjczMnYuNTQyaC0yLjExOXYxLjczOGgxLjk5NHYuNTQyaC0xLjk5NHYyLjA3N3oiIGlkPSJtb2wxYXRtMyIgc3Ryb2tlPSJub25lIi8+CiAgICAgICAgICAgICAgICAgIAogICAgICAgICAgICA8cGF0aCBjbGFzcz0iYXRvbSIgZD0iTTE2LjQxMyA1LjQ1OWgtLjYxM3YtNC44OTloMi43MzJ2LjU0MmgtMi4xMTl2MS43MzhoMS45OTR2LjU0MmgtMS45OTR2Mi4wNzd6IiBpZD0ibW9sMWF0bTQiIHN0cm9rZT0ibm9uZSIvPgogICAgICAgICAgICAgICAgICAKICAgICAgICAgICAgPHBhdGggY2xhc3M9ImF0b20iIGQ9Ik0xLjE3MyAyMC42OTloLS42MTN2LTQuODk5aDIuNzMydi41NDJoLTIuMTE5djEuNzM4aDEuOTk0di41NDJoLTEuOTk0djIuMDc3eiIgaWQ9Im1vbDFhdG01IiBzdHJva2U9Im5vbmUiLz4KICAgICAgICAgICAgICAgICAgCiAgICAgICAgICAgIDxwYXRoIGNsYXNzPSJhdG9tIiBkPSJNMzkuMjczIDcuNTAxaC0uNjEzdi00Ljg5OWgyLjczMnYuNTQyaC0yLjExOXYxLjczOGgxLjk5NHYuNTQyaC0xLjk5NHYyLjA3N3oiIGlkPSJtb2wxYXRtNiIgc3Ryb2tlPSJub25lIi8+CiAgICAgICAgICAgICAgICAKICAgICAgICAgICAgPGxpbmUgY2xhc3M9ImhpIiBpZD0ibW9sMWJuZDIiIHN0cm9rZT0iIzkwRTA1MCIgeDE9IjE3LjE2NiIgeDI9IjE3LjE2NiIgeTE9IjI5LjY0IiB5Mj0iMjMuOTQ1Ii8+CiAgICAgICAgICAgIDxsaW5lIGNsYXNzPSJoaSIgaWQ9Im1vbDFibmQzIiBzdHJva2U9IiM5MEUwNTAiIHgxPSIxNy4xNjYiIHgyPSIxNy4xNjYiIHkxPSI2LjA3NDk5OTk5OTk5OTk5OSIgeTI9IjEyLjE2MjUiLz4KICAgICAgICAgICAgPGxpbmUgY2xhc3M9ImhpIiBpZD0ibW9sMWJuZDQiIHN0cm9rZT0iIzkwRTA1MCIgeDE9IjQuNTg4MDAwMDAwMDAwMDAxIiB4Mj0iMTAuODc3IiB5MT0iMTguMjUiIHkyPSIxOC4yNSIvPgogICAgICAgICAgICA8bGluZSBjbGFzcz0iaGkiIGlkPSJtb2wxYm5kNSIgc3Ryb2tlPSIjOTBFMDUwIiB4MT0iMzcuOTYiIHgyPSIzNS4xODMiIHkxPSI4LjYzIiB5Mj0iMTMuNDQwMDAwMDAwMDAwMDAxIi8+CiAgICAgICAgPC9nPgogICAgICAgICAgCiAgICA8L2c+CiAgICAKPC9zdmc+Cg==","Therapeutic Uses":"/CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. 1,1,1,2-Tetrafluoroethane is included in the database.","Title":"Tetrafluoroethane","UNII":"DH9E53K1Y8","Wikidata":"Q423029","Wikipedia":"1,1,1,2-Tetrafluoroethane","XLogP":1.7}