{"ATC Code":"N - Nervous system","Abbreviation":[],"Aliases":["Mebicar","mebikar","Tetramethylglycoluril","Tetrahydro-1,3,4,6-tetramethylimidazo(4,5-d)imidazole-2,5(1H,3H)-dione","imidazo[4,5-d]imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetramethyl-","Glycoluril, 1,3,4,6-tetramethyl-","2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo-(3.3.0)-octan-3,7-dione","Imidazo(4,5-d)imidazole-2,5(1H,3H)-dione, tetrahydro-1,3,4,6-tetramethyl-","RefChem:810813","(3as,6as)-1,3,4,6-tetramethyl-octahydro-(1,3)diazolo(4,5-d)imidazole-2,5-dione","1,3,4,6-Tetramethyltetrahydroimidazo[4,5-d]imidazole-2,5(1H,3H)-dione","2,4,6,8-Tetraazabicyclo[3.3.0]octane-3,7-dione, 2,4,6,8-tetramethyl-","1,3,4,6-tetramethyl-octahydro-[1,3]diazolo[4,5-d]imidazole-2,5-dione","1,3,4,6-tetramethyl-1,3,4,6,3a,6a-hexahydro-1,3,4,6-tetraazapentalene-2,5-dion e","Temgicoluril?","1,3,4,6-Tetramethyltetrahydroimidazo[4,5-d]-imidazole-2,5(1H,3H)-dione","AC1Q6FJD","2,4,6,8-Tetramethyl-2,4,6,8-tetraazobicyclo(3.3.0)octane-3,7-dione","ChemDiv1_025094","Aronis020697","orb1298102","HMS658E14","Xiuusfjtjxfngh-uhfffaoysa-","Albb-014894","2,4,6,8-Tetramethyl-2,4,6,8-tetraazobizykl(3,3,0)oktandion-3,7"],"CAS":"10095-06-4","ChEBI":"CHEBI:136038","ChEMBL":"CHEMBL3707390","ChemicalClasses":["cycloalkylamine"],"Chirality":"achiral","DurationOfAction":"","EliminationHalfLife":"3 hours{-{cite patent | country = US | number = 20110070305 | inventor = Schwarz J, Weisspapir M | title = Sustained release pharmaceutical composition containing mebicar|url=https://www.google.com/patents/US20110070305 | assign1 = Alpharx Inc. | pubdate = 2011 – 03-24 }-}","Esters":[],"European Community (EC) Number":"682-123-5","Formating":[],"HeavyAtomCount":14,"IUPACName":"1,3,4,6-tetramethyl-3a,6a-dihydroimidazo[4,5-d]imidazole-2,5-dione","InChI":"InChI=1S/C8H14N4O2/c1-9-5-6(11(3)7(9)13)12(4)8(14)10(5)2/h5-6H,1-4H3","InChIKey":"XIUUSFJTJXFNGH-UHFFFAOYSA-N","LD50":[{"dosages":[{"amount":"3450 mg/kg","route":"intraperitoneal"}],"organism":"Rat"},{"dosages":[{"amount":"3800 mg/kg","route":"intraperitoneal"}],"organism":"Mouse"}],"MeSH Pharmacological Classification":"Compounds capable of relieving pain without the loss of CONSCIOUSNESS.","MolecularFormula":"C\u003csub\u003e8\u003c/sub\u003eH\u003csub\u003e14\u003c/sub\u003eN\u003csub\u003e4\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"198.22 g/mol","Opticalactivity":"UNSPECIFIED","PubChemId":122282,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Temgicoluril","Name":"Temgicoluril","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q4286560","Name":"Temgicoluril","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB13522","Name":"Temgicoluril","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/122282","Name":"Temgicoluril","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL3707390","Name":"Temgicoluril","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:136038","Name":"Temgicoluril","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=10095-06-4","Name":"Temgicoluril","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D10508","Name":"Temgicoluril","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/55FE6NPG89","Name":"Temgicoluril","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID60143588","Name":"Temgicoluril","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 122282, Temgicoluril. Accessed October 5, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/122282\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/122282\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Temgicoluril. UNII: 55FE6NPG89. Global Substance Registration System. Accessed October 5, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/55FE6NPG89\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/55FE6NPG89\u003c/a\u003e"],"SMILES":"CN1C2C(N(C1=O)C)N(C(=O)N2C)C","SaltData":[],"Salts":[],"Scheduling":[{"gov":"United States","ref":[],"schedule":"Unscheduled; not FDA approved substance"}],"StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 83.058 55.567\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h84v56H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m22.273 54.565 3.493-10.707M30.274 39.024l11.255-3.621M41.529 35.403v-15.24M41.529 20.163l-11.255-3.62M24.395 19.072l-6.336 8.711M24.395 36.495l-6.336-8.712\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M18.946 29.002H6.479M18.946 26.564H6.479\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M6.479 29.002h6.234M6.479 26.564h6.234\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"M25.766 11.709 22.273 1.001M41.529 20.163l11.255-3.62M58.663 19.072l6.335 8.711\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M64.112 26.564h12.467M64.112 29.002h12.467\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M76.579 26.564h-6.234M76.579 29.002h-6.234\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m64.998 27.783-6.335 8.712M41.529 35.403l11.255 3.621M57.291 43.858l3.494 10.707M57.291 11.709l3.494-10.708\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M28.941 42.527h-.721l-2.619-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.715l2.607 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.578zM28.941 17.939h-.721l-2.619-4.066h-.03l.03.596q.024.357.024.732v2.738h-.566V13.04h.715l2.607 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482V13.04h.578z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M5.078 27.78q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887Q.56 28.53.56 27.768q0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M57.998 17.939h-.72l-2.619-4.066h-.03l.03.596q.023.357.023.732v2.738h-.565V13.04h.714l2.608 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482V13.04h.577z\" class=\"atom\"/\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M82.498 27.78q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.452\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M57.998 42.527h-.72l-2.619-4.066h-.03l.03.595q.023.357.023.732v2.739h-.565v-4.9h.714l2.608 4.054h.03l-.018-.327-.024-.476q-.006-.262-.006-.483v-2.768h.577z\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m25.766 43.858-1.746 5.354M30.274 39.024l5.627-1.811M30.274 16.543l5.627 1.81M24.395 19.072l-3.168 4.356M24.395 36.495l-3.168-4.356M25.766 11.709 24.02 6.355M52.784 16.543l-5.627 1.81M58.663 19.072l3.168 4.356M58.663 36.495l3.168-4.356M52.784 39.024l-5.627-1.811M57.291 43.858l1.747 5.354M57.291 11.709l1.747-5.354\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Temgicoluril","UNII":"55FE6NPG89","Wikidata":"Q4286560","Wikipedia":"Temgicoluril","XLogP":-0.9}