{"ATC Code":["N - Nervous system","N05 - Psycholeptics","N05C - Hypnotics and sedatives","N05CA - Barbiturates, plain","N05CA07 - Talbutal","QN - Nervous system","QN05 - Psycholeptics","QN05C - Hypnotics and sedatives","QN05CA - Barbiturates, plain","QN05CA07 - Talbutal"],"Abbreviation":[],"Absorption, Distribution and Excretion":"THERE EXISTS NO IMPENETRABLE BARRIER TO DIFFUSION OF BARBITURATES IN BODY ... SMALL AMT ... MAY APPEAR IN MILK AFTER INGESTION OF LARGE DOSES. ... READILY CROSS PLACENTAL BARRIER, \u0026, WITHIN FEW MIN AFTER INJECTION OF SHORT-... ACTING BARBITURATE, CONCN IN FETAL BLOOD APPROACHES THAT IN MATERNAL VENOUS BLOOD. /BARBITURATES/","Aliases":["Talbutal","Lotusate","Profundol","5-Allyl-5-sec-butylbarbituric acid","115-44-6","Talbutale","Talbutalum","sec-Butyl allyl barbituric acid","WIN 5095","Barbituric acid, 5-allyl-5-sec-butyl-","4YIR8202AX","Dtxsid8023630","2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylpropyl)-5-(2-propenyl)-","Dtxcid403630","5-(butan-2-yl)-5-(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione","allyl-sec-butyl-barbituric acid","N05CA07","204-090-4","5-Allyl-5-(1-methylpropyl) barbituric acid","5-(1-Methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione","Talbumalum","2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methypropyl)-5-(2-propenyl)-","HSDB 3397","Einecs 204-090-4","Unii-4yir8202ax","Latusate","Talbutal ciii(250 mg)","Schembl122147","Chembl1200802","Chebi:134923","Tox21_113715","HY-U00276","5-(1-methylpropyl)-5-prop-2-en-1-ylpyrimidine-2,4,6(1H,3H,5H)-trione","CS-7222","DB00306","Ncgc00253567-01","Cas-115-44-6","NS00023740","D06887","Q409942","5-Allyl-5-sec-butyl-2,4,6(1H,3H,5H)-pyrimidinetrione","5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione","2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylpropyl)-5-(2-propen-1-yl)-"],"Biological Half-Life":"Half-life 15 hr","CAS":"115-44-6","ChemicalClasses":["barbiturate"],"Chirality":"racemic","Color/Form":"CRYSTALS FROM WATER OR DIL ALCOHOL","Drug Indication":"For use as a sedative and hypnotic.","Drug Warnings":"EVALUATION OF EFFECTS OF GENERAL DEPRESSANTS ON FETUS \u0026 NEONATES IS DIFFICULT, \u0026 PLACE THAT BARBITURATES SHOULD OCCUPY IN OBSTETRICS IS STILL CONTROVERSIAL. /BARBITURATES/","EliminationHalfLife":"","Esters":[],"European Community (EC) Number":"204-090-4","Formating":[],"HeavyAtomCount":16,"Human Drugs":"FDA approved drugs -\u003e Active ingredient","IUPACName":"5-butan-2-yl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione","InChI":"InChI=1S/C11H16N2O3/c1-4-6-11(7(3)5-2)8(14)12-10(16)13-9(11)15/h4,7H,1,5-6H2,2-3H3,(H2,12,13,14,15,16)","InChIKey":"BJVVMKUXKQHWJK-UHFFFAOYSA-N","Interactions":"... BARBITURATES MAY CAUSE DECR HYPOPROTHROMBINEMIC EFFECT OF ORAL ANTICOAGULANTS. ... BARBITURATES INTERACT WITH ADRENAL CORTICOSTEROIDS TO CAUSE REDUCED SERUM LEVELS \u0026 DECR SYSTEMIC EFFECTS OF STEROIDS; PROBABLE MECHANISM IS INDUCTION OF MICROSOMAL ACTIVITY. /BARBITURATES/","MeSH Headers":[{"Id":"M0413630","Link":"https://id.nlm.nih.gov/mesh/M0413630.html","Name":"talbutal","Ref":42},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":43},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":61}],"Mechanism of Action":"Talbutal binds to GABA\u003csub\u003eA\u003c/sub\u003e receptors at a distinct binding site associated with a Cl\u003csup\u003e-\u003c/sup\u003e ionopore of the receptor. Upon binding, talbutal increases the duration of time for which the Cl\u003csup\u003e-\u003c/sup\u003e ionopore is open, leading to prolonged inhibitory effect of GABA at the postsynaptic thalamic neuron.","Melting Point":"108-110 °C","Metabolism/Metabolites":"MOST BARBITURATES ARE TRANSFORMED IN BODY TO INACTIVE METABOLITES. PRINCIPAL SITE OF BIOTRANSFORMATION IS LIVER. OXYBARBITURATES ARE TRANSFORMED ONLY BY LIVER; THIOBARBITURATES MAY BE TRANSFORMED TO SMALL EXTENT IN OTHER TISSUES, ESP KIDNEY \u0026 BRAIN ... /BARBITURATES/","MolecularFormula":"C\u003csub\u003e11\u003c/sub\u003eH\u003csub\u003e16\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"224.26 g/mol","Odor":"MAY HAVE SLIGHT ODOR OF CARAMEL","Opticalactivity":"( + / - )","Pharmacodynamics":"Talbutal is a short to intermediate-acting barbiturate that is a nonselective central nervous system (CNS) depressant. As with other barbiturates, talbutal is capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. Barbiturates may also induce anesthesia at sufficiently high therapeutic doses.","PubChemId":8275,"Records":{"UNII":{"Impurities":[]}},"RefChem":"56087","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Talbutal","Name":"Talbutal","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q409942","Name":"Talbutal","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB00306","Name":"Talbutal","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/8275","Name":"Talbutal","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=115-44-6","Name":"Talbutal","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D06887","Name":"Talbutal","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/4YIR8202AX","Name":"Talbutal","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID8023630","Name":"Talbutal","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 8275, Talbutal. Accessed February 17, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/8275\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/8275\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Talbutal. UNII: 4YIR8202AX. Global Substance Registration System. Accessed February 17, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/4YIR8202AX\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/4YIR8202AX\u003c/a\u003e"],"SMILES":"CCC(C)C1(C(=O)NC(=O)NC1=O)CC=C","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Canada","ref":[],"schedule":"Schedule IV substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"}],"Solubility":"PRACTICALLY INSOL IN WATER \u0026 PETROLEUM ETHER SOL IN ALCOHOL, CHLOROFORM, ETHER, ACETONE, GLACIAL ACETIC ACID, FIXED ALKALI HYDROXIDE SOLN","StereoisomerData":[],"StereoisomerType":"enantiomer","Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 64.875 87.543\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h65v88H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m50.034 1.053-9.795 11.676M40.239 12.729l5.214 14.32M45.453 27.049l15.009 2.645M45.453 27.049l-9.795 11.676M35.658 38.725l-13.203 7.628\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M22.455 47.761 11.923 41.68M23.674 45.649l-10.532-6.081\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m11.923 41.68 5.266 3.041M13.142 39.568l5.266 3.04\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m22.455 46.353-.004 11.399M25.604 63.422l10.044 5.8\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m36.868 68.517.001 12.023M34.429 68.518l.002 12.022\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m36.869 80.54-.001-6.011M34.431 80.54l-.001-6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m35.648 69.222 10.05-5.807M48.853 57.743l.003-11.398M35.658 38.725l13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m47.637 45.641 10.528-6.077M48.856 47.753l10.528-6.077\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m58.165 39.564-5.264 3.038M59.384 41.676l-5.264 3.039\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"M35.658 38.725 25.86 27.052M25.86 27.052l-15.008 2.65\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M10.852 29.702 1.053 18.029M11.814 27.056 2.921 16.462\"/\u003e\u003c/g\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M11.516 38.73q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.882.506-.315 1.274-.315.732 0 1.232.315.5.31.756.876.256.565.256 1.327m-3.863 0q0 .923.386 1.459.393.529 1.221.529.839 0 1.22-.529.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524-.392.523-.392 1.452\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M24.391 64.051h-.72l-2.62-4.066h-.03l.03.596q.024.357.024.732v2.738h-.565v-4.899h.714l2.607 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482v-2.768h.578zM19.948 64.051h-.619v-2.286h-2.513v2.286h-.613v-4.899h.613v2.072h2.513v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M37.91 84.459q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875t.256 1.328m-3.863 0q0 .922.386 1.458.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.227.524-.392.524-.392 1.453\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M50.792 64.043h-.72l-2.619-4.066h-.03l.03.595q.023.357.023.732v2.739h-.565v-4.9h.714l2.608 4.054h.029l-.017-.327-.024-.476q-.006-.262-.006-.482v-2.769h.577zM55.098 64.043h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath fill=\"#ff0d0d\" stroke=\"none\" d=\"M64.315 38.724q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.732 0 1.232.315.5.31.756.875.256.566.256 1.328m-3.863 0q0 .923.386 1.458.393.53 1.221.53.839 0 1.22-.53.387-.535.387-1.458 0-.929-.387-1.453-.381-.524-1.208-.524-.834 0-1.227.524-.392.524-.392 1.453\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m22.451 57.752.002-5.699M22.451 57.752l.002-5.699M25.604 63.422l5.022 2.9M25.604 63.422l5.022 2.9M45.698 63.415l-5.025 2.904M48.853 57.743l.002-5.699\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Taste":"SLIGHTLY BITTER TASTE","Therapeutic Uses":"\"SHORT- TO INTERMEDIATE-ACTING\" COMPOUNDS ARE USED PRINCIPALLY AS SEDATIVE-HYPNOTIC AGENTS. /BARBITURATES, SHORT- TO INTERMEDIATE-ACTING/","Title":"Talbutal","UNII":"4YIR8202AX","Wikidata":"Q409942","Wikipedia":"Talbutal","XLogP":1.4,"pH":"SATURATED AQ SOLN IS ACID TO LITMUS"}