{"Aliases":["Setiptiline","Org-8282","Setiptilina","ORG 8282","Setiptilinum","MO 8282","Dtxsid50205886","MO-8282","Chebi:135076","13b,4a-carba-mianserin","1,2,3,4-tetrahydro-2-methyl-9H-dibenzo(3,4-6,7)cyclohepta(1,2-C)pyridine","Dtxcid80128377","260-653-4","4-methyl-4-azatetracyclo(13.4.0.02,?.0?,13)nonadeca-1(19),2(7),8,10,12,15,17-heptaene","2,3,4,9-Tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine","2,3,4,9-Tetrahydro-2-methyl-1H-dibenzo(3,4:6,7)cyclohepta(1,2-c)pyridine","1H-Dibenzo(3,4:6,7)cyclohepta(1,2-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-","Einecs 260-653-4","Brn 1650422","Unii-7l38105z6e","1H-Dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine, 2,3,4,9-tetrahydro-2-methyl-","2,3,4,9-Tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine; Org 8282; MO-8282; Teciptilline;","Tecipul","Schembl211362","orb1708532","Chembl2104895","Schembl29414110","MSK11204","EX-A11188","Mfcd00868385","Akos030526164","CS-1181","DB09304","Ncgc00378937-01","Ncgc00378937-02","AC-37639","DA-67551","HY-32329","MS-23683","NS00053323","D08511","F84903","T12900","F979845","L003337","Brd-k36732695-001-01-9","1,2,3,4-Tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine","2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine","4-methyl-4-azatetracyclo[13.4.0.0^{2,7.0^{8,13]nonadeca-1(19),2(7),8,10,12,15,17-heptaene","WOQ"],"CAS":"57262-94-9","ChemicalClasses":["phenethylamine"],"Chirality":"achiral","Drug Indication":"For the treatment of depression.","EliminationHalfLife":"","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"260-653-4","Formating":[],"HMDB ID":"HMDB0258262","HeavyAtomCount":20,"IUPACName":"4-methyl-4-azatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),2(7),8,10,12,15,17-heptaene","InChI":"InChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3","InChIKey":"GVPIXRLYKVFFMK-UHFFFAOYSA-N","KEGG Entries":[{"Id":"D02034","Interactions":[],"Synonyms":["Setiptiline maleate","Tecipul"]},{"Id":"D08511","Interactions":[],"Synonyms":["Setiptiline"]},{"Id":"D02034","Interactions":[],"Synonyms":["Setiptiline maleate","Tecipul"]},{"Id":"D08511","Interactions":[],"Synonyms":["Setiptiline"]}],"MeSH Headers":[{"Id":"M0144408","Link":"https://id.nlm.nih.gov/mesh/M0144408.html","Name":"setiptiline","Ref":26},{"Id":"M0144404","Link":"https://id.nlm.nih.gov/mesh/M0144404.html","Name":"MO 8282","Ref":28},{"Id":"M0144406","Link":"https://id.nlm.nih.gov/mesh/M0144406.html","Name":"ORG 8282","Ref":29},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":30},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":42}],"Mechanism of Action":"Setiptiline is an antagonist at the α2 adrenergic receptor and at serotonin receptors. The antagonism of the α2 receptors likely relieves presynaptic inhibition of adrenergic neurotransmission, allowing for greater and longer sustained release of noradrenaline into the synapse. The antagonism of serotonin receptors may produce an upregulation of the receptors leading to an eventual increase in serotonergic signalling. The actual physiological mechanisms behind the antidepressant effect of setiptiline is unknown but the listed possibilities exist as likely explanations.","MolecularFormula":"C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e19\u003c/sub\u003eN","MolecularWeight":"261.4 g/mol","Pharmacodynamics":"Setiptiline is a tertacyclic antidepressant. It acts to reduce the symptoms of major depressive disorder.","PubChemId":5205,"Records":{"UNII":{"Impurities":[]}},"RefChem":"182617","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Setiptiline","Name":"Setiptiline","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q6590424","Name":"Setiptiline","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB09304","Name":"Setiptiline","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5205","Name":"Setiptiline","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=57262-94-9","Name":"Setiptiline","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0258262","Name":"Setiptiline","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D08511","Name":"Setiptiline","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/7L38105Z6E","Name":"Setiptiline","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID50205886","Name":"Setiptiline","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 5205, Setiptiline. Accessed May 4, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/5205\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/5205\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Setiptiline. UNII: 7L38105Z6E. Global Substance Registration System. Accessed May 4, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7L38105Z6E\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/7L38105Z6E\u003c/a\u003e"],"SMILES":"CN1CCC2=C(C1)C3=CC=CC=C3CC4=CC=CC=C24","SaltData":[{"AcidCount":1,"Amine":"Setiptiline","AmineCount":1,"Formula":"O=C(O)CC(O)C(=O)O","Name":"maleate","RName":"maleate","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 173.976 85.779\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h174v86H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m40.726.998 3.326 10.774M48.527 16.313l11.553 2.635M60.08 18.948l4.495 14.562M64.575 33.51 54.211 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class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Setiptiline","UNII":"7L38105Z6E","Wikidata":"Q6590424","Wikipedia":"Setiptiline","XLogP":3.3}