{"Abbreviation":["SDX"],"Absorption, Distribution and Excretion":"Following a single dose of serdexmethylphenidate/dexmethylphenidate (52.3/10.4 mg) compared to extended-release dexmethylphenidate (40 mg) capsules in healthy volunteers under fasted conditions, the Cmax and AUC of dexmethylphenidate were 14.0 ng/mL and 186 ng\\*h/mL and 28.2 ng/mL and 248 ng\\*h/mL, respectively. The kinetics are approximately linear over a range of concentrations, with steady-state being reached after the third once-daily dose. Serdexmethylphenidate has a low oral bioavailability of 3%. The Tmax for both serdexmethylphenidate and dexmethylphenidate is approximately two hours under fasted conditions when coadministered. When serdexmethylphenidate is administered as a single entity, the dexmethylphenidate Tmax is approximately eight hours.  Different ratios of serdexmethylphenidate to dexmethylphenidate, 64/8, 56/12, and 48/16 mg, each equivalent to 40 mg of dexmethylphenidate, were tested in healthy adult volunteers under fasted conditions. In each case, dexmethylphenidate reached peak plasma concentrations in roughly two hours (mean between 1.6-1.8 hours), which gradually decreased over 24 hours. The Cmax varied from 15.5 ± 3.7 to 23.8 ± 5.7 ng/mL while the AUC0-24h varied from 187.0 ± 41.0 to 207 ± 54.4 ng\\*h/mL. Another study investigated the pharmacokinetics of serdexmethylphenidate/dexmethylphenidate (28/6 or 56/12 mg) in patients aged between six and 17 years of age. In general, the Cmax and AUC varied between cohorts and dose but were roughly equivalent when normalized for both dose and body weight.","Aliases":["KP-415 inner salt","Unii-0h8kz470dw","KP484","KP-484","Pyridinium, 3-((((1S)-1-carboxy-2-hydroxyethyl)amino)carbonyl)-1-(((((2R)-2-((1R)-2-methoxy-2-oxo-1-phenylethyl)-1-piperidinyl)carbonyl)oxy)methyl)-","serdexmetilfenidato","Azstarys","N-(1-((((2r)-2-((1r)-2-methoxy-2-oxo-1-phenylethyl)piperidine-1-carbonyl)oxy)methyl)pyridin-1-ium-3-carbonyl)-l-serinate","(2S)-3-hydroxy-2-((1-(((2R)-2-((1R)-2-methoxy-2-oxo-1-phenylethyl)piperidine-1-carbonyl)oxymethyl)pyridin-1-ium-3-carbonyl)amino)propanoate","serdexmethylphenidatum","GTPL11450"],"Biological Half-Life":"Following a single oral dose of 52.3 mg/10.4 mg serdexmethylphenidate/dexmethylphenidate, the mean plasma terminal elimination half-lives of each component were roughly 5.7 and 11.7 hours, respectively. At steady-state in healthy adults under fasted conditions, serdexmethylphenidate/dexmethylphenidate at 64/8, 56/12, and 48/16 mg resulted in a dexmethylphenidate half-life of between 8.5 ± 2.3 and 9.2 ± 3.5 hours.","CAS":"1996626-29-9","ChemicalClasses":["phenidate"],"Chirality":"absolute","Drug Indication":"Serdexmethylphenidate is a prodrug of [dexmethylphenidate] that is indicated in combination with [dexmethylphenidate] for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients aged six years and older.","DurationOfAction":"","EliminationHalfLife":"","Erowid Experience Reports":[],"Esters":[],"Formating":[],"HMDB ID":"HMDB0304844","HeavyAtomCount":36,"IUPACName":"(2S)-3-hydroxy-2-[[1-[[(2R)-2-[(1R)-2-methoxy-2-oxo-1-phenylethyl]piperidine-1-carbonyl]oxymethyl]pyridin-1-ium-3-carbonyl]amino]propanoate","InChI":"InChI=1S/C25H29N3O8/c1-35-24(33)21(17-8-3-2-4-9-17)20-11-5-6-13-28(20)25(34)36-16-27-12-7-10-18(14-27)22(30)26-19(15-29)23(31)32/h2-4,7-10,12,14,19-21,29H,5-6,11,13,15-16H2,1H3,(H-,26,30,31,32)/t19-,20+,21+/m0/s1","InChIKey":"UBZPNQRBUOBBLN-PWRODBHTSA-N","KEGG Entries":[{"Id":"D11989","Interactions":[],"Synonyms":["Serdexmethylphenidate and dexmethylphenidate","Azstarys"]}],"MeSH Headers":[],"Mechanism of Action":"Attention Deficit Hyperactivity Disorder (ADHD) is an early-onset neurodevelopmental disorder that often extends into adulthood and is characterized by developmentally inappropriate and impaired attention, impulsivity, and motor hyperactivity. Proper diagnosis is hindered by a lack of biological markers (based on symptoms alone), a spectrum of severity, and frequent comorbidities such as autism spectrum disorder, reading disabilities, developmental coordination disorders, and tic disorders. Although the underlying cause(s) is unclear, dopaminergic, noradrenergic, serotonergic, cholinergic, glutaminergic, and opioid neurotransmission likely plays a role.  Serdexmethylphenidate is a prodrug of the CNS stimulant [dexmethylphenidate](MPH), a common first-line treatment for ADHD. The main effect of MPH is to increase the extracellular levels of dopamine and norepinephrine, which has numerous potential downstream effects. This occurs mainly due to MPH's ability to inhibit the corresponding dopamine and norepinephrine monoamine transporters. Other studies have suggested additional possible MPH functions, including serotonin 5-HT1A receptor agonism, redistribution of vesicular monoamine transporter-2 (VMAT-2), and either direct or indirect activation of α2-adrenergic receptors. Overall, imaging studies reveal that MPH acts to alter brain activity in relevant regions associated with executive function, emotional regulation, reward processing, and working memory.","Metabolism/Metabolites":"Serdexmethylphenidate is converted to dexmethylphenidate in the lower gastrointestinal tract by as yet unknown enzymes. Following this, dexmethylphenidate is mainly converted to d-α-phenyl-piperidine acetic acid (d-ritalinic acid) in the liver by carboxylesterase 1A1. Other metabolites include the oxidation products 6-oxo-methylphenidate and p-hydroxy-methylphenidate, which are then de-esterified to oxo-ritalinic acid and p-hydroxy-ritalinic acid, respectively. Methylphenidate may also be trans-esterified to form ethylphenidate.","MolecularFormula":"C\u003csub\u003e25\u003c/sub\u003eH\u003csub\u003e29\u003c/sub\u003eN\u003csub\u003e3\u003c/sub\u003eO\u003csub\u003e8\u003c/sub\u003e","MolecularWeight":"499.5 g/mol","Opticalactivity":"UNSPECIFIED","Pharmacodynamics":"Serdexmethylphenidate is a prodrug of the CNS stimulant [dexmethylphenidate], which increases extracellular levels of dopamine and norepinephrine in the CNS, leading to altered neurotransmission. As a CNS stimulant, serdexmethylphenidate carries a risk of abuse, misuse, and dependence, which should be monitored. Also, CNS stimulants are associated with increased blood pressure, heart rate, and risk of serious cardiovascular reactions, including stroke, myocardial infarction, and sudden death; patients should be assessed before starting therapy and monitored for cardiovascular abnormalities. Similarly, CNS stimulants may also result in peripheral vasculopathy, including Raynaud's phenomenon. Due to its ability to alter neurological function, serdexmethylphenidate may exacerbate pre-existing psychoses, induce manic episodes in patients with bipolar disorder, or result in newly diagnosable manic or psychotic symptoms. Frequent, sustained, and painful erections, which may require medical attention, have been observed in patients who have been treated for some time with serdexmethylphenidate, often associated with a dose increase. Finally, like other CNS stimulants, serdexmethylphenidate has been associated with weight loss and growth retardation, which may require treatment interruption in serious cases.","PubChemId":134823895,"Records":{"UNII":{"Impurities":[]}},"RefChem":"182500","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Serdexmethylphenidate","Name":"Serdexmethylphenidate","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q106240837","Name":"Serdexmethylphenidate","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB16629","Name":"Serdexmethylphenidate","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/134823895","Name":"Serdexmethylphenidate","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=1996626-29-9","Name":"Serdexmethylphenidate","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0304844","Name":"Serdexmethylphenidate","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/0H8KZ470DW","Name":"Serdexmethylphenidate","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 134823895, Serdexmethylphenidate. Accessed May 8, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/134823895\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/134823895\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Serdexmethylphenidate. UNII: 0H8KZ470DW. Global Substance Registration System. Accessed May 8, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/0H8KZ470DW\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/0H8KZ470DW\u003c/a\u003e","Schedules of Controlled Substances: Placement of Serdexmethylphenidate in Schedule IV. June 24, 2022. Accessed May 8, 2026. \u003ca href=https://www.federalregister.gov/documents/2022/06/24/2022-13538/schedules-of-controlled-substances-placement-of-serdexmethylphenidate-in-schedule-iv\u003ehttps://www.federalregister.gov/documents/2022/06/24/2022-13538/schedules-of-controlled-substances-placement-of-serdexmethylphenidate-in-schedule-iv\u003c/a\u003e"],"SMILES":"COC(=O)[C@@H]([C@H]1CCCCN1C(=O)OC[N+]2=CC=CC(=C2)C(=O)N[C@@H](CO)C(=O)[O-])C3=CC=CC=C3","SaltData":[],"Salts":[],"Scheduling":[{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":["3"],"schedule":"Schedule I"}],"StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 100.357 177.439\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" 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