{"Abbreviation":"RTX","Aliases":["Reciniferatoxin","Lopain","(+)-resiniferatoxin","Mtx-071","MTX-71","6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)daphnetoxin 20-(3-hydroxy-5-methoxybenzeneacetate)","Benzeneacetic acid, 4-hydroxy-3-methoxy-, ((2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno(5,4-e)-1,3-benzodioxol-5-yl)methyl ester","[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-3-methoxyphenyl)acetate","Neuroclastin","((1R,2R,6R,10S,11R,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-(prop-1-en-2-yl)-12,14,18-trioxapentacyclo(11.4.1.01,10.02,6.011,15)octadeca-3,8-dien-8-yl)methyl 2-(4-hydroxy-3-methoxyphenyl)acetate"],"CAS":"57444-62-9","ChEBI":"CHEBI:8809","ChEMBL":"CHEMBL17976","ChemicalClasses":["carboxylic acid"],"Chirality":"absolute","Classes":null,"Dosing Info":[],"Drug Indication":"Investigated for use/treatment in interstitial cystitis and urinary incontinence.","DrugClasses":[],"European Community (EC) Number":"637-354-6","HeavyAtomCount":46,"IUPACName":"[(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate","InChI":"InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1","InChIKey":"DSDNAKHZNJAGHN-MXTYGGKSSA-N","MolecularFormula":"C\u003csub\u003e37\u003c/sub\u003eH\u003csub\u003e40\u003c/sub\u003eO\u003csub\u003e9\u003c/sub\u003e","MolecularWeight":"628.7 g/mol","Opticalactivity":"( + )","PrevSalts":[],"PubChemId":5702546,"Record Description":["Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. It is a diterpenoid, an ortho ester, a tertiary alpha-hydroxy ketone, a member of phenols, a monomethoxybenzene, an organic heteropentacyclic compound, a carboxylic ester and an enone.","Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).","Resiniferatoxin has been reported in Euphorbia unispina and Euphorbia resinifera with data available.","Resiniferatoxin is a naturally occurring capsaicin analog found in the latex of the cactus Euphorbia resinifera with analgesic activity. Resiniferatoxin (RTX) binds to and activates the transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the plasma membrane of primary afferent sensory neurons. This increases the permeability to cations, and leads to an influx of calcium and sodium ions. This results in membrane depolarization, causing an irritant effect, followed by desensitization of the sensory neurons thereby inhibiting signal conduction in afferent pain pathways and causing analgesia. TRPV1, a member of the transient receptor potential channel (TRP) superfamily, is a heat- and chemo-sensitive calcium/sodium ion channel that is selectively expressed in a subpopulation of pain-sensing primary afferent neurons.","RESINIFERATOXIN is a small molecule drug with a maximum clinical trial phase of III (across all indications) and has 4 investigational indications.","Resiniferatoxin (RTX) is a plant toxin and ultrapotent capsaicin analog that occurs in various species of plants, such as resin spurge (Euphorbia resinifera). It evokes a powerful irritant effect followed by desensitization and analgesia. (L1244)","Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. It is a diterpenoid, an ortho ester, a tertiary alpha-hydroxy ketone, a member of phenols, a monomethoxybenzene, an organic heteropentacyclic compound, a carboxylic ester and an enone."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Resiniferatoxin","Name":"Resiniferatoxin","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q3277888","Name":"Resiniferatoxin","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB06515","Name":"Resiniferatoxin","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/5702546","Name":"Resiniferatoxin","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL17976","Name":"Resiniferatoxin","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8809","Name":"Resiniferatoxin","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=57444-62-9","Name":"Resiniferatoxin","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/A5O6P1UL4I","Name":"Resiniferatoxin","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID00894764","Name":"Resiniferatoxin","Sub":false}]}],"SMILES":"C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)CC6=CC(=C(C=C6)O)OC)O)C)O[C@](O3)(O2)CC7=CC=CC=C7)C(=C)C","StoreUNII":["A5O6P1UL4I"],"StructureBase64":"<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" height="193.337mm" version="1.2" viewBox="0 0 166.483 193.337" width="166.483mm">
      
    <desc>Generated by the Chemistry Development Kit (http://github.com/cdk)</desc>
      
    <g fill="#FF0D0D" stroke="#000000" stroke-linecap="round" stroke-linejoin="round" stroke-width=".7">
            
        <rect fill="#FFFFFF" height="194.0" stroke="none" width="167.0" x=".0" y=".0"/>
            
        <g class="mol" id="mol1">
                  
            <path class="bond" d="M32.313 112.798l-15.331 -.541l.313 -2.077l.313 -2.077l14.809 4.002l-.104 .693z" fill="#000000" id="mol1bnd1" stroke="none"/>
                  
            <path class="bond" d="M37.952 126.983c-.142 .0 -.294 -.088 -.345 -.217l-5.568 -14.187c-.064 -.163 .035 -.389 .198 -.453c.034 -.014 .071 -.02 .109 -.02c.142 -.0 .294 .089 .345 .218l5.568 14.186c.004 -.004 .007 -.006 .01 -.006c.041 -.0 -.056 .4 -.208 .46c-.034 .013 -.071 .019 -.109 .019z" fill="#000000" id="mol1bnd2" stroke="none"/>
                  
            <line class="bond" id="mol1bnd3" x1="37.933" x2="53.003" y1="126.638" y2="128.909"/>
                  
            <line class="bond" id="mol1bnd4" x1="53.003" x2="62.505" y1="128.909" y2="116.994"/>
                  
            <line class="bond" id="mol1bnd5" x1="62.505" x2="56.937" y1="116.994" y2="102.808"/>
                  
            <line class="bond" id="mol1bnd6" x1="56.937" x2="41.867" y1="102.808" y2="100.536"/>
                  
            <line class="bond" id="mol1bnd7" x1="32.365" x2="41.867" y1="112.451" y2="100.536"/>
                  
            <line class="bond" id="mol1bnd8" x1="41.867" x2="34.247" y1="100.536" y2="87.338"/>
                  
            <g class="bond" id="mol1bnd9">
                        
                <line x1="34.159" x2="34.335" y1="86.999" y2="87.677"/>
                        
                <line x1="31.55" x2="31.873" y1="86.565" y2="87.807"/>
                        
                <line x1="28.941" x2="29.411" y1="86.131" y2="87.938"/>
                        
                <line x1="26.333" x2="26.949" y1="85.697" y2="88.068"/>
                        
                <line x1="23.724" x2="24.487" y1="85.262" y2="88.199"/>
                        
                <line x1="21.115" x2="22.025" y1="84.828" y2="88.329"/>
                        
                <line x1="18.506" x2="19.563" y1="84.394" y2="88.459"/>
                      
            </g>
                  
            <g class="bond" id="mol1bnd10">
                        
                <line x1="15.2" x2="19.034" y1="71.677" y2="86.427"/>
                        
                <line x1="18.006" x2="20.949" y1="72.778" y2="84.099"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd11" x1="15.2" x2="28.043" y1="71.677" y2="63.472"/>
                  
            <g class="bond" id="mol1bnd12">
                        
                <line x1="26.773" x2="27.503" y1="64.284" y2="52.106"/>
                        
                <line x1="29.207" x2="29.937" y1="64.43" y2="52.251"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="27.503" x2="27.137999999999998" y1="52.106" y2="58.19500000000001"/>
                <line class="hi" stroke="#FF0D0D" x1="29.937" x2="29.572000000000003" y1="52.251" y2="58.340500000000006"/>
            </g>
                  
            <line class="bond" id="mol1bnd13" x1="28.043" x2="39.815" y1="63.472" y2="73.152"/>
                  
            <line class="bond" id="mol1bnd14" x1="34.247" x2="39.815" y1="87.338" y2="73.152"/>
                  
            <line class="bond" id="mol1bnd15" x1="39.815" x2="54.378" y1="73.152" y2="68.659"/>
                  
            <line class="bond" id="mol1bnd16" x1="54.378" x2="66.97" y1="68.659" y2="77.244"/>
                  
            <g class="bond" id="mol1bnd17">
                        
                <line x1="68.109" x2="66.97" y1="92.442" y2="77.244"/>
                        
                <line x1="65.589" x2="64.626" y1="91.453" y2="78.598"/>
                      
            </g>
                  
            <path class="bond" d="M56.699 102.551l.476 .513l11.446 -8.473l-.184 -2.454l-.221 -2.949z" fill="#000000" id="mol1bnd18" stroke="none"/>
                  
            <line class="bond" id="mol1bnd19" x1="66.97" x2="80.168" y1="77.244" y2="69.624"/>
                  
            <line class="bond" id="mol1bnd20" x1="80.168" x2="80.168" y1="69.624" y2="58.306"/>
                  
            <line class="bond" id="mol1bnd21" x1="83.446" x2="93.366" y1="52.492" y2="46.764"/>
                  
            <g class="bond" id="mol1bnd22">
                        
                <line x1="92.147" x2="92.147" y1="47.468" y2="35.446"/>
                        
                <line x1="94.585" x2="94.585" y1="47.468" y2="35.446"/>
                      
                <line class="hi" stroke="#FF0D0D" x1="92.147" x2="92.147" y1="35.446" y2="41.457"/>
                <line class="hi" stroke="#FF0D0D" x1="94.585" x2="94.585" y1="35.446" y2="41.457"/>
            </g>
                  
            <line class="bond" id="mol1bnd23" x1="93.366" x2="106.564" y1="46.764" y2="54.384"/>
                  
            <line class="bond" id="mol1bnd24" x1="106.564" x2="119.763" y1="54.384" y2="46.764"/>
                  
            <g class="bond" id="mol1bnd25">
                        
                <line x1="119.758" x2="119.763" y1="31.516" y2="46.764"/>
                        
                <line x1="122.197" x2="122.201" y1="32.924" y2="45.357"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd26" x1="119.758" x2="132.956" y1="31.516" y2="23.896"/>
                  
            <g class="bond" id="mol1bnd27">
                        
                <line x1="146.159" x2="132.956" y1="31.524" y2="23.896"/>
                        
                <line x1="143.721" x2="132.956" y1="32.932" y2="26.712"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd28" x1="146.159" x2="146.164" y1="31.524" y2="46.773"/>
                  
            <g class="bond" id="mol1bnd29">
                        
                <line x1="132.966" x2="146.164" y1="54.393" y2="46.773"/>
                        
                <line x1="132.966" x2="143.725" y1="51.577" y2="45.365"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd30" x1="119.763" x2="132.966" y1="46.764" y2="54.393"/>
                  
            <line class="bond" id="mol1bnd31" x1="146.159" x2="156.076" y1="31.524" y2="25.799"/>
                  
            <line class="bond" id="mol1bnd32" x1="132.956" x2="132.958" y1="23.896" y2="12.577"/>
                  
            <line class="bond" id="mol1bnd33" x1="136.237" x2="146.158" y1="6.764" y2="1.038"/>
                  
            <g class="bond" id="mol1bnd34">
                        
                <line stroke="#000000" x1="39.472" x2="40.158" y1="73.084" y2="73.219"/>
                        
                <line stroke="#FF0D0D" x1="39.676" x2="40.935" y1="70.535" y2="70.783"/>
                        
                <line stroke="#FF0D0D" x1="39.881" x2="41.713" y1="67.987" y2="68.348"/>
                        
                <line stroke="#FF0D0D" x1="40.086" x2="42.49" y1="65.438" y2="65.912"/>
                        
                <line stroke="#FF0D0D" x1="40.29" x2="43.267" y1="62.89" y2="63.476"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd35" x1="15.2" x2="1.014" y1="71.677" y2="66.109"/>
                  
            <path class="bond" d="M42.141 100.755l-.548 -.437l-8.052 8.018l1.287 1.027l1.288 1.026z" fill="#000000" id="mol1bnd36" stroke="none"/>
                  
            <path class="bond" d="M76.073 137.917c-.057 -.0 -.112 -.013 -.158 -.04l-19.734 -11.338v.0l.435 -.558v.0l19.648 11.289c.02 -.02 .039 -.029 .056 -.029c.11 -.0 .148 .376 .073 .507c-.061 .105 -.194 .169 -.32 .169zM54.492 125.568l-19.022 -10.929c-.152 -.087 -.216 -.326 -.129 -.478c.06 -.105 .193 -.168 .32 -.168c.056 -.0 .111 .012 .158 .039l19.107 10.979v-.0l-.434 .557z" fill="#000000" id="mol1bnd37" stroke="none"/>
                  
            <line class="bond" id="mol1bnd38" x1="76.089" x2="76.597" y1="137.574" y2="126.269"/>
                  
            <path class="bond" d="M62.628 116.667l-.246 .655l10.266 5.259l.586 -1.56l.585 -1.56z" fill="#000000" id="mol1bnd39" stroke="none"/>
                  
            <line class="bond" id="mol1bnd40" x1="76.089" x2="65.007" y1="137.574" y2="140.632"/>
                  
            <line class="bond" id="mol1bnd41" x1="53.003" x2="59.229" y1="128.909" y2="138.341"/>
                  
            <path class="bond" d="M76.307 137.3l-.436 .548l12.062 12.048l.387 -2.568l.339 -2.249z" fill="#000000" id="mol1bnd42" stroke="none"/>
                  
            <line class="bond" id="mol1bnd43" x1="88.004" x2="85.733" y1="147.076" y2="162.146"/>
                  
            <g class="bond" id="mol1bnd44">
                        
                <line x1="97.658" x2="85.733" y1="171.649" y2="162.146"/>
                        
                <line x1="95.037" x2="85.313" y1="172.678" y2="164.929"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd45" x1="97.658" x2="95.386" y1="171.649" y2="186.719"/>
                  
            <g class="bond" id="mol1bnd46">
                        
                <line x1="81.19" x2="95.386" y1="192.285" y2="186.719"/>
                        
                <line x1="81.61" x2="93.185" y1="189.502" y2="184.963"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd47" x1="81.19" x2="69.265" y1="192.285" y2="182.782"/>
                  
            <g class="bond" id="mol1bnd48">
                        
                <line x1="71.537" x2="69.265" y1="167.712" y2="182.782"/>
                        
                <line x1="73.738" x2="71.886" y1="169.468" y2="181.753"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd49" x1="85.733" x2="71.537" y1="162.146" y2="167.712"/>
                  
            <g class="bond" id="mol1bnd50">
                        
                <line x1="53.298" x2="52.708" y1="129.098" y2="128.721"/>
                        
                <line x1="52.336" x2="51.325" y1="131.067" y2="130.421"/>
                        
                <line x1="51.375" x2="49.942" y1="133.036" y2="132.121"/>
                        
                <line x1="50.414" x2="48.559" y1="135.006" y2="133.821"/>
                        
                <line x1="49.452" x2="47.177" y1="136.975" y2="135.521"/>
                        
                <line x1="48.491" x2="45.794" y1="138.944" y2="137.221"/>
                        
                <line x1="47.53" x2="44.411" y1="140.914" y2="138.922"/>
                        
                <line x1="46.568" x2="43.028" y1="142.883" y2="140.622"/>
                      
            </g>
                  
            <g class="bond" id="mol1bnd51">
                        
                <line x1="44.798" x2="29.574" y1="141.752" y2="141.069"/>
                        
                <line x1="43.282" x2="29.464" y1="144.125" y2="143.505"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd52" x1="44.798" x2="51.818" y1="141.752" y2="155.279"/>
                  
            <path class="atom" d="M31.214 48.257q-.0 .756 -.256 1.327q-.256 .566 -.756 .881q-.5 .316 -1.244 .316q-.756 -.0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q-.0 -.75 .244 -1.31q.25 -.565 .756 -.881q.506 -.315 1.274 -.315q.732 -.0 1.232 .315q.5 .31 .756 .875q.256 .566 .256 1.328zM27.35 48.257q.0 .922 .387 1.458q.393 .53 1.221 .53q.839 .0 1.22 -.53q.387 -.536 .387 -1.458q.0 -.929 -.387 -1.453q-.381 -.524 -1.208 -.524q-.834 .0 -1.227 .524q-.393 .524 -.393 1.453z" id="mol1atm12" stroke="none"/>
                  
            <path class="atom" d="M82.427 54.382q.0 .756 -.256 1.327q-.256 .566 -.756 .881q-.5 .316 -1.244 .316q-.756 -.0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q-.0 -.75 .244 -1.31q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .566 .256 1.328zM78.564 54.382q-.0 .922 .387 1.458q.392 .53 1.22 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.458q.0 -.929 -.387 -1.453q-.381 -.524 -1.208 -.524q-.834 .0 -1.226 .524q-.393 .524 -.393 1.453z" id="mol1atm18" stroke="none"/>
                  
            <path class="atom" d="M95.625 31.522q.0 .756 -.256 1.327q-.256 .566 -.756 .881q-.5 .316 -1.244 .316q-.756 -.0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q.0 -.75 .244 -1.31q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .566 .256 1.328zM91.762 31.522q-.0 .922 .387 1.458q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.458q-.0 -.929 -.387 -1.453q-.381 -.524 -1.209 -.524q-.833 .0 -1.226 .524q-.393 .524 -.393 1.453z" id="mol1atm20" stroke="none"/>
                  
            <g class="atom" id="mol1atm28">
                        
                <path d="M161.617 23.902q-.0 .756 -.256 1.327q-.256 .566 -.756 .881q-.501 .316 -1.245 .316q-.756 -.0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q.0 -.75 .244 -1.31q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.233 .316q.5 .309 .756 .875q.256 .566 .256 1.328zM157.753 23.902q-.0 .922 .387 1.458q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.458q-.0 -.929 -.387 -1.453q-.381 -.524 -1.209 -.524q-.833 .0 -1.226 .524q-.393 .524 -.393 1.453z" stroke="none"/>
                        
                <path d="M165.923 26.354h-.619v-2.286h-2.513v2.286h-.613v-4.899h.613v2.071h2.513v-2.071h.619v4.899z" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M135.218 8.653q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.245 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.31q.25 -.565 .756 -.881q.506 -.315 1.274 -.315q.733 -.0 1.233 .315q.5 .31 .756 .876q.256 .565 .256 1.327zM131.354 8.653q.0 .923 .387 1.459q.393 .529 1.22 .529q.84 .0 1.221 -.529q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.453q-.381 -.523 -1.209 -.523q-.833 -.0 -1.226 .523q-.393 .524 -.393 1.453z" id="mol1atm29" stroke="none"/>
                  
            <g class="atom" id="mol1atm31">
                        
                <path d="M45.019 58.196q.0 .756 -.256 1.327q-.256 .566 -.756 .881q-.5 .316 -1.244 .316q-.756 .0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q-.0 -.75 .244 -1.31q.25 -.565 .756 -.881q.506 -.315 1.274 -.315q.732 -.0 1.232 .315q.5 .31 .756 .875q.256 .566 .256 1.328zM41.156 58.196q-.0 .923 .387 1.458q.393 .53 1.22 .53q.84 .0 1.221 -.53q.386 -.535 .386 -1.458q.0 -.929 -.386 -1.453q-.381 -.524 -1.209 -.524q-.833 .0 -1.226 .524q-.393 .524 -.393 1.453z" stroke="none"/>
                        
                <path d="M49.326 60.649h-.62v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.62v4.9z" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M34.624 112.448q.0 .756 -.256 1.328q-.256 .566 -.756 .881q-.5 .316 -1.244 .316q-.756 -.0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q-.0 -.751 .244 -1.31q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM30.761 112.448q-.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.386 -.536 .386 -1.459q.0 -.928 -.386 -1.452q-.381 -.524 -1.209 -.524q-.833 .0 -1.226 .524q-.393 .524 -.393 1.452z" id="mol1atm33" stroke="none"/>
                  
            <path class="atom" d="M79.032 122.346q.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q-.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM75.169 122.346q-.0 .923 .387 1.459q.392 .53 1.22 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.459q.0 -.928 -.387 -1.452q-.381 -.524 -1.208 -.524q-.834 -.0 -1.227 .524q-.392 .524 -.392 1.452z" id="mol1atm35" stroke="none"/>
                  
            <path class="atom" d="M63.658 141.625q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.245 .315q-.756 .0 -1.262 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.733 .0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM59.794 141.625q.0 .923 .387 1.459q.393 .53 1.22 .53q.84 -.0 1.221 -.53q.387 -.536 .387 -1.459q-.0 -.928 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .524 -.393 1.452z" id="mol1atm36" stroke="none"/>
                
            <line class="hi" id="mol1bnd7" stroke="#FF0D0D" x1="33.24463681552246" x2="37.116" y1="111.34798246085559" y2="106.4935"/>
            <line class="hi" id="mol1bnd20" stroke="#FF0D0D" x1="80.168" x2="80.168" y1="58.306" y2="63.964999999999996"/>
            <line class="hi" id="mol1bnd21" stroke="#FF0D0D" x1="83.446" x2="88.406" y1="52.492" y2="49.628"/>
            <line class="hi" id="mol1bnd31" stroke="#FF0D0D" x1="156.076" x2="151.1175" y1="25.799" y2="28.6615"/>
            <line class="hi" id="mol1bnd32" stroke="#FF0D0D" x1="132.958" x2="132.957" y1="12.577" y2="18.2365"/>
            <line class="hi" id="mol1bnd33" stroke="#FF0D0D" x1="136.237" x2="141.1975" y1="6.764" y2="3.9010000000000002"/>
            <line class="hi" id="mol1bnd38" stroke="#FF0D0D" x1="76.597" x2="76.34299999999999" y1="126.269" y2="131.9215"/>
            <line class="hi" id="mol1bnd40" stroke="#FF0D0D" x1="65.007" x2="70.548" y1="140.632" y2="139.103"/>
            <line class="hi" id="mol1bnd41" stroke="#FF0D0D" x1="59.229" x2="56.116" y1="138.341" y2="133.625"/>
        </g>
          
    </g>
    
</svg>
","Title":"Resiniferatoxin","UNII":"A5O6P1UL4I","Wikidata":"Q3277888","Wikipedia":"Resiniferatoxin","XLogP":4.5}