{"ATC Code":["N - Nervous system","N04 - Anti-parkinson drugs","N04B - Dopaminergic agents","N04BD - Monoamine oxidase b inhibitors","N04BD02","N04BD02 - Rasagiline","QN - Nervous system","QN04 - Anti-parkinson drugs","QN04B - Dopaminergic agents","QN04BD - Monoamine oxidase b inhibitors","QN04BD02 - Rasagiline"],"Absorption, Distribution and Excretion":"Rasagiline is rapidly absorbed following oral administration.  The absolute bioavailability of rasagiline is about 36%.","Actives":["(R)-1-Aminoindane"],"Aliases":["N-2-Propynyl-1-indanamine","TV-1030","Rasagilina","NSC-759639","(1R)-N-propargylindan-1-amine","Indan-1-yl-prop-2-ynyl-amine","1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-,","Dtxsid3041112","Chebi:63620","Agn-1135","rasagilinum","TVP-101","Dtxcid1021112","N04BD02","851-611-1","N-2-propynyl-1-indanamine","TVP-1022","TVP1022","N-(2-Propynyl)-2,3-dihydroinden-1-amine","(1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine","Mfcd00866571","1-Indanamine, N-2-propynyl-, (R)-","Azilect","RAS","CHEMBL887","N-(Prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine","1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R)-","2,3-dihydro-N-2-propynyl-1H-inden-1-amine","(1R)-2,3-dihydro-n-2-propyn-1-yl-1h-inden-1-amine","(+)-Rasagiline","(1R)-N-prop-2-ynylindan-1-amine","Unii-003n66ts6t","HSDB 7699","TV 1030","Schembl74699","Mls006012042","N-propargyl-1-(R)aminoindan","GTPL6641","orb1309706","Schembl6054642","BDBM10989","HMS3264K12","HMS3715L12","HMS3886N03","HMS6019L06","HY-14605AR","Pharmakon1600-01502333","AC-723","EBC-26128","HY-14605A","NSC759639","NSC789038","s5795","Akos006271452","Akos015837675","CCG-213034","DB01367","FS-3130","NSC 759639","NSC-789038","Smr002533187","SY012374","(1R)-N-(prop-2-yn-1-yl)indan-1-amine","DB-001111","NS00002143","D08469","En300-150047","Ab01562963_01","Ab01562963_02","F078410","Sr-00000006359","Sr-00000006359-3","N-(prop-2-ynyl)-2,3-dihydro-1H-inden-1-amine","Brd-k58114536-001-01-6","Brd-k58114536-066-02-7","1H-inden-1-amine, 2,3-dihydro-n-2-propynyl-, (r)-","1H-inden-1-amine, 2,3-dihydro-n-2-propyn-1-yl-, (1r)-","1204184-69-9"],"Biological Half-Life":"Rasagiline has a mean steady-state half life of 3 hours but there is no correlation of pharmacokinetics with its pharmacological effect because of its irreversible inhibition of MAO-B.","CAS":"136236-51-6","ChemicalClasses":["1-aminoindane"],"Chirality":"absolute","Classes":["Monoamine oxidase inhibitor","Prodrug"],"Drug Classes":["Breast Feeding","Lactation","Antiparkinson Agents","Monoamine Oxidase Inhibitors","Neuroprotective Agents"],"Drug Indication":"For the treatment of the signs and symptoms of idiopathic Parkinsons disease as initial monotherapy and as adjunct therapy to levodopa.","Drug Warnings":"When used as monotherapy, postural hypotension was reported in approximately 3% of patients treated with 1 mg rasagiline and 5% of patients treated with placebo. In the monotherapy trial, postural hypotension did not lead to drug discontinuation and premature withdrawal in the rasagiline or placebo treated patients. When used as an adjunct to levodopa, postural hypotension was reported in approximately 6% of patients treated with 0.5 mg rasagiline, 9% of patients treated with 1 mg rasagiline and 3% of patients treated with placebo. Postural hypotension led to drug discontinuation and premature withdrawal from clinical trials in one (0.7%) patient treated with rasagiline 1 mg/day, no patients treated with rasagiline 0.5 mg/day and no placebo-treated patients. Clinical trial data suggest that postural hypotension occurs most frequently in the first two months of rasagiline treatment and tends to decrease over time.","DurationOfAction":"","EliminationHalfLife":"3 hours","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"851-611-1","FDA Pharmacological Classification":[{"Name":"FDA UNII","ReferenceNumber":24,"Value":{"StringWithMarkup":[{"String":"003N66TS6T"}]}},{"Name":"Active Moiety","ReferenceNumber":24,"Value":{"StringWithMarkup":[{"String":"RASAGILINE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":24,"Value":{"StringWithMarkup":[{"String":"Established Pharmacologic Class [EPC] - Monoamine Oxidase Inhibitor"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":24,"Value":{"StringWithMarkup":[{"String":"Mechanisms of Action [MoA] - Monoamine Oxidase Inhibitors"}]}},{"Name":"FDA Pharmacology Summary","ReferenceNumber":24,"Value":{"StringWithMarkup":[{"Markup":[{"Extra":"CID-3052776","Length":10,"Start":0,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/Rasagiline"},{"Extra":"CID-3052776","Length":10,"Start":72,"Type":"PubChem Internal Link","URL":"https://pubchem.ncbi.nlm.nih.gov/compound/rasagiline"}],"String":"Rasagiline is a Monoamine Oxidase Inhibitor. The mechanism of action of rasagiline is as a Monoamine Oxidase Inhibitor."}]}},{"Name":"Non-Proprietary Name","ReferenceNumber":33,"Value":{"StringWithMarkup":[{"String":"RASAGILINE"}]}},{"Name":"Pharmacological Classes","ReferenceNumber":33,"Value":{"StringWithMarkup":[{"String":"Monoamine Oxidase Inhibitors [MoA]; Monoamine Oxidase Inhibitor [EPC]"}]}}],"Formating":[],"HMDB ID":"HMDB0015454","HeavyAtomCount":13,"Human Drugs":"Breast Feeding; Lactation; Antiparkinson Agents; Monoamine Oxidase Inhibitors; Neuroprotective Agents","IUPACName":"(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine","InChI":"InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1","InChIKey":"RUOKEQAAGRXIBM-GFCCVEGCSA-N","Interactions":"Antidepressant Agents, Selective Serotonin-reuptake Inhibitors (SSRIs): Potential pharmacologic interaction resembling serotonin syndrome (hyperthermia, rigidity, myoclonus, autonomic instability with rapid vital sign fluctuations, and mental status changes that may progress to extreme agitation, delirium, coma, and death). Concomitant use generally should be avoided. At least 14 days should elapse between discontinuance of rasagiline and initiation of an SSRI.Because both fluoxetine and its principal metabolite have relatively long half-lives, the manufacturer of rasagiline recommends that at least 5 weeks (or longer with high-dose or long-term fluoxetine therapy) elapse between discontinuance of fluoxetine therapy and initiation of rasagiline.","KEGG Entries":[{"Id":"D02562","Interactions":[{"Action":"inhibition","Target":"CYP1A2"},{"Action":"induction","Target":"CYP1A2"}],"Synonyms":["Rasagiline mesylate","Rasagiline mesilate","Azilect"]},{"Id":"D08469","Interactions":[{"Action":"inhibition","Target":"CYP1A2"},{"Action":"induction","Target":"CYP1A2"}],"Synonyms":["Rasagiline","Azilect"]},{"Id":"D10829","Interactions":[{"Action":"inhibition","Target":"CYP1A2"},{"Action":"induction","Target":"CYP1A2"}],"Synonyms":["Rasagiline tartrate","Rasagiline"]}],"MeSH Headers":[{"Id":"M0100095","Link":"https://id.nlm.nih.gov/mesh/M0100095.html","Name":"rasagiline","Ref":53},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":55},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":77},{"Id":"M0014029","Link":"https://id.nlm.nih.gov/mesh/M0014029.html","Name":"Monoamine Oxidase Inhibitors","Ref":78},{"Id":"M0028008","Link":"https://id.nlm.nih.gov/mesh/M0028008.html","Name":"Neuroprotective Agents","Ref":79}],"MeSH Pharmacological Classification":[{"Id":"M0014029","Link":"https://id.nlm.nih.gov/mesh/M0014029.html","Name":"Monoamine Oxidase Inhibitor","Ref":78},{"Id":"M0028008","Link":"https://id.nlm.nih.gov/mesh/M0028008.html","Name":"Neuroprotective Agent","Ref":79}],"Mechanism of Action":"The precise mechanisms of action of rasagiline is unknown. One mechanism is believed to be related to its MAO-B inhibitory activity, which causes an increase in extracellular levels of dopamine in the striatum. The elevated dopamine level and subsequent increased dopaminergic activity are likely to mediate rasagiline's beneficial effects seen in models of dopaminergic motor dysfunction.","Metabolism/Metabolites":"Rasagiline undergoes almost complete biotransformation in the liver prior to excretion. In vitro experiments indicate that both routes of rasagiline metabolism are dependent on the cytochrome P450 (CYP) system, with CYP 1A2 being the major isoenzyme involved in rasagiline metabolism.","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e13\u003c/sub\u003eN","MolecularWeight":"171.24 g/mol","Opticalactivity":"( + )","Pharmacodynamics":"Rasagiline is a propargylamine and an irreversible inhibitor of monoamine oxidase (MAO). MAO, a flavin-containing enzyme, regulates the metabolic degradation of catecholamines and serotonin in the CNS and peripheral tissues. It is classified into two major molecular species, A and B, and is localized in mitochondrial membranes throughout the body in nerve terminals, brain, liver and intestinal mucosa. MAO-A is found predominantly in the GI tract and liver, and regulates the metabolic degradation of circulating catecholamines and dietary amines. MAO-B is the major form in the human brain and is responsible for the regulation of the metabolic degradation of dopamine and phenylethylamine. In ex vivo animal studies in brain, liver and intestinal tissues rasagiline was shown to be a potent,selective, and irreversible monoamine oxidase type B (MAO-B) inhibitor. At the recommended therapeutic doses, Rasagiline was also shown to be a potent and irreversible inhibitor of MAO-B in platelets. The selectivity of rasagiline for inhibiting only MAO-B (and not MAO-A) in humans and the sensitivity to tyramine during rasagiline treatment at any dose has not been sufficiently characterized to avoid restriction of dietary tyramine and amines contained in medications.","Physical Description":"Solid","PubChemId":3052776,"Record Description":["LiverTox|CNS|Parkinsons agent|MAO inhibitor"],"Records":{"UNII":{"Impurities":[]}},"RefChem":"875177","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Rasagiline","Name":"Rasagiline","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q420685","Name":"Rasagiline","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB01367","Name":"Rasagiline","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/3052776","Name":"Rasagiline","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=136236-51-6","Name":"Rasagiline","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015454","Name":"Rasagiline","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D08469","Name":"Rasagiline","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/003N66TS6T","Name":"Rasagiline","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3041112","Name":"Rasagiline","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 3052776, rasagiline. Accessed May 6, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/3052776\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/3052776\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Rasagiline. UNII: 003N66TS6T. Global Substance Registration System. Accessed May 6, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/003N66TS6T\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/003N66TS6T\u003c/a\u003e","RASAGILINE JAMP/ RASAGILINE GXMED (AA-Med Pty Ltd) {-{!}."],"SMILES":"C#CCN[C@@H]1CCC2=CC=CC=C12","SaltData":[{"AcidCount":1,"Amine":"Rasagiline","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","RName":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 97.303 76.945\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h98v77H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m71.075 1.758-4.727 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