{"Abbreviation":"","Aliases":["(2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethylmorpholin-2-ol","radafaxina","2-Morpholinol, 2-(3-chlorophenyl)-3,5,5-trimethyl-, (2S,3S)-","GW 353162","2-Morpholinol, 2-(3-chlorophenyl)-3,5,5-trimethyl-, (2S-cis)-","radafaxinum","(S,S)-Hydroxy Bupropion","233600-52-7","(+)-(2S,3S)-2-(3-Chlorophenyl)-3,5,5-trimethyl-2-morpholinol","Hydroxybupropion (as (RS,RS)-cyclic Hemiketal)"],"CAS":"192374-14-4","ChEMBL":"CHEMBL1172928","ChemicalClasses":["phenylmorpholine"],"Chirality":"absolute","Dosing Info":[],"DrugClasses":[],"EliminationHalfLife":"","European Community (EC) Number":"689-763-4","FullSalts":["Radafaxine hydrochloride"],"HeavyAtomCount":17,"IUPACName":"(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol","InChI":"InChI=1S/C13H18ClNO2/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3/t9-,13+/m0/s1","InChIKey":"RCOBKSKAZMVBHT-TVQRCGJNSA-N","MolecularFormula":"C\u003csub\u003e13\u003c/sub\u003eH\u003csub\u003e18\u003c/sub\u003eClNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"255.74 g/mol","Opticalactivity":"UNSPECIFIED","PrevSalts":["hydrochloride"],"PubChemId":9795056,"Record Description":["Radafaxine has been used in trials studying the treatment of Depressive Disorder, Major.","RADAFAXINE is a small molecule drug with a maximum clinical trial phase of II and has 1 investigational indication."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Radafaxine","Name":"Radafaxine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q1485208","Name":"Radafaxine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB11790","Name":"Radafaxine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/9795056","Name":"Radafaxine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1172928","Name":"Radafaxine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=192374-14-4","Name":"Radafaxine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/Q47741214K","Name":"Radafaxine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID501318447","Name":"Radafaxine","Sub":false}]}],"SMILES":"C[C@H]1[C@@](OCC(N1)(C)C)(C2=CC(=CC=C2)Cl)O","Salts":["hydrochloride"],"SaltsAcidCount":[1],"SaltsAmineCount":[1],"SaltsUNII":["SYD411HZ3S"],"Scheduling":[],"StoreUNII":["Q47741214K"],"StructureBase64":"<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" height="46.287mm" version="1.2" viewBox="0 0 102.433 46.287" width="102.433mm">
      
    <desc>Generated by the Chemistry Development Kit (http://github.com/cdk)</desc>
      
    <g fill="#FF0D0D" stroke="#000000" stroke-linecap="round" stroke-linejoin="round" stroke-width=".7">
            
        <rect fill="#FFFFFF" height="47.0" stroke="none" width="103.0" x=".0" y=".0"/>
            
        <g class="mol" id="mol1">
                  
            <path class="bond" d="M63.643 29.305l-.537 -.45l-11.134 10.553l1.61 1.35l1.609 1.349z" fill="#000000" id="mol1bnd1" stroke="none"/>
                  
            <line class="bond" id="mol1bnd2" x1="63.374" x2="58.161" y1="29.08" y2="14.76"/>
                  
            <line class="bond" id="mol1bnd3" x1="58.161" x2="65.416" y1="14.76" y2="6.117"/>
                  
            <line class="bond" id="mol1bnd4" x1="71.603" x2="82.983" y1="3.721" y2="5.723"/>
                  
            <line class="bond" id="mol1bnd5" x1="82.983" x2="88.196" y1="5.723" y2="20.043"/>
                  
            <line class="bond" id="mol1bnd6" x1="88.196" x2="81.233" y1="20.043" y2="28.338"/>
                  
            <line class="bond" id="mol1bnd7" x1="63.374" x2="75.073" y1="29.08" y2="31.138"/>
                  
            <line class="bond" id="mol1bnd8" x1="88.196" x2="101.395" y1="20.043" y2="12.423"/>
                  
            <line class="bond" id="mol1bnd9" x1="88.196" x2="97.991" y1="20.043" y2="31.719"/>
                  
            <g class="bond" id="mol1bnd10">
                        
                <line x1="58.336" x2="57.986" y1="15.063" y2="14.457"/>
                        
                <line x1="56.282" x2="55.64" y1="16.586" y2="15.474"/>
                        
                <line x1="54.228" x2="53.294" y1="18.108" y2="16.492"/>
                        
                <line x1="52.174" x2="50.949" y1="19.631" y2="17.509"/>
                        
                <line x1="50.12" x2="48.603" y1="21.154" y2="18.526"/>
                        
                <line x1="48.066" x2="46.258" y1="22.676" y2="19.544"/>
                        
                <line x1="46.012" x2="43.912" y1="24.199" y2="20.561"/>
                      
            </g>
                  
            <g class="bond" id="mol1bnd11">
                        
                <line x1="44.962" x2="31.759" y1="22.38" y2="14.752"/>
                        
                <line x1="42.524" x2="31.759" y1="23.788" y2="17.567"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd12" x1="31.759" x2="18.561" y1="14.752" y2="22.372"/>
                  
            <g class="bond" id="mol1bnd13">
                        
                <line x1="18.561" x2="18.566" y1="22.372" y2="37.62"/>
                        
                <line x1="21.0" x2="21.004" y1="23.779" y2="36.213"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd14" x1="18.566" x2="31.769" y1="37.62" y2="45.249"/>
                  
            <g class="bond" id="mol1bnd15">
                        
                <line x1="31.769" x2="44.967" y1="45.249" y2="37.629"/>
                        
                <line x1="31.769" x2="42.528" y1="42.433" y2="36.221"/>
                      
            </g>
                  
            <line class="bond" id="mol1bnd16" x1="44.962" x2="44.967" y1="22.38" y2="37.629"/>
                  
            <line class="bond" id="mol1bnd17" x1="18.561" x2="6.875" y1="22.372" y2="15.627"/>
                  
            <path class="bond" d="M57.892 14.985l.537 -.45l-6.261 -9.479l-1.261 1.058l-1.261 1.058z" fill="#000000" id="mol1bnd18" stroke="none"/>
                  
            <path class="atom" d="M70.224 3.078q-.0 .756 -.256 1.328q-.256 .565 -.756 .881q-.5 .315 -1.244 .315q-.756 .0 -1.263 -.315q-.506 -.316 -.756 -.887q-.244 -.572 -.244 -1.334q.0 -.75 .244 -1.309q.25 -.566 .756 -.881q.507 -.316 1.274 -.316q.733 -.0 1.233 .316q.5 .309 .756 .875q.256 .565 .256 1.327zM66.36 3.078q.0 .923 .387 1.459q.393 .53 1.221 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.459q-.0 -.929 -.387 -1.452q-.381 -.524 -1.209 -.524q-.833 -.0 -1.226 .524q-.393 .523 -.393 1.452z" id="mol1atm4" stroke="none"/>
                  
            <g class="atom" id="mol1atm7">
                        
                <path d="M80.333 34.172h-.72l-2.62 -4.066h-.029q.012 .238 .029 .595q.024 .357 .024 .732v2.739h-.565v-4.9h.714l2.608 4.054h.029q-.006 -.107 -.018 -.327q-.011 -.22 -.023 -.476q-.006 -.262 -.006 -.483v-2.768h.577v4.9z" fill="#3050F8" stroke="none"/>
                        
                <path d="M80.196 39.633h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619v4.9z" fill="#3050F8" stroke="none"/>
                      
            </g>
                  
            <path class="atom" d="M2.906 12.938q-.786 .0 -1.239 .53q-.452 .524 -.452 1.446q-.0 .911 .417 1.447q.422 .53 1.268 .53q.321 -.0 .607 -.054q.291 -.059 .565 -.143v.536q-.274 .101 -.565 .149q-.292 .054 -.697 .054q-.744 -.0 -1.25 -.31q-.5 -.31 -.75 -.875q-.25 -.572 -.25 -1.34q.0 -.744 .268 -1.309q.274 -.566 .804 -.881q.529 -.322 1.279 -.322q.78 .0 1.352 .286l-.244 .524q-.226 -.101 -.506 -.185q-.274 -.083 -.607 -.083zM5.662 17.361h-.601v-5.215h.601v5.215z" fill="#1FF01F" id="mol1atm16" stroke="none"/>
                  
            <g class="atom" id="mol1atm17">
                        
                <path d="M50.625 3.082q-.0 .756 -.256 1.327q-.256 .566 -.756 .881q-.5 .316 -1.244 .316q-.756 -.0 -1.262 -.316q-.506 -.315 -.756 -.887q-.244 -.571 -.244 -1.333q-.0 -.75 .244 -1.31q.25 -.566 .756 -.881q.506 -.316 1.274 -.316q.732 .0 1.232 .316q.5 .309 .756 .875q.256 .566 .256 1.328zM46.761 3.082q.0 .922 .387 1.458q.393 .53 1.221 .53q.839 -.0 1.22 -.53q.387 -.536 .387 -1.458q.0 -.929 -.387 -1.453q-.381 -.524 -1.208 -.524q-.834 .0 -1.227 .524q-.393 .524 -.393 1.453z" stroke="none"/>
                        
                <path d="M45.545 5.534h-.619v-2.286h-2.513v2.286h-.613v-4.899h.613v2.071h2.513v-2.071h.619v4.899z" stroke="none"/>
                      
            </g>
                
            <line class="hi" id="mol1bnd3" stroke="#FF0D0D" x1="65.416" x2="61.7885" y1="6.116999999999999" y2="10.4385"/>
            <line class="hi" id="mol1bnd4" stroke="#FF0D0D" x1="71.603" x2="77.293" y1="3.721" y2="4.7219999999999995"/>
            <line class="hi" id="mol1bnd6" stroke="#3050F8" x1="81.233" x2="84.7145" y1="28.338" y2="24.1905"/>
            <line class="hi" id="mol1bnd7" stroke="#3050F8" x1="75.073" x2="69.2235" y1="31.138" y2="30.109"/>
            <line class="hi" id="mol1bnd17" stroke="#1FF01F" x1="6.875" x2="12.718" y1="15.627" y2="18.9995"/>
        </g>
          
    </g>
    
</svg>
","Title":"Radafaxine","UNII":"Q47741214K","Wikidata":"Q1485208","Wikipedia":"Radafaxine","XLogP":1.9}