{"ATC Code":"A11HA02","Abbreviation":[],"Absorption, Distribution and Excretion":"The B vitamins are readily absorbed from the gastrointestinal tract, except in malabsorption syndromes. Pyridoxine is absorbed mainly in the jejunum. The Cmax of pyridoxine is achieved within 5.5 hours.","Aliases":["Pyridoxine","65-23-6","Pyridoxol","Pyridoxin","Adermine","Gravidox","3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine","Hydoxin","Pyridoxolum","3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-","5-Hydroxy-6-methyl-3,4-pyridinedimethanol","Piridoxina","Pyridoxinum","Piridossina","3-Hydroxy-4,5-dimethylol-α-picoline","Hexabione","2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine","2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine","Vitamin V6","2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine","Chebi:16709","KV2JZ1BI6Z","2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine","NSC-759148","Dtxsid4023541","2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin","Dtxcid903541","3-hydroxy-2-Picoline-4,5-dimethanol","vitaminum b6","A11HA02","200-603-0","(5-Hydroxy-6-methylpyridine-3,4-diyl)dimethanol","12001-77-3","2-Picoline-4,5-dimethanol, 3-hydroxy-","VitaminB6","Einecs 200-603-0","4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol","Pyridoxine  free base","4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol","Prestwick0_000623","Prestwick1_000623","Prestwick2_000623","Prestwick3_000623","Mfcd00006335","Adermin hydrochloride","TimTec1_000657","Oprea1_061614","BSPBio_000586","CBDivE_015627","SPBio_002805","BPBio1_000646","Pyridoxine hydrogen chloride","M.V.I.-12","STK177324","DB00165","Cas-58-56-0","Smp2_000230","Ncgc00016261-01","Ncgc00016261-03","Bezatin","Pirivitol","C00314","Ac-907/25014218","2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine","Adermin","Pridoxine","Infuvite Pediatric","Cas-65-23-6","NSC36225","Sr-05000001644","Ncgc00164317-01","Unii-kv2jz1bi6z","M.V.I.-12 Lyophilized","UEG","Beesix","nchembio.93-comp1","Becilan","Benadon","Hexobion","Vitamin B6","Pyridoxine, \u003e=98%","Hexaβlin","Vitamin b6,hydrochloride","LS-134393","bmse000288","Schembl3506","CHEMBL1364","Bidd:pxr0180","Vitamin b6","P5669_sigma","orb1310115","Schembl11074402","Schembl30267871","HY-B1328R","MSK1507","Nsc36225","Pyridoxol, Vitamin B6, Gravidox","AIDS006784","HMS2093L07","HMS5082D11","KUC106691N","Pharmakon1600-01505453","Aids-006784","Albb-022452","HY-B1328","NCB30231","Tox21_113644","Tox21_300365","BBL005552","Bdbm50103505","c1302","EBC-04089","NSC759148","s3980","SBB065653","Zinc00049154","Akos005410791","Tox21_113644_1","CCG-213453","CS-W019950","NSC 759148","Vitamin B6 100 microg/mL in Methanol","Ncgc00016261-02","Ncgc00016261-04","Ncgc00016261-05","Ncgc00016261-08","Ncgc00164317-02","Ncgc00254340-01","AC-14512","DS-11013","SY101968","58-56-0","Ksc-11-207-23","Sbi-0206844.p001","5-Hydroxy-6-methylpyridine-3,4-dimethanol","DB-073595","NS00004187","ST50907853","En300-39851","4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol","D08454","O10129","4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol #","F209504","Q423746","Sr-05000001644-1","Sr-05000001644-3","Brd-k14349461-001-04-4","Brd-k14349461-003-13-1","2B3e07d2-e4cc-4cc5-b085-6070ba01f9f0","Z382721012","2-methyl-3-hydroxy-4-hydroxymethyl-5-hydroxymethyl pyridine","InChI=1/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H"],"Biological Half-Life":"The total adult body pool consists of 16 to 25 mg of pyridoxine.  Its half-life appears to be 15 to 20 days.","CAS":"65-23-6","Chemical Classes":"Biological Agents -\u003e Vitamins and Derivatives","ChemicalClasses":["pyridine"],"Chirality":"achiral","Drug Classes":["Breast Feeding","Lactation","Milk, Human","Vitamins"],"Drug Indication":"Pyridoxine is indicated for the treatment of vitamin B6 deficiency and for the prophylaxis of [DB00951]-induced peripheral neuropathy. It is also approved by Health Canada for the treatment of nausea and vomiting in pregnancy in a combination product with [DB00366] (as the commercially available product Diclectin).","DurationOfAction":"","EliminationHalfLife":"several weeks (see #Metabolism for details)","Esters":[],"European Community (EC) Number":"200-603-0","FDA Pharmacological Classification":"KV2JZ1BI6Z","Formating":[],"HMDB ID":"HMDB0000239","HeavyAtomCount":12,"Human Drugs":"Breast Feeding; Lactation; Milk, Human; Vitamins","IUPACName":"4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol","InChI":"InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3","InChIKey":"LXNHXLLTXMVWPM-UHFFFAOYSA-N","MeSH Pharmacological Classification":"A group of water-soluble vitamins, some of which are COENZYMES.","Mechanism of Action":"Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5'-phosphate (PNP), pyridoxal 5'-phosphate (PLP) and pyridoxamine 5'-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).","Melting Point":"159-162 °C","Metabolism/Metabolites":"Pyridoxine is a prodrug primarily metabolized in the liver. The metabolic scheme for pyridoxine is complex, with formation of primary and secondary metabolites along with interconversion back to pyridoxine. Pyridoxine's major metabolite is 4-pyridoxic acid.","MolecularFormula":"C\u003csub\u003e8\u003c/sub\u003eH\u003csub\u003e11\u003c/sub\u003eNO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"169.18 g/mol","Pharmacodynamics":"Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.","Physical Description":"White powder; [Alfa Aesar MSDS]","PubChemId":1054,"Record Description":["LiverTox|HDS: Nutritional Sup|General health|Vitamin B6","LiverTox|HDS: Nutritional Sup|Vitamins|Vitamin B"],"Records":{"UNII":{"Impurities":[]}},"RefChem":"6185","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Pyridoxine","Name":"Pyridoxine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q423746","Name":"Pyridoxine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00165","Name":"Pyridoxine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/1054","Name":"Pyridoxine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=65-23-6","Name":"Pyridoxine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0000239","Name":"Pyridoxine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C00314","Name":"Pyridoxine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/KV2JZ1BI6Z","Name":"Pyridoxine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4023541","Name":"Pyridoxine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 1054, Pyridoxine. Accessed January 6, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/1054\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/1054\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pyridoxine. UNII: KV2JZ1BI6Z. Global Substance Registration System. Accessed January 6, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/KV2JZ1BI6Z\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/KV2JZ1BI6Z\u003c/a\u003e","Pyridoxine 50mg Tablets - Summary of Product Characteristics (SmPC). April 27, 2015. Accessed January 6, 2026. \u003ca href=https://www.medicines.org.uk/emc/medicine/28135/SPC/Pyridoxine+50mg+Tablets/\u003ehttps://www.medicines.org.uk/emc/medicine/28135/SPC/Pyridoxine+50mg+Tablets/\u003c/a\u003e"],"SMILES":"CC1=NC=C(C(=C1O)CO)CO","SaltData":[{"AcidCount":1,"Amine":"Pyridoxine","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 103.169 59.431\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h104v60H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m73.135 56.423-13.197-7.622\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m49.883 54.602 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(T273)","UNII":"KV2JZ1BI6Z","Wikidata":"Q423746","Wikipedia":"Pyridoxine","XLogP":-0.8}