{"Abbreviation":"4-PO-DMT","Aliases":["Psilocybine","Cy 39","CY-39","Magic mushrooms","3-[2-(Dimethylamino)ethyl]-1H-indol-4-yl dihydrogen phosphate","4-22-00-05665","Indol-4-ol, 3-(2-(dimethylamino)ethyl)-, dihydrogen phosphate","Psilocybinum","Psilocibina","({3-[2-(dimethylamino)ethyl]-1H-indol-4-yl}oxy)phosphonic acid"],"CAS":"520-52-5","ChEBI":"CHEBI:8614","ChEMBL":"CHEMBL194378","ChemicalClasses":["tryptamine"],"Chirality":"achiral","Color/Form":"Crystals from boiling water","DEA no":7437,"Dosing Info":[],"DrugClasses":["hallucinogens"],"DurationOfAction":"Oral: 4–6\u0026nbsph (range 3–12\u0026nbsph) Intravenous injection: 15–30\u0026nbspmin (1\u0026nbspmg)","EINECS":"208-294-4","EliminationHalfLife":"Oral (as psilocin): 2.1–4.7\u0026nbsph (range 1.2–18.6\u0026nbsph) Intravenous administration (as psilocin): 1.2\u0026nbsph (range 1.8–4.5\u0026nbsph)","European Community (EC) Number":"208-294-4","HMDB ID":"HMDB0256899","HeavyAtomCount":19,"Human Drugs":"Rare disease (orphan) drug","IUPACName":"[3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate","InChI":"InChI=1S/C12H17N2O4P/c1-14(2)7-6-9-8-13-10-4-3-5-11(12(9)10)18-19(15,16)17/h3-5,8,13H,6-7H2,1-2H3,(H2,15,16,17)","InChIKey":"QVDSEJDULKLHCG-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations, and other alterations of mood and thinking. Despite the name, the feature that distinguishes these agents from other classes of drugs is their capacity to induce states of altered perception, thought, and feeling that are not experienced otherwise. (See all compounds classified as Hallucinogens.)","Melting Point":"220-228 °C","MolecularFormula":"C\u003csub\u003e12\u003c/sub\u003eH\u003csub\u003e17\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e4\u003c/sub\u003eP","MolecularWeight":"284.25 g/mol","Physical Description":"Solid; [Merck Index]","PrevSalts":[],"PubChemId":10624,"Record Description":["Psilocybin is a tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonanacatl or \"magic mushrooms\"). It has a role as a hallucinogen, a fungal metabolite, a prodrug and a serotonergic agonist. It is a tryptamine alkaloid, a tertiary amino compound and an organic phosphate. It is functionally related to a psilocin. It is a conjugate acid of a psilocybin(1-).","Psilocybin is a DEA Schedule I controlled substance. Substances in the DEA Schedule I have no currently accepted medical use in the United States, a lack of accepted safety for use under medical supervision, and a high potential for abuse. It is a Hallucinogenic substances substance.","Psilocybin has been investigated for the treatment of Anxiety and Stage IV Melanoma. In November, 2019, it was granted Breakthrough Therapy status by the FDA.","Psilocybine has been reported in Gymnopilus spectabilis, Deconica pseudobullacea, and other organisms with data available.","Psilocybine is a tryptamine alkaloid, isolated from various genera of fungi including the genus Psilocybe, with hallucinogenic, anxiolytic, and psychoactive activities. In vivo, psilocybine is rapidly dephosphorylated into the active compound psilocin, which activates serotonin 2A (5-HT2A) receptors in the central nervous system (CNS), mimicking the effects of serotonin.","PSILOCYBINE is a small molecule drug with a maximum clinical trial phase of III (across all indications) and has 24 investigational indications.","Psilocybin (pronounced /ˌsaɪlɵˈsaɪbɪn/ SYE-lə-SYE-bin) (also known as psilocybine) is a hallucinogenic (entheogenic, psychedelic) indole of the tryptamine family, found in psilocybin mushrooms. It is present in hundreds of species of fungi, including those of the genus Psilocybe, such as Psilocybe cubensis and Psilocybe semilanceata, but also reportedly isolated from a dozen or so other genera. Psilocybin mushrooms are commonly called \"sacred mushrooms,\" \"magic mushrooms,\" or more simply \"shrooms\". Possession, and in some cases usage, of psilocybin or psilocin has been outlawed in most countries across the globe. Proponents of its usage consider it to be an entheogen and a tool to supplement various types of practices for transcendence, including in meditation, psychonautics, and psychedelic psychotherapy. The intensity and duration of entheogenic effects of psilocybin mushrooms are highly variable, depending on species/cultivar of mushrooms, dosage, individual physiology, and set and setting. Though psilocybin rarely attracts much attention from mainstream media, when it does the focus tends to be on the recreational use, generally excluding any other uses of the drug. (L1143)","The major of two hallucinogenic components of the sacred Teonanacatl mushrooms (see PSILOCYBE), the other component being PSILOCIN.","Psilocybin is a tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonanacatl or \"magic mushrooms\"). It has a role as a hallucinogen, a fungal metabolite, a prodrug and a serotonergic agonist. It is a tryptamine alkaloid, a tertiary amino compound and an organic phosphate. It is functionally related to a psilocin. It is a conjugate acid of a psilocybin(1-)."],"References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Psilocybin","Name":"Psilocybin","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q208118","Name":"Psilocybin","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB11664","Name":"Psilocybin","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/10624","Name":"Psilocybin","Sub":false}]},{"Name":"ChemSpider","Urls":[{"Link":"https://www.chemspider.com/Chemical-Structure.10178.html","Name":"Psilocybin","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL194378","Name":"Psilocybin","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8614","Name":"Psilocybin","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=520-52-5","Name":"Psilocybin","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0256899","Name":"Psilocybin","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07576","Name":"Psilocybin","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/2RV7212BP0","Name":"Psilocybin","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID0048898","Name":"Psilocybin","Sub":false}]}],"SMILES":"CN(C)CCC1=CNC2=C1C(=CC=C2)OP(=O)(O)O","Scheduling":[{"gov":"Australia","schedule":"S9/S8 (Controlled Drug) substance"},{"gov":"Brazil","schedule":"F2 substance"},{"gov":"Canada","schedule":"Schedule III substance"},{"gov":"United Kingdom","schedule":"Class A substance"},{"gov":"United States","schedule":"Schedule I substance"}],"Solubility":"Soluble in 120 parts boiling methanol; difficultly soluble in ethanol; practically insoluble in chloroform, benzene.","StoreUNII":["2RV7212BP0"],"StructureBase64":"<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" height="85.426mm" version="1.2" viewBox="0 0 98.638 85.426" width="98.638mm">
      
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