{"Aliases":["Benzedrex","Hydromethamphetamine","Dristan Inhaler","Propilhexedrina","Propylhexadrine","Propylhexedrinum","1-Cyclohexyl-2-(methylamino)propane","Propilesedrina","Methyl-(1-methyl-2-cyclohexylethyl)amine","NSC-32410","(1-cyclohexylpropan-2-yl)(methyl)amine","N,α-Dimethylcyclohexaneethylamine","NSC32410","Propylhexedrine dl-","Cyclohexaneethanamine, N,α-dimethyl-","222-741-0","Propylhexedrin","Dristan","Obesin","Hexahydrodesoxyephedrine","CHP-Depot","(+/-) Propylhexedrine","1-Cyclohexyl-N-methyl-2-propanamine","NSC 32410","1-Cyclohexyl-2-methylaminopropan","Ncgc00182042-01","Cyclohexaneethylamine, N-α-dimethyl-","(2-cyclohexyl-isopropyl)methylamine","cyclohexane, (2-methylamino)propyl-","Einecs 202-939-3","Brn 3194303","(Cyclohexaneethyl)amine, N-α-dimethyl-","β-Cyclohexyl-isopropylmethylamin","Cyclohexaneethanamine, N,α-dimethyl-,","Einecs 222-741-0","Dristan inhaler","Propylhexedrine dl-form","Cyclohexaneethylamine, α,n-dimethyl-","Cyclohexaneethanamine, N,α-dimethyl-, (+-)-","Schembl28537","3-12-00-00108","Dtxcid303526","Chembl2105275","Wln: l6tj a1y1\u0026m1","Chebi:134783","N-Methyl-1-cyclohexylisopropylamine","GAA19297","Tox21_113077","SBB050337","STK664138","Akos005172629","α,N-Dimethylcyclohexaneethylamine","Cyclohexaneethanamine,α-dimethyl-","DB06714","Ncgc00182042-03","Ncgc00182042-04","Cas-101-40-6","N-α-(Dimethylcyclohexane)ethylamine","Cyclohexaneethylamine, α,N-dimethyl-","ST4139488","NS00078933","D05637","En300-135610","Ab01331925-02","(.+/-.)-N,α-Dimethylcyclohexaneethylamine","N,α-dimethylcyclohexaneethanamine","Brd-a35667010-001-01-8"],"CAS":"101-40-6","ChemicalClasses":["cycloalkylamine"],"Chirality":"racemic","DBI-IGS":["Propylhexedrine"],"DTXSID":"1023526","Dosing Info":[{"Method":"Oral","Tiers":{"Common":{"Entries":0,"Lower":133.5,"Percentage":0,"Unit":"mg","Upper":187.5},"Extreme":{"Entries":1,"Lower":325,"Percentage":12.5,"Unit":"mg","Upper":325},"Heavy":{"Entries":0,"Lower":250,"Percentage":0,"Unit":"mg","Upper":325},"Light":{"Entries":4,"Lower":133.5,"Percentage":50,"Unit":"mg","Upper":133.5},"Strong":{"Entries":3,"Lower":187.5,"Percentage":37.5,"Unit":"mg","Upper":250}}}],"Drug Indication":"It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.","EliminationHalfLife":"4 ± 1.5 hours","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"222-741-0","Formating":[],"HMDB ID":"HMDB0015659","HeavyAtomCount":11,"Human Drugs":"Pharmaceuticals","IUPACName":"1-cyclohexyl-N-methylpropan-2-amine","InChI":"InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3","InChIKey":"JCRIVQIOJSSCQD-UHFFFAOYSA-N","MeSH Headers":[{"Id":"M0225274","Link":"https://id.nlm.nih.gov/mesh/M0225274.html","Name":"propylhexedrine","Ref":50},{"Id":"M0225272","Link":"https://id.nlm.nih.gov/mesh/M0225272.html","Name":"Benzedrex","Ref":52},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":53},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":71}],"Mechanism of Action":"Propylhexidrine causes the norepinephrine, dopamine, and serotonin (5HT) transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse. It also antagonizes the action of VMAT2, causing the release of more neurotransmitters.","MolecularFormula":"C\u003csub\u003e10\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eN","MolecularWeight":"155.28 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).","Physical Description":"Solid","PubChemId":7558,"PubChemTitle":"Propylhexedrine","Records":{"UNII":{"Impurities":["n-nitroso-propylhexedrine"]}},"Reddit Experience Reports":[],"RefChem":"55927","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Propylhexedrine","Name":"Propylhexedrine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q408704","Name":"Propylhexedrine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB06714","Name":"Propylhexedrine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/7558","Name":"Propylhexedrine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=101-40-6","Name":"Propylhexedrine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015659","Name":"Propylhexedrine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D05637","Name":"Propylhexedrine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/LQU92IU8LL","Name":"Propylhexedrine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023526","Name":"Propylhexedrine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 7558, Propylhexedrine. Accessed August 23, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/7558\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/7558\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Propylhexedrine. UNII: LQU92IU8LL. Global Substance Registration System. 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