{"Abbreviation":[],"Aliases":["Propylhexedrine","Benzedrex","Hydromethamphetamine","Dristan Inhaler","Propilhexedrina","Propylhexadrine","Propylhexedrinum","propylhexedrine","Propilesedrina","Methyl-(1-methyl-2-cyclohexylethyl)amine","1-Cyclohexyl-2-(methylamino)propane","N,α-Dimethylcyclohexaneethylamine","(1-cyclohexylpropan-2-yl)(methyl)amine","Propylhexedrine dl-","Cyclohexaneethanamine, N,α-dimethyl-","RefChem:55927","222-741-0","Propylhexedrin","Dristan","Obesin","Hexahydrodesoxyephedrine","CHP-Depot","1-Cyclohexyl-N-methyl-2-propanamine","1-Cyclohexyl-2-methylaminopropan","(+/-) Propylhexedrine"],"CAS":"101-40-6","ChEBI":"CHEBI:134783","ChEMBL":"CHEMBL2105275","ChemicalClasses":[],"Chirality":"racemic","Drug Indication":"It is used to provide temporary symptomatic relief of nasal congestion due to colds, allergies and allergic rhinitis.","EINECS":"202-939-3","EliminationHalfLife":"4 ± 1.5 hours","Esters":[],"European Community (EC) Number":"222-741-0","Formating":[],"HMDB ID":"HMDB0015659","HeavyAtomCount":11,"Human Drugs":"Pharmaceuticals","IUPACName":"1-cyclohexyl-N-methylpropan-2-amine","Impurities":["n-nitroso-propylhexedrine"],"InChI":"InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3","InChIKey":"JCRIVQIOJSSCQD-UHFFFAOYSA-N","LD50":[{"dosages":[{"amount":"83 mg/kg","route":"oral"}],"organism":"Rat"},{"dosages":[{"amount":"190 mg/kg","route":"oral"},{"amount":"92 mg/kg","route":"subcutaneous"},{"amount":"32 mg/kg","route":"intravenous"}],"organism":"Mouse"}],"MolecularFormula":"C\u003csub\u003e10\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eN","MolecularWeight":"155.28 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Like other monoamine releasing stimulants propylhexedrine is active as a norepinephrine and dopamine releaser in the central nervous system. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar).","Physical Description":"Solid","PubChemId":7558,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Propylhexedrine","Name":"Propylhexedrine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q408704","Name":"Propylhexedrine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB06714","Name":"Propylhexedrine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/7558","Name":"Propylhexedrine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL2105275","Name":"Propylhexedrine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:134783","Name":"Propylhexedrine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=101-40-6","Name":"Propylhexedrine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015659","Name":"Propylhexedrine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D05637","Name":"Propylhexedrine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/LQU92IU8LL","Name":"Propylhexedrine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID1023526","Name":"Propylhexedrine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 7558, Propylhexedrine. Accessed October 8, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/7558\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/7558\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Propylhexedrine. UNII: LQU92IU8LL. Global Substance Registration System. Accessed October 8, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/LQU92IU8LL\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/LQU92IU8LL\u003c/a\u003e"],"SMILES":"CC(CC1CCCCC1)NC","SaltData":[{"AcidCount":1,"Amine":"Propylhexedrine","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 104.179 39.997\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h105v40H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"M27.435 31.331v-15.24M27.435 16.091l13.198-7.62M40.633 8.471l13.198 7.62M53.831 16.091l13.203-7.629M67.034 8.462l13.198 7.62M80.232 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