{"ATC Code":"N - Nervous system","Abbreviation":["HWA 285","HWA-285"],"Aliases":["Propentophylline","HWA 285","HWA-285","Propentofyllinum","3,7-Dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione","Propentofilina","1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-","1-(5'-oxohexyl)-3-methyl-7-propylxanthine","RefChem:869635","N06BC02","3-methyl-1-(5-oxohexyl)-7-propyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione","611-242-7","Hextol","3-Methyl-1-(5-oxohexyl)-7-propylxanthine","3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6(3H,7H)-dione","Karsivan","Ncgc00015861-04","Albert-285","3-Methyl-1-(5-Oxohexyl)-7-Propyl-3,7-Dihydro-1h-Purine-2,6-Dione","Propentofylina","HOE-285","Cas-55242-55-2","Sr-01000075642","Viviq","3arx"],"CAS":"55242-55-2","ChEBI":"CHEBI:32061","ChEMBL":"CHEMBL1079905","ChemicalClasses":["xanthine"],"Chirality":"achiral","Drug Indication":"Investigated for use/treatment in alzheimer's disease.","EliminationHalfLife":"","Esters":[],"European Community (EC) Number":"611-242-7","Formating":[],"HMDB ID":"HMDB0256822","HeavyAtomCount":22,"Human Drugs":"Pharmaceuticals","IUPACName":"3-methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione","InChI":"InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3","InChIKey":"RBQOQRRFDPXAGN-UHFFFAOYSA-N","LD50":[{"dosages":[{"amount":"780 mg/kg","route":"oral"},{"amount":"346 mg/kg","route":"intraperitoneal"},{"amount":"450 mg/kg","route":"subcutaneous"},{"amount":"107 mg/kg","route":"intravenous"}],"organism":"Mouse"},{"dosages":[{"amount":"405 mg/kg","route":"oral"},{"amount":"89 mg/kg","route":"intravenous"}],"organism":"Rabbit"},{"dosages":[{"amount":"940 mg/kg","route":"oral"},{"amount":"196 mg/kg","route":"intraperitoneal"},{"amount":"338 mg/kg","route":"subcutaneous"},{"amount":"180 mg/kg","route":"intravenous"}],"organism":"Rat"}],"MeSH Pharmacological Classification":"Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.","MolecularFormula":"C\u003csub\u003e15\u003c/sub\u003eH\u003csub\u003e22\u003c/sub\u003eN\u003csub\u003e4\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"306.36 g/mol","PubChemId":4938,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Propentofylline","Name":"Propentofylline","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q2888695","Name":"Propentofylline","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB06479","Name":"Propentofylline","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/4938","Name":"Propentofylline","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1079905","Name":"Propentofylline","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32061","Name":"Propentofylline","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=55242-55-2","Name":"Propentofylline","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0256822","Name":"Propentofylline","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/D01630","Name":"Propentofylline","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/5RTA398U4H","Name":"Propentofylline","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID4045189","Name":"Propentofylline","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 4938, Propentofylline. Accessed September 15, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/4938\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/4938\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Propentofylline. UNII: 5RTA398U4H. Global Substance Registration System. Accessed September 15, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/5RTA398U4H\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/5RTA398U4H\u003c/a\u003e"],"SMILES":"CCCN1C=NC2=C1C(=O)N(C(=O)N2C)CCCCC(=O)C","SaltData":[],"Salts":[],"Scheduling":[],"StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 146.539 76.812\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h147v77H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"M145.538 1.001 140.81 15.49M140.81 15.49l-14.91 3.15M125.9 18.64l-3.494 10.707M123.777 36.71l6.336 8.712\" class=\"bond\"/\u003e\u003cg 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