{"ATC Code":"N04AA04","Abbreviation":"","Aliases":["Procyclidine","procyclidine","Kemadrine","Tricoloid","Arpicolin","Elorine","Lergine","Vagosin","Osnervan","Spamol","Procyklidin","Triciclidina","Metanin","Procidlidina","Prociclidina","Procyclidinum","Prosyklidin","Triciloid","1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol","1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol","1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol","1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-","5-20-01-00250","1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride","Procyclidin"],"Biological Half-Life":"The pharmacokinetics and pharmacodynamics of procyclidine (10 mg) after oral and intravenous administration were studied in six healthy volunteers. ... Plasma elimination half-life of procyclidine ... was .... 12 hr.","CAS":"77-37-2","ChEBI":"CHEBI:8448","ChEMBL":"CHEMBL86715","ChemicalClasses":["ethylamine"],"Classes":["Anticholinergic"],"Color/Form":"Crystals from petroleum ether","Decomposition":"When heated to decomposition it emits toxic fumes of NOx.","Drug Indication":"For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents.","Drug Warnings":"... Patients with hypotension receiving therapy with procyclidine should be observed closely. Patients with mental disorders receiving procyclidine for control of drug-induced extrapyramidal effects should also be carefully observed, especially at the beginning of therapy or during dosage adjustment, since worsening of mental symptoms or toxic psychosis can occur.","EINECS":"201-023-0","Esters":[],"European Community (EC) Number":"201-023-0","FDA Pharmacological Classification":"C6QE1Q1TKR","Formating":[],"HMDB ID":"HMDB0014531","HeavyAtomCount":21,"Human Drugs":"Human drug -\u003e Discontinued","IUPACName":"1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol","InChI":"InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2","InChIKey":"WYDUSKDSKCASEF-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Agents used in the treatment of Parkinson\u0026apos;s disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)","Melting Point":"85.5 to 86.5 °C","MolecularFormula":"C\u003csub\u003e19\u003c/sub\u003eH\u003csub\u003e29\u003c/sub\u003eNO","MolecularWeight":"287.4 g/mol","Pharmacodynamics":"Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.","Physical Description":"Solid","PubChemId":4919,"RefCount":2,"RefCur":"","References":[{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q268997","Name":"Procyclidine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB00387","Name":"Procyclidine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/4919","Name":"Procyclidine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL86715","Name":"Procyclidine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8448","Name":"Procyclidine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=77-37-2","Name":"Procyclidine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0014531","Name":"Procyclidine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07378","Name":"Procyclidine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/C6QE1Q1TKR","Name":"Procyclidine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID2023515","Name":"Procyclidine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 4919, Procyclidine. 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hydrochloride","Procyclidin"],"PubChemId":4919,"SMILES":"C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O","Structure":null,"Title":null,"UNII":"C6QE1Q1TKR"}],"Stereoisomers":["(-)-Procyclidine","Procyclidine"],"Structure":"\u003csvg  preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 105.422 70.256\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h106v71H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m104.379 61.589-13.203 7.629M91.176 69.218l-13.198-7.62M77.978 61.598l.005-15.249M77.983 46.349l13.203-7.628M91.186 38.721l13.198 7.62M104.379 61.589l.005-15.248M77.983 46.349l-13.199-7.62M64.784 38.729l-13.198 7.62M51.586 46.349l-13.198-7.62M38.388 38.729l-10.045 5.8M21.97 44.918 11.3 40.173M11.3 40.173 1.054 51.485M1.054 51.485l7.62 13.198M8.674 64.683l14.92-3.217M24.784 50.192l-1.19 11.274M64.784 38.729l-9.796-11.674\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m54.988 27.055 5.22-14.327M53.179 24.898l4.256-11.682\"/\u003e\u003c/g\u003e\u003cpath d=\"M60.208 12.728 50.412 1.053\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M50.412 1.053 35.396 3.706M49.449 3.699 37.206 5.862\"/\u003e\u003c/g\u003e\u003cpath d=\"m35.396 3.706-5.22 14.327\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m30.176 18.033 9.796 11.675M32.949 17.545l7.986 9.516\"/\u003e\u003c/g\u003e\u003cpath d=\"m54.988 27.055-15.016 2.653M64.784 38.729l7.249-8.638\" class=\"bond\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M27.13 48.799h-.72l-2.619-4.066h-.03l.03.595q.024.358.024.733v2.738h-.566V43.9h.714l2.608 4.054h.03l-.018-.328-.024-.476q-.006-.262-.006-.482V43.9h.577z\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M76.84 27.052q0 .756-.256 1.327-.256.566-.756.882-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.888-.244-.571-.244-1.333 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.733 0 1.233.315.5.31.756.875.256.566.256 1.328m-3.864 0q0 .923.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.535.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453M81.146 29.505h-.619v-2.286h-2.512v2.286h-.614v-4.9h.614v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#3050f8\" d=\"m28.343 44.529 5.022-2.9M21.97 44.918l-5.335-2.372M24.784 50.192l-.595 5.637\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m72.033 30.091-3.624 4.319\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Therapeutic Uses":"Discontinued ... Kemadrin (procyclidine hydrochloride) tablets will remain available ... until current supplies are deleted. /Procyclidine hydrochloride/","Title":"Procyclidine","UNII":"C6QE1Q1TKR","Wikidata":"Q268997","XLogP":4.1}