{"ATC Code":["N - Nervous system","N06 - Psychoanaleptics","N06B - Psychostimulants, agents used for adhd and nootropics","N06BX - Other psychostimulants and nootropics","N06BX15 - Pipradrol","QN - Nervous system","QN06 - Psychoanaleptics","QN06B - Psychostimulants, agents used for adhd and nootropics","QN06BX - Other psychostimulants and nootropics","QN06BX15 - Pipradrol"],"Absorption, Distribution and Excretion":"Rapidly absorbed.","Aliases":["Pipralon","Piridrol","Pyridrol","Pyridrole","Pipradol","α-Pipradol","Gerodyl","Pipradrolum","Pipradrolo","α-(2-Piperidyl)benzhydrol","α,α-Diphenyl-2-piperidinemethanol","MRD-108","α,α-Diphenyl-α-(2-piperidyl)methanol","Dtxsid2023486","2-Piperidinemethanol, α,α-diphenyl-","Dtxcid903486","N06BX15","207-394-5","MRD 108","DEA No. 1750","Alertol","Einecs 207-394-5","Brn 0229537","Unii-s6i030e0da","HSDB 8016","Gerodil","Meratran","Leptidrol","Oprea1_717873","5-21-04-00070","Schembl156360","Schembl6867163","Chembl2110938","α-(2-Piperidyl)-benzohydrol","Chebi:135101","Diphenyl(2-piperidinyl)methanol #","STL508163","Akos015995614","DB11584","NS00017974","α-(2-Piperidyl)benzhydryl alcohol","α,α-Diphenyl-α-(2-piperidinyl)methanol"],"CAS":"467-60-7","ChemicalClasses":["2-benzylpiperidine"],"Chirality":"racemic","Classes":["Stimulant"],"Color/Form":"Crystals from hexane","Decomposition":"When heated to decomposition it emits toxic fumes of /nitrogen oxides/.","Drug Indication":"Used to manage fatigue and depression,,,. Used as an adjunct therapy in the management of obesity.","Drug Warnings":"Some patients may experience mild central stimulant side effects.","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"207-394-5","Formating":[],"HeavyAtomCount":20,"Human Drugs":"Pharmaceuticals","IUPACName":"diphenyl(piperidin-2-yl)methanol","InChI":"InChI=1S/C18H21NO/c20-18(15-9-3-1-4-10-15,16-11-5-2-6-12-16)17-13-7-8-14-19-17/h1-6,9-12,17,19-20H,7-8,13-14H2","InChIKey":"XSWHNYGMWWVAIE-UHFFFAOYSA-N","Interactions":"/LABORATORY ANIMALS: Acute Exposure/ Intravenous administration of the stimulant drug pipradrol evoked a dose-dependent hyperthermic response in rabbits. This drug effect was significantly reduced by pretreatment with chlorpromazine, phenoxybenzamine, intravenous BE-2254 or intracerebroventricular BE-2254. In animals pretreated with cyproheptadine or atropine, the hyperthermic effect was significantly potentiated. However, haloperidol, pimozide, diphenhydramine and pentobarbital failed to appreciably influence the drug response. These findings suggest that pipradrol-induced hyperthermia in the rabbit involves activation of central alpha-adrenergic receptors and is apparently enhanced by blockade of serotonergic or cholinergic receptors","MeSH Headers":[{"Id":"M0225300","Link":"https://id.nlm.nih.gov/mesh/M0225300.html","Name":"pipradrol","Ref":36},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":38},{"Id":"PubMed from MeSH","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":null,"Ref":51}],"Mechanism of Action":"Pipradrol and pipradrol derivatives are norepinephrine and dopamine reuptake inhibitors.    In a pharmacokinetic study, it was shown that pipradrol conditioned place preference (CPP) was blocked by selective D1 dopamine antagonist, implicating that a rewarding effect of pipradrol may involve the activation of D1 dopamine receptors.  Pipradrol has a definite cerebral stimulating effect without affecting the blood pressure or respiration and has been used to counteract post-anaesthetic and chlorpromazine depression in man. Structurally related to phenylmethylamphetamine, a potent stimulant with a long half-life, pipradrol differs from amphetamine in that its action is more intense at higher centers, it does not exhibit pressor activity, there is no post-excitement depression, and this drug does not decrease appetite, as occurs with amphetamine.","Melting Point":"97.5 °C","Metabolism/Metabolites":"Rapidly metabolized, and not found in plasma approximately 4 hours post administration.","MolecularFormula":"C\u003csub\u003e18\u003c/sub\u003eH\u003csub\u003e21\u003c/sub\u003eNO","MolecularWeight":"267.4 g/mol","Non-Human Toxicity Values":"LD50 Cat iv 15 mg/kg","Opticalactivity":"( + / - )","Pharmacodynamics":"Pipradrol (Meratran) is a psychoactive agent and a central nervous system stimulant that has proven useful in the field of psychiatry.  Pipradrol was initially used as an adjunct in the dietary management of obesity as well as for the management of dementia symptoms. Numerous reports have been made on the properties of pipradrol, demonstrating its favorable effects in the treatment of depression and fatigue in addition to a variety of other conditions including narcolepsy, spasmodic torticollis, schizophrenia and in geriatric practice.","PubChemId":10083,"Record Description":["Wikipedia|List of designer drugs|Stimulants|Tropanes and Piperidines"],"Records":{"UNII":{"Impurities":[]}},"RefChem":"174480","RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Pipradrol","Name":"Pipradrol","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q2084598","Name":"Pipradrol","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/DB11584","Name":"Pipradrol","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/10083","Name":"Pipradrol","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=467-60-7","Name":"Pipradrol","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/S6I030E0DA","Name":"Pipradrol","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID2023486","Name":"Pipradrol","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 10083, Pipradrol. Accessed May 8, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/10083\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/10083\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pipradrol. UNII: S6I030E0DA. Global Substance Registration System. Accessed May 8, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/S6I030E0DA\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/S6I030E0DA\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed May 8, 2026. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"SMILES":"C1CCNC(C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Australia","ref":[],"schedule":"S4 substance"},{"gov":"Brazil","ref":["3"],"schedule":"B1 substance"},{"gov":"Canada","ref":[],"schedule":"Schedule IV substance"},{"gov":"Germany","ref":[],"schedule":"Anlage III substance"},{"gov":"New Zealand","ref":[],"schedule":"Class C substance"},{"gov":"United Kingdom","ref":[],"schedule":"Class C substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"},{"gov":"United Nations","ref":[],"schedule":"Schedule IV substance"}],"StereoisomerData":[{"ChemicalClasses":["2-benzylpiperidine"],"SMILES":"OC(C1=CC=CC=C1)(C1=CC=CC=C1)[C@H]1CCCCN1","Structure":"\u003csvg 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class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":{"Cognitive Effects":["Analysis enhancement","Ego inflation","Focus enhancement","Increased music appreciation","Motivation enhancement","Thought acceleration","Wakefulness","Disinhibition","Suggestibility suppression","Cognitive euphoria","Compulsive redosing","Mania"],"Physical Effects":["Increased libido","Stamina enhancement","Stimulation","Appetite suppression","Dehydration","Dry mouth","Restless legs","Shakiness","Teeth grinding","Abnormal heartbeat","Increased blood pressure","Increased heart rate","Vasoconstriction"],"Visual Effects":[]},"Therapeutic Uses":"Alertonic /pipradol-vitamin preparation/ is indicated as a dietary supplement in nutritional fatigue when such fatigue is caused by a deficiency of those vitamins, minerals and trace elements supplied by Alertonic.","Title":"Pipradrol","UNII":"S6I030E0DA","Wikidata":"Q2084598","Wikipedia":"Pipradrol","XLogP":3}