{"Abbreviation":[],"Aliases":["1-Piperoylpiperidine","Piperin","Bioperine","Piperoylpiperidine","FEMA No. 2909","piperidine, 1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-","(2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one","N-[(E,E)-Piperoyl]piperidine","1-Piperoyl-piperidine","Piperidine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-, (E,E)-","Piperidine, 1-((2E,4E)-5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)-","Piperidine, 1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]-, (E,E)-","N-((E,E)-Piperoyl)piperidine","Piperine 1537","RefChem:6145","((1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine","(1-(5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl)piperidine","202-348-0","7780-20-3","(2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one","(E,E)-1-piperoylpiperidine","AI 3-01439","Piperidine, 1-piperoyl-, (E,E)-","1-[(2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoyl]piperidine","N-(E,E)-piperoyl-piperidine"],"Boiling Point":"498.00 to 499.00 °C. @ 760.00 mm Hg","CAS":"94-62-2","ChEBI":"CHEBI:28821","ChEMBL":"CHEMBL43185","ChemicalClasses":["alkylbenzene"],"Chirality":"achiral","EINECS":"202-348-0","Esters":[],"European Community (EC) Number":"202-348-0","Formating":[],"HMDB ID":"HMDB0029377","HeavyAtomCount":21,"IUPACName":"(2E,4E)-5-(1,3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one","InChI":"InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+","InChIKey":"MXXWOMGUGJBKIW-YPCIICBESA-N","LD50":[{"dosages":[{"amount":"105 mg/kg","route":"intraperitoneal"}],"organism":"Hamster"},{"dosages":[{"amount":"34 mg/kg","route":"intraperitoneal"},{"amount":"514 mg/kg","route":"oral"}],"organism":"Rat"},{"dosages":[{"amount":"330 mg/kg","route":"oral"},{"amount":"43 mg/kg","route":"intraperitoneal"},{"amount":"200 mg/kg","route":"subcutaneous"},{"amount":"15100 μg/kg","route":"intravenous"},{"amount":"400 μg/kg","route":"intramuscular"},{"amount":"71 mg/kg","route":"intravenous"}],"organism":"Mouse"}],"MeSH Pharmacological Classification":"Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 ENZYMES.","Melting Point":"129 °C","MolecularFormula":"C\u003csub\u003e17\u003c/sub\u003eH\u003csub\u003e19\u003c/sub\u003eNO\u003csub\u003e3\u003c/sub\u003e","MolecularWeight":"285.34 g/mol","Physical Description":"Light yellow to yellow solid with a pungent odor; [Reference #1] Light yellow solid; [Sigma-Aldrich MSDS]","PubChemId":638024,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Piperine","Name":"Piperine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q414501","Name":"Piperine","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB12582","Name":"Piperine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/638024","Name":"Piperine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL43185","Name":"Piperine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28821","Name":"Piperine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=94-62-2","Name":"Piperine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0029377","Name":"Piperine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C03882","Name":"Piperine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/U71XL721QK","Name":"Piperine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3021805","Name":"Piperine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 638024, Piperine. Accessed September 12, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/638024\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/638024\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Piperine. UNII: U71XL721QK. Global Substance Registration System. Accessed September 12, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/U71XL721QK\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/U71XL721QK\u003c/a\u003e"],"SMILES":"C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3","SaltData":[],"Salts":[],"Solubility":"0.04 mg/mL at 18 °C","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 157.529 49.848\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h158v50H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m156.486 41.181-13.203 7.629M143.283 48.81l-13.199-7.62M130.084 41.19l.004-11.399M133.242 24.119l10.05-5.806M143.292 18.313l13.199 7.62M156.486 41.181l.005-15.248M126.936 24.121l-10.045-5.8\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M115.672 19.025V7.002M118.11 19.025V7.002\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M115.672 7.002v6.011M118.11 7.002v6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m116.891 18.321-13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m103.693 25.941-13.199-7.62M103.693 23.126l-10.76-6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"m90.494 18.321-13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m77.296 25.941-13.198-7.62M77.296 23.126l-10.76-6.213\"/\u003e\u003c/g\u003e\u003cpath d=\"M64.098 18.321 50.9 25.941\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m50.9 25.941-13.203-7.628M48.462 27.349l-10.766-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"m37.697 18.313-13.199 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m24.498 25.933.005 15.248M26.937 27.34l.004 12.434\"/\u003e\u003c/g\u003e\u003cpath d=\"m24.503 41.181 13.203 7.629\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m37.706 48.81 13.199-7.62M37.707 45.994l10.759-6.212\"/\u003e\u003c/g\u003e\u003cpath d=\"m50.9 25.941.005 15.249M24.503 41.181 13.6 44.724M7.69 42.7l-6.641-9.136M1.049 33.564l6.635-9.139M24.498 25.933l-10.906-3.536\" class=\"bond\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M132.03 28.391h-.72l-2.62-4.066h-.03l.03.595q.024.357.024.732v2.739h-.566v-4.9h.715l2.607 4.055h.03l-.018-.328-.024-.476q-.006-.262-.006-.482v-2.769h.578z\" class=\"atom\"/\u003e\u003cpath stroke=\"none\" d=\"M119.15 3.078q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.392.53 1.22.53.839 0 1.22-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524-.392.523-.392 1.452M12.268 45.887q0 .757-.256 1.328-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.751.244-1.31.25-.566.756-.881t1.274-.316q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.863 0q0 .923.387 1.459.393.53 1.22.53.839 0 1.22-.53.387-.536.387-1.459 0-.928-.387-1.452-.381-.524-1.208-.524-.833 0-1.226.524t-.393 1.452M12.26 21.23q0 .756-.256 1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.732 0 1.232.315.5.31.756.875.256.566.256 1.328m-3.863 0q0 .922.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m130.088 29.791-.002 5.699M133.242 24.119l5.025-2.903M126.936 24.121l-5.023-2.9\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m13.6 44.724 5.452-1.771M7.69 42.7l-3.32-4.568M7.684 24.425l-3.317 4.57M13.592 22.397l5.453 1.768\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Piperine","UNII":"U71XL721QK","Wikidata":"Q414501","Wikipedia":"Piperine","XLogP":3.5}