{"Abbreviation":[],"Adverse Effects":"Neurotoxin - Other CNS neurotoxin","Aliases":["Hexahydropyridine","Cyclopentimine","Azacyclohexane","Piperidin","Cypentil","Hexazane","Pentamethyleneimine","Pentamethylenimine","Perhydropyridine","Pyridine, hexahydro-","FEMA No. 2908","RefChem:6144","203-813-0","Pentamethyleneamine","piperdine","Piperidine, homopolymer","PIP","azinane","89014-30-2","CCRIS 967","Piperidine, puriss. p.a., \u003e=99.0%","UN2401","piperadine","pyperidine","N-piperidine"],"Biological Half-Life":"When injected iv into rats, piperidine disappeared exponentially with a half-life of 20 min.","Boiling Point":"223 °","CAS":"110-89-4","ChEBI":"CHEBI:18049","ChEMBL":"CHEMBL15487","ChemicalClasses":["piperidine"],"Chirality":"achiral","Color/Form":"CLEAR, COLORLESS LIQUID","Decomposition":"... When heated to decomposition, it emits highly toxic fumes of oxides of /nitrogen oxides/. ... .","Density":"0.8622 at 68 °F (EPA, 1998) - Less dense than water; will float g/cm\u003csup\u003e3\u003c/sup\u003e","EINECS":"203-813-0","Ecotoxicity Values":"LC50 Daphnia magna /water flea/ 8.234 mg/L /48 hr. /Conditions of bioassay not specified/","Esters":[],"European Community (EC) Number":"203-813-0","Flash Point":"37.4 to 61 °F (EPA, 1998)","Formating":[],"HMDB ID":"HMDB0034301","HeavyAtomCount":6,"IUPACName":"piperidine","InChI":"InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2","InChIKey":"NQRYJNQNLNOLGT-UHFFFAOYSA-N","Interactions":"A study in ddy mice successfully demonstrated that simultaneous administration of nitrite and piperidine led to a marked increase in the incidence of urinary bladder cancer when cholesterol pellets containing piperidine hydrochloride were surgically implanted into the urinary bladder and the rats were given sodium nitrite (0.1%) in their drinking water for 40 weeks. /Piperidine hydrochloride/","LC50":[{"dosages":[{"amount":"6000 mg/m3/2H","route":"inhalation"}],"organism":"Mouse"},{"dosages":[{"amount":"6500 mg/m3","route":"inhalation"}],"organism":"Mammal (species unspecified)"}],"LD50":[{"dosages":[{"amount":"400 mg/kg","route":"oral"}],"organism":"Rat"},{"dosages":[{"amount":"30 mg/kg","route":"oral"},{"amount":"50 mg/kg","route":"intraperitoneal"}],"organism":"Mouse"},{"dosages":[{"amount":"145 mg/kg","route":"oral"},{"amount":"276 mg/kg","route":"skin"}],"organism":"Rabbit"},{"dosages":[{"amount":"22400 μg/kg","route":"oral"}],"organism":"Mammal (species unspecified)"}],"LDLo":[{"dosages":[{"amount":"300 mg/kg","route":"subcutaneous"},{"amount":"160 mg/kg","route":"intravenous"}],"organism":"Rabbit"}],"MeSH Pharmacological Classification":"A class of drugs that act by selective inhibition of calcium influx through cellular membranes.","Melting Point":"16 to 19 °F (EPA, 1998)","MolecularFormula":"C\u003csub\u003e5\u003c/sub\u003eH\u003csub\u003e11\u003c/sub\u003eN","MolecularWeight":"85.15 g/mol","Non-Human Toxicity Values":"LD50 Mouse oral (female) 536 mg/kg","Odor":"AMINE-LIKE ODOR","Physical Description":"Piperidine appears as a clear colorless liquid with a pepper-like odor. Less dense than water, but miscible in water. Will float on water. Flash point 37 °F. Melting point -15.8 °F (-9 °C). Boiling point 222.8 °F (106 °C). May severely irritate skin and eyes. May be toxic by ingestion and inhalation. Vapors heavier than air. Used to make rubber and as a solvent.","PubChemId":8082,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Piperidine","Name":"Piperidine","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q410234","Name":"Piperidine","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/8082","Name":"Piperidine","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL15487","Name":"Piperidine","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18049","Name":"Piperidine","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=110-89-4","Name":"Piperidine","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0034301","Name":"Piperidine","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C01746","Name":"Piperidine","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/67I85E138Y","Name":"Piperidine","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID6021165","Name":"Piperidine","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 8082, Piperidine. Accessed September 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/8082\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/8082\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Piperidine. UNII: 67I85E138Y. Global Substance Registration System. Accessed September 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/67I85E138Y\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/67I85E138Y\u003c/a\u003e"],"SMILES":"C1CCNCC1","SaltData":[{"AcidCount":1,"Amine":"Piperidine","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 51.386 39.972\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h52v40H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m14.239 1.038 13.2 7.616M27.439 8.654v15.231M27.439 23.885l-10.047 5.797M11.085 29.682 1.038 23.885M1.038 23.885V8.654M14.239 1.038 1.038 8.654\" 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1.327-.256.566-.756.881t-1.244.316q-.756 0-1.262-.316-.506-.315-.756-.887-.244-.571-.244-1.333 0-.75.244-1.31.25-.565.756-.881.506-.315 1.274-.315.732 0 1.232.315.5.31.756.875.256.566.256 1.328m-3.863 0q0 .923.387 1.458.393.53 1.22.53.84 0 1.221-.53.387-.535.387-1.458 0-.929-.387-1.453-.381-.524-1.209-.524-.833 0-1.226.524t-.393 1.453M50.74 9.237h-.619V6.951h-2.512v2.286h-.613V4.338h.613V6.41h2.512V4.338h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m51.261 25.713 3.571-2.062M51.261 25.713l3.571-2.062\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff8000\" d=\"m58.403 21.59-3.571 2.061M62.382 22.066l2.225 3.853\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m66.832 29.773-2.225-3.854\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff8000\" d=\"m59.067 16.324-1.77-3.065\" class=\"hi\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m55.528 10.194 1.769 3.065M55.528 10.194l1.769 3.065\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Piperidine 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