{"ATC Code":"N - Nervous system","Abbreviation":"","Aliases":["Phenoxazole","Phenylisohydantoin","Azoksodon","Fenoxazol","Azoxodon","Dantromin","Cylert","Pemolin","Tradon","Azoxodone","Centramin","Δmine","Hyton","Nitan","Kethamed","Sigmadyn","Stimulol","Okodon","Pioxol","Pondex","Sistra","Stimul","Tradone","Volital","Ronyl"],"Biological Half-Life":"The serum half-life of pemoline is approximately 12 hours.","CAS":"2152-34-3","ChEBI":"CHEBI:7953","ChEMBL":"CHEMBL1177","ChemicalClasses":["aminorex"],"Chirality":"racemic","Color/Form":"Crystals","Decomposition":"When heated to decomposition it emits toxic fumes of /Nitrogen oxide/.","Drug Indication":"For treatment of Attention Deficit Hyperactivity Disorder (ADHD)","Drug Warnings":"The Agency has concluded that the overall risk of liver toxicity from Cylert and generic pemoline products outweighs the benefits of this drug. In May 2005, Abbott chose to stop sales and marketing of Cylert in the U.S. All generic companies have also agreed to stop sales and marketing of this product (Pemoline tablets and chewable tablets).   Cylert is a central nervous system stimulant indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). This product is considered second line therapy for ADHD because of its association with life threatening hepatic failure.","EliminationHalfLife":"7 – 12 hours","Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"218-438-8","Formating":[],"HMDB ID":"HMDB0256214","HeavyAtomCount":13,"Human Drugs":"Human drug -\u003e Discontinued","IUPACName":"2-amino-5-phenyl-1,3-oxazol-4-one","InChI":"InChI=1S/C9H8N2O2/c10-9-11-8(12)7(13-9)6-4-2-1-3-5-6/h1-5,7H,(H2,10,11,12)","InChIKey":"NRNCYVBFPDDJNE-UHFFFAOYSA-N","MeSH Pharmacological Classification":"A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)","Melting Point":"Decomp: 256-257 °C","MolecularFormula":"C\u003csub\u003e9\u003c/sub\u003eH\u003csub\u003e8\u003c/sub\u003eN\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"176.17 g/mol","Opticalactivity":"( + / - )","Pharmacodynamics":"Pemoline belongs to the group of medicines called central nervous system (CNS) stimulants. It is used to treat attention deficit hyperactivity disorder (ADHD). Pemoline stimulates the brain, probably by affecting neurotransmitters, the chemicals in the brain that nerves use to communicate with each other.","PubChemId":4723,"Record Description":["LiverTox|CNS|ADHD|Oxazoline"],"RefCount":4,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Pemoline","Name":"Pemoline","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q419008","Name":"Pemoline","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01230","Name":"Pemoline","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/4723","Name":"Pemoline","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL1177","Name":"Pemoline","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:7953","Name":"Pemoline","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=2152-34-3","Name":"Pemoline","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0256214","Name":"Pemoline","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07899","Name":"Pemoline","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/7GAQ2332NK","Name":"Pemoline","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3023427","Name":"Pemoline","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 4723, Pemoline. Accessed July 13, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/4723\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/4723\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pemoline. UNII: 7GAQ2332NK. Global Substance Registration System. Accessed July 13, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/7GAQ2332NK\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/7GAQ2332NK\u003c/a\u003e","Anvisa. RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial. Diário Oficial da União. March 31, 2023. Accessed July 13, 2025. \u003ca href=https://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003ehttps://www.in.gov.br/en/web/dou/-/resolucao-rdc-n-784-de-31-de-marco-de-2023-474904992\u003c/a\u003e"],"SMILES":"C1=CC=C(C=C1)C2C(=O)N=C(O2)N","SaltData":[],"Salts":[],"Scheduling":[{"gov":"Australia","ref":[],"schedule":"S4 substance"},{"gov":"Brazil","ref":["3"],"schedule":"B1 substance"},{"gov":"Canada","ref":[],"schedule":"Schedule IV substance"},{"gov":"Germany","ref":[],"schedule":"prescription only/Anlage III substance"},{"act":"Controlled Substances Act (CSA)","gov":"United States","ref":[],"schedule":"Schedule I"}],"Solubility":"Practically insol in ether, acetone, dil hydrochloric acid; sol in propylene glycol (1%) and hot alcohol","StereoisomerData":[{"Aliases":null,"PubChemId":null,"SMILES":"NC1=NC(=O)[C@@H](c2ccccc2)O1","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 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