{"ATC Code":"C - Cardiovascular system","Abbreviation":"","Aliases":["N-Methyl-N-propargylbenzylamine","Pargylamine","Paragyline","Supirdyl","Eudatin","N-Methyl-N-2-propynylbenzylamine","Pargilina","Pargylinum","Benzenemethanamine, N-methyl-N-2-propynyl-","benzyl(methyl)(prop-2-yn-1-yl)amine","Hydrochloride, Pargyline","C02KC01","209-101-6","Pargylin","Benzyl-methyl-2-propinylamin","Benzylmethylpropargylamine","N-Benzyl-N-methyl-2-propynylamine","N-Methyl-N-benzylpropynylamine","Eutron","Methylbenzylpropynylamine","MO 911","N-Benzyl-N-methyl-2-propyn-1-amine","Pargyline chloride","Benzylamine, n-methyl-n-2-propynyl-","A 19120"],"CAS":"555-57-7","ChEBI":"CHEBI:7930","ChEMBL":"CHEMBL673","ChemicalClasses":["benzylamine"],"Chirality":"achiral","Classes":["Monoamine oxidase inhibitor"],"Drug Indication":"For the treatment of moderate to severe hypertension.","EINECS":"209-101-6","Erowid Experience Reports":null,"Esters":[],"European Community (EC) Number":"209-101-6","Formating":[],"HMDB ID":"HMDB0015563","HeavyAtomCount":12,"Human Drugs":"Human drug -\u003e Discontinued","IUPACName":"N-benzyl-N-methylprop-2-yn-1-amine","InChI":"InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3","InChIKey":"DPWPWRLQFGFJFI-UHFFFAOYSA-N","MeSH Pharmacological Classification":"Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)","MolecularFormula":"C\u003csub\u003e11\u003c/sub\u003eH\u003csub\u003e13\u003c/sub\u003eN","MolecularWeight":"159.23 g/mol","Pharmacodynamics":"Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as bleu cheese and beer, as this can lead to a hypertensive crisis.","Physical Description":"Solid","PubChemId":4688,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Pargyline","Name":"Pargyline","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB01626","Name":"Pargyline","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/4688","Name":"Pargyline","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL673","Name":"Pargyline","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:7930","Name":"Pargyline","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=555-57-7","Name":"Pargyline","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0015563","Name":"Pargyline","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C07414","Name":"Pargyline","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/9MV14S8G3E","Name":"Pargyline","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID3023423","Name":"Pargyline","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 4688, Pargyline. Accessed July 20, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/4688\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/4688\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Pargyline. UNII: 9MV14S8G3E. Global Substance Registration System. Accessed July 20, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/9MV14S8G3E\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/9MV14S8G3E\u003c/a\u003e"],"SMILES":"CN(CC#C)CC1=CC=CC=C1","SaltData":[{"AcidCount":1,"AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 118.596 32.573\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#1ff01f\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h119v33H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"M53.836 23.907v-11.39M56.989 6.846l10.045-5.799M67.034 1.047l13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m80.232 8.667 13.199 7.62M81.452 6.555l13.198 7.62M79.013 10.778l13.198 7.62\"/\u003e\u003c/g\u003e\u003cpath d=\"M50.683 6.846 40.638 1.047M40.638 1.047 27.44 8.667\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M27.44 8.667 14.236 1.038M25.002 10.074l-10.766-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"M14.236 1.038 1.038 8.658\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m1.038 8.658.005 15.249M3.477 10.066l.004 12.433\"/\u003e\u003c/g\u003e\u003cpath d=\"m1.043 23.907 13.203 7.628\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m14.246 31.535 13.198-7.62M14.247 28.719l10.759-6.211\"/\u003e\u003c/g\u003e\u003cpath d=\"m27.44 8.667.004 15.248\" class=\"bond\"/\u003e\u003cpath fill=\"#3050f8\" stroke=\"none\" d=\"M55.777 11.116h-.721L52.437 7.05h-.03l.03.596q.024.357.024.732v2.738h-.566V6.217h.715l2.607 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482V6.217h.578z\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"M53.836 12.517v5.695M56.989 6.846l5.022-2.9M50.683 6.846l-5.023-2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"mol\"\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M115.28 14.435q-.786 0-1.239.53-.452.524-.452 1.447 0 .911.417 1.446.422.53 1.268.53.321 0 .607-.053.292-.06.566-.143v.535q-.274.102-.566.149-.292.054-.697.054-.744 0-1.25-.31-.5-.309-.75-.875-.25-.571-.25-1.339 0-.744.268-1.31.274-.565.804-.881.53-.321 1.28-.321.78 0 1.351.285l-.244.524q-.226-.101-.506-.184-.274-.084-.607-.084m2.756 4.423h-.601v-5.215h.601zM112.373 18.858h-.62v-2.286h-2.512v2.286h-.613v-4.899h.613v2.072h2.512v-2.072h.62z\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"Pargyline hydrochloride","UNII":"W70V6I2OMY"}],"Salts":["hydrochloride"],"Solubility":"9.98e-02 g/L","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 95.688 32.573\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#3050f8\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h96v33H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"M53.836 23.907v-11.39M56.989 6.846l10.045-5.799M67.034 1.047l13.198 7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m80.232 8.667 13.199 7.62M81.452 6.555l13.198 7.62M79.013 10.778l13.198 7.62\"/\u003e\u003c/g\u003e\u003cpath d=\"M50.683 6.846 40.638 1.047M40.638 1.047 27.44 8.667\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M27.44 8.667 14.236 1.038M25.002 10.074l-10.766-6.22\"/\u003e\u003c/g\u003e\u003cpath d=\"M14.236 1.038 1.038 8.658\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m1.038 8.658.005 15.249M3.477 10.066l.004 12.433\"/\u003e\u003c/g\u003e\u003cpath d=\"m1.043 23.907 13.203 7.628\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"m14.246 31.535 13.198-7.62M14.247 28.719l10.759-6.211\"/\u003e\u003c/g\u003e\u003cpath d=\"m27.44 8.667.004 15.248\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M55.777 11.116h-.721L52.437 7.05h-.03l.03.596q.024.357.024.732v2.738h-.566V6.217h.715l2.607 4.054h.03l-.018-.327-.024-.477q-.006-.262-.006-.482V6.217h.578z\" class=\"atom\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"M53.836 12.517v5.695M56.989 6.846l5.022-2.9M50.683 6.846l-5.023-2.9\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"Pargyline","UNII":"9MV14S8G3E","Wikipedia":"Pargyline","XLogP":2.1}